KEGG   ORTHOLOGY: K20758Help
Entry
K20758            Tight     KO                                     

Name
hbzF
Definition
maleylpyruvate hydrolase [EC:3.7.1.23]
Pathway
ko00350  Tyrosine metabolism
ko01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00350 Tyrosine metabolism
    K20758  hbzF; maleylpyruvate hydrolase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.7  Acting on carbon-carbon bonds
   3.7.1  In ketonic substances
    3.7.1.23  maleylpyruvate hydrolase
     K20758  hbzF; maleylpyruvate hydrolase
BRITE hierarchy
Other DBs
RN: R11257
COG: COG0179
GO: 0102054
Genes
AG: ABD64512(hbzF)
TaxonomyKoalaUniProt
Reference
  Authors
Liu K, Liu TT, Zhou NY
  Title
HbzF catalyzes direct hydrolysis of maleylpyruvate in the gentisate pathway of Pseudomonas alcaligenes NCIMB 9867.
  Journal
Appl Environ Microbiol 79:1044-7 (2013)
DOI:10.1128/AEM.02931-12
  Sequence
LinkDB All DBs

KEGG   ENZYME: 3.7.1.23Help
Entry
EC 3.7.1.23                 Enzyme                                 

Name
maleylpyruvate hydrolase;
hbzF (gene name)
Class
Hydrolases;
Acting on carbon-carbon bonds;
In ketonic substances
BRITE hierarchy
Sysname
(2Z)-4,6-dioxohept-2-enedioate acylhydrolase
Reaction(IUBMB)
3-maleylpyruvate + H2O = maleate + pyruvate [RN:R11257]
Reaction(KEGG)
Substrate
3-maleylpyruvate [CPD:C02167];
H2O [CPD:C00001]
Product
maleate [CPD:C01384];
pyruvate [CPD:C00022]
Comment
The enzyme, characterized from the bacterium Pseudomonas alcaligenes NCIMB 9867, catalyses the hydrolysis of 3-maleylpyruvate, the ring-cleavage product of gentisate. The enzyme can also act on a number of maleylpyruvate derivatives, such as (2E)-2-methyl-4,6-dioxohept-2-enedioate and (2E)-3-methyl-4,6-dioxohept-2-enedioate. Activated by Mn2+. May be identical to EC 3.7.1.5, acylpyruvate hydrolase.
History
EC 3.7.1.23 created 2016
Pathway
ec00350  Tyrosine metabolism
ec01100  Metabolic pathways
Orthology
K20758  maleylpyruvate hydrolase
Reference
1  [PMID:5124802]
  Authors
Hopper DJ, Chapman PJ, Dagley S
  Title
The enzymic degradation of alkyl-substituted gentisates, maleates and malates.
  Journal
Biochem J 122:29-40 (1971)
Reference
2  [PMID:7400101]
  Authors
Bayly RC, Chapman PJ, Dagley S, Di Berardino D
  Title
Purification and some properties of maleylpyruvate hydrolase and fumarylpyruvate  hydrolase from Pseudomonas alcaligenes.
  Journal
J Bacteriol 143:70-7 (1980)
Reference
3  [PMID:23204427]
  Authors
Liu K, Liu TT, Zhou NY
  Title
HbzF catalyzes direct hydrolysis of maleylpyruvate in the gentisate pathway of Pseudomonas alcaligenes NCIMB 9867.
  Journal
Appl Environ Microbiol 79:1044-7 (2013)
DOI:10.1128/AEM.02931-12
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.7.1.23
IUBMB Enzyme Nomenclature: 3.7.1.23
ExPASy - ENZYME nomenclature database: 3.7.1.23
BRENDA, the Enzyme Database: 3.7.1.23
LinkDB All DBs

KEGG   REACTION: R11257Help
Entry
R11257                      Reaction                               

Name
(2Z)-4,6-dioxohept-2-enedioate acylhydrolase
Definition
Maleylpyruvate + H2O <=> Maleic acid + Pyruvate
Equation
Reaction class
RC00326  C00022_C02167
RC00446  C01384_C02167
Enzyme
Pathway
rn00350  Tyrosine metabolism
rn01100  Metabolic pathways
Orthology
K20758  maleylpyruvate hydrolase [EC:3.7.1.23]
Other DBs
RHEA: 47959
LinkDB All DBs

DBGET integrated database retrieval system