KEGG   ORTHOLOGY: K20838
Entry
K20838                      KO                                     

Name
NAT8
Definition
N-acetyltransferase 8 [EC:2.3.1.80 2.3.1.-]
Pathway
ko00480  Glutathione metabolism
ko01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00480 Glutathione metabolism
    K20838  NAT8; N-acetyltransferase 8
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.80  cysteine-S-conjugate N-acetyltransferase
     K20838  NAT8; N-acetyltransferase 8
    2.3.1.-  
     K20838  NAT8; N-acetyltransferase 8
Other DBs
RN: R04950
GO: 0047198
Genes
HSA: 51471(NAT8B) 9027(NAT8)
PTR: 470406(NAT8) 739241(NAT8B)
PPS: 100967484(NAT8) 100971190(NAT8B)
GGO: 101133830 109025735(NAT8)
PON: 100173062(NAT8) 100435458 100436198
NLE: 100606331 100606676
MCC: 706820(NAT8)
MCF: 102119614(NAT8)
CSAB: 103220050
RRO: 104661367(NAT8)
RBB: 108532437(NAT8)
CJC: 100394433(NAT8) 100407076
SBQ: 101032039(NAT8)
MMU: 100043497(Nat8f7) 100504710(Nat8f6) 66116(Nat8f1) 68396(Nat8) 69049(Nat8f5) 93673(Nat8f2) 93674(Nat8f3)
RNO: 102549803(Nat8f4) 102556148 103690120 113892(Nat8f3) 114020(Nat8f5) 500237(Cml2) 59300(Nat8f1) 64570(Nat8)
NGI: 103749950(Nat8b)
HGL: 101720890
TUP: 102482811(NAT8)
CFA: 100856478(NAT8)
VVP: 112916821(NAT8)
AML: 100481005(NAT8)
UMR: 103671389
UAH: 113243903(NAT8)
ORO: 101363205(NAT8B)
ELK: 111148203
FCA: 101098621(NAT8)
PTG: 102957307(NAT8B)
PPAD: 109262891(NAT8)
AJU: 106967787(NAT8)
BTA: 101902604(NAT8)
BOM: 102278525(NAT8)
BIU: 109565932(NAT8)
BBUB: 102392037(NAT8)
CHX: 102181787(NAT8)
OAS: 101104899(NAT8)
SSC: 100516363(NAT8)
CFR: 102507921(NAT8) 116669040
BACU: 103001786(NAT8) 103011589(NAT8B)
OOR: 101283003(NAT8B)
DLE: 111167883(NAT8)
PCAD: 112067510(NAT8)
EPZ: 103542782
MYB: 102238886(NAT8B) 102258540 102264232(NAT8)
DRO: 112303117(NAT8)
RAY: 107502947
MJV: 108389752
TMU: 101353867
GGA: 107056278 429762(NAT8) 776932(NAT8B)
MGP: 104916712
TGU: 115494848(NAT8)
LSR: 110469863(NAT8)
PHI: 102103115
PMAJ: 107199384(NAT8)
ETL: 114070483
CLV: 110365702
AAM: 106485319
PMUA: 114604315 114604606(NAT8)
XTR: 100124951(nat8.1) 100145252(nat8.7) 100489204(nat8.2) 100489358(nat8.3) 100489520(nat8.5) 100489681 100489847(nat8.9) 101731538(nat8.6) 493291(nat8.4)
DRE: 100002956(si:ch211-195e19.1) 100004652(nat8l2)
IPU: 100528621(cmlo) 108271756
RTP: 109919252
OBI: 106868182
EPA: 110234338
ADF: 107355193
 » show all
Reference
  Authors
Veiga-da-Cunha M, Tyteca D, Stroobant V, Courtoy PJ, Opperdoes FR, Van Schaftingen E
  Title
Molecular identification of NAT8 as the enzyme that acetylates cysteine S-conjugates to mercapturic acids.
  Journal
J Biol Chem 285:18888-98 (2010)
DOI:10.1074/jbc.M110.110924
  Sequence
[hsa:9027]
LinkDB

KEGG   ENZYME: 2.3.1.80
Entry
EC 2.3.1.80                 Enzyme                                 

Name
cysteine-S-conjugate N-acetyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
acetyl-CoA:S-substituted L-cysteine N-acetyltransferase
Reaction(IUBMB)
acetyl-CoA + an L-cysteine-S-conjugate = CoA + an N-acetyl-L-cysteine-S-conjugate [RN:R04950]
Reaction(KEGG)
R04950
Substrate
acetyl-CoA [CPD:C00024];
L-cysteine-S-conjugate [CPD:C02882]
Product
CoA [CPD:C00010];
N-acetyl-L-cysteine-S-conjugate
Comment
S-Benzyl-L-cysteine and, in decreasing order of activity, S-butyl-L-cysteine, S-propyl-L-cysteine, O-benzyl-L-serine and S-ethyl-L-cysteine, can act as acceptors.
History
EC 2.3.1.80 created 1984
Pathway
ec00480  Glutathione metabolism
ec01100  Metabolic pathways
Orthology
K20838  N-acetyltransferase 8
Genes
HSA: 51471(NAT8B) 9027(NAT8)
PTR: 470406(NAT8) 739241(NAT8B)
PPS: 100967484(NAT8) 100971190(NAT8B)
GGO: 101133830 109025735(NAT8)
PON: 100173062(NAT8) 100435458 100436198
NLE: 100606331 100606676
MCC: 706820(NAT8)
MCF: 102119614(NAT8)
CSAB: 103220050
RRO: 104661367(NAT8)
RBB: 108532437(NAT8)
CJC: 100394433(NAT8) 100407076
SBQ: 101032039(NAT8)
MMU: 100043497(Nat8f7) 100504710(Nat8f6) 66116(Nat8f1) 68396(Nat8) 69049(Nat8f5) 93673(Nat8f2) 93674(Nat8f3)
RNO: 102549803(Nat8f4) 102556148 103690120 113892(Nat8f3) 114020(Nat8f5) 500237(Cml2) 59300(Nat8f1) 64570(Nat8)
NGI: 103749950(Nat8b)
HGL: 101720890
TUP: 102482811(NAT8)
CFA: 100856478(NAT8)
VVP: 112916821(NAT8)
AML: 100481005(NAT8)
UMR: 103671389
UAH: 113243903(NAT8)
ORO: 101363205(NAT8B)
ELK: 111148203
FCA: 101098621(NAT8)
PTG: 102957307(NAT8B)
PPAD: 109262891(NAT8)
AJU: 106967787(NAT8)
BTA: 101902604(NAT8)
BOM: 102278525(NAT8)
BIU: 109565932(NAT8)
BBUB: 102392037(NAT8)
CHX: 102181787(NAT8)
OAS: 101104899(NAT8)
SSC: 100516363(NAT8)
CFR: 102507921(NAT8) 116669040
BACU: 103001786(NAT8) 103011589(NAT8B)
OOR: 101283003(NAT8B)
DLE: 111167883(NAT8)
PCAD: 112067510(NAT8)
EPZ: 103542782
MYB: 102238886(NAT8B) 102258540 102264232(NAT8)
DRO: 112303117(NAT8)
RAY: 107502947
MJV: 108389752
TMU: 101353867
GGA: 107056278 429762(NAT8) 776932(NAT8B)
MGP: 104916712
TGU: 115494848(NAT8)
LSR: 110469863(NAT8)
PHI: 102103115
PMAJ: 107199384(NAT8)
ETL: 114070483
CLV: 110365702
AAM: 106485319
PMUA: 114604315 114604606(NAT8)
XTR: 100124951(nat8.1) 100145252(nat8.7) 100489204(nat8.2) 100489358(nat8.3) 100489520(nat8.5) 100489681 100489847(nat8.9) 101731538(nat8.6) 493291(nat8.4)
DRE: 100002956(si:ch211-195e19.1) 100004652(nat8l2)
IPU: 100528621(cmlo) 108271756
RTP: 109919252
OBI: 106868182
EPA: 110234338
ADF: 107355193
 » show all
Reference
1  [PMID:6892478]
  Authors
Duffel MW, Jakoby WB.
  Title
Cysteine S-conjugate N-acetyltransferase from rat kidney microsomes.
  Journal
Mol Pharmacol 21:444-8 (1982)
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.80
IUBMB Enzyme Nomenclature: 2.3.1.80
ExPASy - ENZYME nomenclature database: 2.3.1.80
BRENDA, the Enzyme Database: 2.3.1.80
CAS: 81725-80-6
LinkDB

KEGG   REACTION: R04950
Entry
R04950                      Reaction                               

Name
Acetyl-CoA:S-substituted L-cysteine N-acetyltransferase
Definition
Acetyl-CoA + S-Substituted L-cysteine <=> CoA + S-Substituted N-acetyl-L-cysteine
Equation
Reaction class
RC00004  C00010_C00024
RC00064  C05726_C05727
Enzyme
Pathway
rn00480  Glutathione metabolism
rn01100  Metabolic pathways
Orthology
K20838  N-acetyltransferase 8 [EC:2.3.1.80 2.3.1.-]
Other DBs
RHEA: 19216
LinkDB

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