KEGG   ORTHOLOGY: K20422
Entry
K20422                      KO                                     

Symbol
ncsB
Name
neocarzinostatin naphthoate synthase [EC:2.3.1.237]
Pathway
map01059  Biosynthesis of enediyne antibiotics
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00830  Neocarzinostatin naphthoate moiety biosynthesis, malonyl-CoA => 2-hydroxy-5-methyl-1-naphthoate => 2-hydroxy-7-methoxy-5-methyl-1-naphthoyl-CoA
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01059 Biosynthesis of enediyne antibiotics
    K20422  ncsB; neocarzinostatin naphthoate synthase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K20422  ncsB; neocarzinostatin naphthoate synthase
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.237  neocarzinostatin naphthoate synthase
     K20422  ncsB; neocarzinostatin naphthoate synthase
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide synthase (PKS)
  Iterative type I PKS
   Bacterial type
    K20422  ncsB; neocarzinostatin naphthoate synthase
Other DBs
RN: R11125
COG: COG0331 COG0236 COG3321 COG1028
Genes
PSEP: C4K39_3072
SGZ: C0216_12005
SEN: SACE_5532
AORI: SD37_05100
SAQ: Sare_4951
MICH: FJK98_15495
ACTN: L083_3191(pks3C)
AG: AAM77986(ncsB)
Reference
  Authors
Hang VT, Oh TJ, Yamaguchi T, Sohng JK
  Title
In vivo characterization of NcsB3 to establish the complete biosynthesis of the naphthoic acid moiety of the neocarzinostatin chromophore.
  Journal
FEMS Microbiol Lett 311:119-25 (2010)
DOI:10.1111/j.1574-6968.2010.02075.x
  Sequence
LinkDB

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