KEGG   ORTHOLOGY: K19969
Entry
K19969                      KO                                     
Symbol
acbC, salQ, valA, cetA
Name
2-epi-5-epi-valiolone synthase [EC:4.2.3.152]
Pathway
map00525  Acarbose and validamycin biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00814  Acarbose biosynthesis, sedoheptulopyranose-7P => acarbose
M00815  Validamycin A biosynthesis, sedoheptulopyranose-7P => validamycin A
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00525 Acarbose and validamycin biosynthesis
    K19969  acbC, salQ, valA, cetA; 2-epi-5-epi-valiolone synthase
Enzymes [BR:ko01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.3  Acting on phosphates
    4.2.3.152  2-epi-5-epi-valiolone synthase
     K19969  acbC, salQ, valA, cetA; 2-epi-5-epi-valiolone synthase
Other DBs
RN: R10937
Genes
SERA: Ser39006_003950
SERQ: CWC46_03950
SLIG: GTU79_24420
RHD: R2APBS1_3641
RTH: LRK53_03190
PFC: PflA506_4591
PEZ: HWQ56_09190
PAEW: KIH87_05110
CJA: CJA_3250
GPB: HDN1F_13870(acbC)
BTZ: BTL_4163
BOK: DM82_5622
SUR: STAUR_1386(gacC)
CBB: CLD_3207
MMI: MMAR_0578(aroB_1)
MMAE: MMARE11_05350(aroB_1)
MHAD: B586_06435
MLJ: MLAC_02190(aroB_1)
NAD: NCTC11293_02222(aroB_1)
RER: RER_54360
REY: O5Y_25890
RHB: NY08_95
RHS: A3Q41_04747(aroB_3)
SRT: Srot_2448
SHY: SHJG_0276
SALS: SLNWT_0595
SGU: SGLAU_01035(gacC)
STRM: M444_32560
SRW: TUE45_05037(aroB_3)
SLE: sle_45870(sle_45870)
SFK: KY5_0702
SRJ: SRO_6646
SGF: HEP81_06989(gacC)
SCYG: S1361_01415(aroB2)
SAUH: SU9_022190
FAL: FRAAL4639
AOI: AORI_5447(aroB)
AORI: SD37_10235
SESP: BN6_52640
ACTI: UA75_21530
ACAD: UA74_21050
SAQ: Sare_2489
ASE: ACPL_3680(acbC) ACPL_6250
CWO: Cwoe_1465
AG: ABL74381(cetA)
 » show all
Reference
  Authors
Stratmann A, Mahmud T, Lee S, Distler J, Floss HG, Piepersberg W
  Title
The AcbC protein from Actinoplanes species is a C7-cyclitol synthase related to 3-dehydroquinate synthases and is involved in the biosynthesis of the alpha-glucosidase inhibitor acarbose.
  Journal
J Biol Chem 274:10889-96 (1999)
DOI:10.1074/jbc.274.16.10889
  Sequence
[ase:ACPL_3680]
Reference
  Authors
Choi WS, Wu X, Choeng YH, Mahmud T, Jeong BC, Lee SH, Chang YK, Kim CJ, Hong SK
  Title
Genetic organization of the putative salbostatin biosynthetic gene cluster including the 2-epi-5-epi-valiolone synthase gene in Streptomyces albus ATCC 21838.
  Journal
Appl Microbiol Biotechnol 80:637-45 (2008)
DOI:10.1007/s00253-008-1591-2
  Sequence
[sals:SLNWT_0595]
Reference
  Authors
Kean KM, Codding SJ, Asamizu S, Mahmud T, Karplus PA
  Title
Structure of a sedoheptulose 7-phosphate cyclase: ValA from Streptomyces hygroscopicus.
  Journal
Biochemistry 53:4250-60 (2014)
DOI:10.1021/bi5003508
  Sequence
[shy:SHJG_0276]
Reference
  Authors
Wu X, Flatt PM, Xu H, Mahmud T
  Title
Biosynthetic gene cluster of cetoniacytone A, an unusual aminocyclitol from the endosymbiotic Bacterium Actinomyces sp. Lu 9419.
  Journal
Chembiochem 10:304-14 (2009)
DOI:10.1002/cbic.200800527
  Sequence
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