KEGG   ORTHOLOGY: K20858
Entry
K20858                      KO                                     

Name
MCU
Definition
calcium uniporter protein, mitochondrial
Pathway
ko04020  Calcium signaling pathway
ko04218  Cellular senescence
ko04621  NOD-like receptor signaling pathway
ko05010  Alzheimer disease
ko05012  Parkinson disease
ko05014  Amyotrophic lateral sclerosis
ko05017  Spinocerebellar ataxia
ko05020  Prion disease
ko05022  Pathways of neurodegeneration - multiple diseases
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    K20858  MCU; calcium uniporter protein, mitochondrial
 09140 Cellular Processes
  09143 Cell growth and death
   04218 Cellular senescence
    K20858  MCU; calcium uniporter protein, mitochondrial
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    K20858  MCU; calcium uniporter protein, mitochondrial
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K20858  MCU; calcium uniporter protein, mitochondrial
   05012 Parkinson disease
    K20858  MCU; calcium uniporter protein, mitochondrial
   05014 Amyotrophic lateral sclerosis
    K20858  MCU; calcium uniporter protein, mitochondrial
   05017 Spinocerebellar ataxia
    K20858  MCU; calcium uniporter protein, mitochondrial
   05020 Prion disease
    K20858  MCU; calcium uniporter protein, mitochondrial
   05022 Pathways of neurodegeneration - multiple diseases
    K20858  MCU; calcium uniporter protein, mitochondrial
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03029 Mitochondrial biogenesis
    K20858  MCU; calcium uniporter protein, mitochondrial
  09183 Protein families: signaling and cellular processes
   02000 Transporters
    K20858  MCU; calcium uniporter protein, mitochondrial
Mitochondrial biogenesis [BR:ko03029]
 Mitochondrial protein import machinery
  Inner mambrane
   Mitochondrial calcium uniporter complex
    K20858  MCU; calcium uniporter protein, mitochondrial
Transporters [BR:ko02000]
 Other transporters
  Pores ion channels
   K20858  MCU; calcium uniporter protein, mitochondrial
Other DBs
GO: 0005262 0015292
TC: 1.A.77.1
Genes
HSA: 90550(MCU)
PTR: 466291(MCU)
PPS: 100990265(MCU)
GGO: 109028462(MCU)
PON: 100441587(MCU)
NLE: 100600612(MCU)
MCC: 708334(MCU)
MCF: 102134282(MCU)
CSAB: 103216021(MCU)
RRO: 104669950(MCU)
RBB: 108516879(MCU)
CJC: 100395618(MCU)
SBQ: 101031167(MCU)
MMU: 215999(Mcu)
MCAL: 110302688(Mcu)
MPAH: 110326646(Mcu)
RNO: 294560(Mcu)
MUN: 110557989(Mcu)
CGE: 100762628(Mcu)
NGI: 103736958(Mcu)
HGL: 101700272(Mcu)
CCAN: 109688244
OCU: 100341372(MCU)
TUP: 102468332(MCU)
CFA: 489042(MCU)
VVP: 112924193(MCU)
AML: 100475721(MCU)
UMR: 103668021(MCU)
UAH: 113259163(MCU)
ORO: 101376167(MCU)
ELK: 111145292
FCA: 101083455(MCU)
PTG: 102969716(MCU)
PPAD: 109264395(MCU)
AJU: 106970956(MCU)
BTA: 536656(MCU)
BOM: 102264532(MCU)
BIU: 109553778(MCU)
BBUB: 102412937(MCU)
CHX: 102184878(MCU)
OAS: 101115342(MCU)
SSC: 100153794(MCU)
CFR: 102507581(MCU)
CDK: 105092475(MCU)
BACU: 103007311(MCU)
LVE: 103070730(MCU)
OOR: 101270140(MCU)
DLE: 111183499(MCU)
PCAD: 102979639(MCU)
ECB: 100072824(MCU)
EPZ: 103557867(MCU)
EAI: 106842371
MYB: 102238865(MCU)
MYD: 102769306(MCU)
MNA: 107545816(MCU)
HAI: 109372784(MCU)
DRO: 112305450(MCU)
PALE: 102896287(MCU)
RAY: 107516793
MJV: 108394930(MCU)
LAV: 100662469(MCU)
MDO: 100010373(MCU)
SHR: 100913360(MCU)
PCW: 110221459(MCU)
OAA: 100077394(MCU)
GGA: 428942(MCU)
MGP: 100546508(MCU)
CJO: 107315700(MCU)
NMEL: 110400250(MCU)
APLA: 101790944(MCU)
ACYG: 106030609(MCU)
TGU: 100219709(MCU)
LSR: 110477781(MCU)
SCAN: 103823735(MCU)
GFR: 102041999(MCU)
FAB: 101811915(MCU)
PHI: 102100271(MCU)
PMAJ: 107206684(MCU)
CCAE: 111931455(MCU)
CCW: 104695053(MCU)
ETL: 114067920(MCU)
FPG: 101924046(MCU)
FCH: 102054547(MCU)
CLV: 102085392(MCU)
EGZ: 104128410(MCU)
NNI: 104013561(MCU)
ACUN: 113481825(MCU)
PADL: 103918591(MCU)
AAM: 106498571(MCU)
ASN: 102378241(MCU)
AMJ: 102559262(MCU)
PSS: 102451453(MCU)
CMY: 102933882(MCU)
CPIC: 101947133(MCU)
ACS: 100564844(mcu)
PVT: 110073696(MCU)
PBI: 103059552(MCU)
PMUR: 107295795(MCU)
TSR: 106555359(MCU)
PMUA: 114597256(MCU)
GJA: 107109536(MCU)
XLA: 100037005(mcu.L) 108697483
XTR: 100170451(mcu)
NPR: 108799532(MCU)
DRE: 768182(mcu)
IPU: 108263040(mcu)
PHYP: 113542075(mcu)
AMEX: 103027768(mcu)
EEE: 113585469(mcu)
TRU: 101062308(mcu)
LCO: 104918533(mcu)
NCC: 104952219(mcu)
MZE: 101477384(mcu)
ONL: 100711994(mcu)
OLA: 101162626(mcu)
XMA: 102220558(mcu)
XCO: 114137485(mcu)
PRET: 103477070(mcu)
NFU: 107375762(mcu)
KMR: 108234010(mcu)
ALIM: 106515933(mcu)
AOCE: 111576101(mcu)
CSEM: 103387579(mcu)
POV: 109630659(mcu)
LCF: 108872429(mcu)
SDU: 111220662(mcu)
SLAL: 111658957(mcu)
HCQ: 109516140(mcu)
BPEC: 110156991(mcu)
MALB: 109961779(mcu)
SASA: 106593691(mcu)
OTW: 112243879
SALP: 112078416
ELS: 105008769(mcu)
SFM: 108925848(mcu)
PKI: 111849606(mcu)
LCM: 102366118(MCU)
CMK: 103181278(mcu)
RTP: 109936848(mcu)
BFO: 118412371
CIN: 100175007
APLC: 110991117
SKO: 100374182
DME: Dmel_CG18769(MCU)
DER: 6545445
DSE: 6611031
DSI: Dsimw501_GD13962(Dsim_GD13962)
DAN: 6506183
DSR: 110178786
DPE: 6601689
DMN: 108151697
DWI: 6645051
DAZ: 108614223
DNV: 108651965
DHE: 111600528
DVI: 6623674
MDE: 101892637
LCQ: 111681413
AAG: 5578225
AME: 725974
BIM: 105682138
BTER: 100643658
CCAL: 108622935
OBB: 114874911
SOC: 105196804
MPHA: 105827823
AEC: 105152219
ACEP: 105620999
PBAR: 105427664
VEM: 105559173
HST: 105183785
DQU: 106744444
CFO: 105247915
LHU: 105676488
PGC: 109852722
OBO: 105277742
PCF: 106789464
NVI: 100120233
CSOL: 105364186
MDL: 103573175
TCA: 660595
DPA: 109533996
NVL: 108560220
BMOR: 101746817
BMAN: 114246745
PMAC: 106709064
PRAP: 110997730
HAW: 110375028
TNL: 113502318
API: 100166457
DNX: 107168861
AGS: 114124026
RMD: 113560733
BTAB: 109043393
CLEC: 106671048
ZNE: 110838465
FCD: 110845327
PVM: 113823797
TUT: 107370237
CSCU: 111634984
PTEP: 107439563
CEL: CELE_K02B2.3(mcu-1)
CBR: CBG09462
TSP: Tsp_12846
PCAN: 112560239
CRG: 105328733
MYI: 110464245
OBI: 106867904
SHX: MS3_04792
EGL: EGR_04585
NVE: 5502959
EPA: 110231766
ADF: 107354168
AMIL: 114960426
PDAM: 113666059
SPIS: 111336799
DGT: 114523144
HMG: 100206887
AQU: 100641043
LJA: Lj0g3v0362789.1(Lj0g3v0362789.1) Lj0g3v0362789.2(Lj0g3v0362789.2) Lj2g3v1643250.1(Lj2g3v1643250.1) Lj5g3v0085200.1(Lj5g3v0085200.1)
DOSA: Os01t0817000-01(Os01g0817000) Os03t0233000-01(Os03g0233000) Os10t0501500-01(Os10g0501500) Os11t0124500-01(Os11g0124500) Os12t0122100-01(Os12g0122100)
ATS: 109733258(LOC109733258) 109755512(LOC109755512) 109767961(LOC109767961) 109772028(LOC109772028) 109773675(LOC109773675) 109781190(LOC109781190)
APRO: F751_5306
NCR: NCU08166
NTE: NEUTE1DRAFT131485(NEUTE1DRAFT_131485)
MGR: MGG_13655
SSCK: SPSK_03298
MAW: MAC_01752
MAJ: MAA_05443
CMT: CCM_08584
ELA: UCREL1_56
MBE: MBM_04112
ANG: ANI_1_1986184(An04g06590)
PTE: PTT_00799
CNE: CNA00980
CNB: CNBA0950
DFA: DFA_04059
SPAR: SPRG_08845
 » show all
Reference
  Authors
Baughman JM, Perocchi F, Girgis HS, Plovanich M, Belcher-Timme CA, Sancak Y, Bao XR, Strittmatter L, Goldberger O, Bogorad RL, Koteliansky V, Mootha VK
  Title
Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter.
  Journal
Nature 476:341-5 (2011)
DOI:10.1038/nature10234
  Sequence
[mmu:215999]
Reference
  Authors
De Stefani D, Raffaello A, Teardo E, Szabo I, Rizzuto R
  Title
A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter.
  Journal
Nature 476:336-40 (2011)
DOI:10.1038/nature10230
  Sequence
[hsa:90550]
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