KEGG   ORTHOLOGY: K20420
Entry
K20420                      KO                                     
Symbol
ncsB3
Name
2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31]
Pathway
map01059  Biosynthesis of enediyne antibiotics
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00830  Neocarzinostatin naphthoate moiety biosynthesis, malonyl-CoA => 2-hydroxy-5-methyl-1-naphthoate => 2-hydroxy-7-methoxy-5-methyl-1-naphthoyl-CoA
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01059 Biosynthesis of enediyne antibiotics
    K20420  ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K20420  ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.15  With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.15.31  2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase
     K20420  ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide tailoring proteins
  Oxygenase
   K20420  ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase
Other DBs
RN: R10796
COG: COG2124
Genes
LBQ: CKQ53_05320
ETP: LU633_02190
XOR: XOC_0085
XOZ: BE73_23900
XTN: FD63_13545
XTH: G4Q83_03485
MLO: mll6125
MERD: EB233_29925
NFA: NFA_22930 NFA_45180 NFA_53110
NFR: ERS450000_01804 ERS450000_04570 ERS450000_05413
SCO: SCO2884(SCE6.21) SCO7417(SC6D11.13c)
SMA: SAVERM_109(cyp1) SAVERM_1308(cyp6) SAVERM_3704(cyp17) SAVERM_3882(cyp19)
SBH: SBI_01881(cyp20) SBI_07324(cyp35) SBI_07588(cyp38)
SVE: SVEN_0422
SLE: sle_03480(sle_03480) sle_12110(sle_12110) sle_62170(sle_62170)
STRD: NI25_24330
SNF: JYK04_06995(ncsB3)
SHUN: DWB77_04303(ncsB3)
SCYG: S1361_02770(eryF1)
TCU: Tcur_1432
FAL: FRAAL1514
AMD: AMED_7339
AMN: RAM_37725
AMM: AMES_7228
AMZ: B737_7228
AOI: AORI_4218
AMI: Amir_3059
KAL: KALB_3732
ALO: CRK59466
SAQ: Sare_4949
AG: AAM77997(ncsB3)
 » show all
Reference
  Authors
Hang VT, Oh TJ, Yamaguchi T, Sohng JK
  Title
In vivo characterization of NcsB3 to establish the complete biosynthesis of the naphthoic acid moiety of the neocarzinostatin chromophore.
  Journal
FEMS Microbiol Lett 311:119-25 (2010)
DOI:10.1111/j.1574-6968.2010.02075.x
  Sequence
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