KEGG   ORTHOLOGY: K20423
Entry
K20423                      KO                                     

Symbol
ncsB2
Name
2-hydroxy-7-methoxy-5-methyl-1-naphthoate---CoA ligase [EC:6.2.1.43]
Pathway
map01059  Biosynthesis of enediyne antibiotics
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00830  Neocarzinostatin naphthoate moiety biosynthesis, malonyl-CoA => 2-hydroxy-5-methyl-1-naphthoate => 2-hydroxy-7-methoxy-5-methyl-1-naphthoyl-CoA
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01059 Biosynthesis of enediyne antibiotics
    K20423  ncsB2; 2-hydroxy-7-methoxy-5-methyl-1-naphthoate---CoA ligase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K20423  ncsB2; 2-hydroxy-7-methoxy-5-methyl-1-naphthoate---CoA ligase
Enzymes [BR:ko01000]
 6. Ligases
  6.2  Forming carbon-sulfur bonds
   6.2.1  Acid-thiol ligases
    6.2.1.43  2-hydroxy-7-methoxy-5-methyl-1-naphthoate---CoA ligase
     K20423  ncsB2; 2-hydroxy-7-methoxy-5-methyl-1-naphthoate---CoA ligase
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide tailoring proteins
  Others
   K20423  ncsB2; 2-hydroxy-7-methoxy-5-methyl-1-naphthoate---CoA ligase
Other DBs
RN: R10771
COG: COG1021
Genes
MTS: MTES_3604
ARTP: E5206_14865
APN: Asphe3_39850
PSUL: AU252_00410
AOI: AORI_6598(dhbE)
AORI: SD37_05095
SAQ: Sare_4933
MICH: FJK98_15490
ACTN: L083_3190
AG: AAM77987(ncsB2)
Reference
  Authors
Cooke HA, Zhang J, Griffin MA, Nonaka K, Van Lanen SG, Shen B, Bruner SD
  Title
Characterization of NcsB2 as a promiscuous naphthoic acid/coenzyme A ligase integral to the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin.
  Journal
J Am Chem Soc 129:7728-9 (2007)
DOI:10.1021/ja071886a
  Sequence
LinkDB

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