KEGG ORTHOLOGY: K21052

ORTHOLOGY: K21052

Entry

K21052                      KO

Symbol

TMEM5

Name

alpha-dystroglycan beta1,4-xylosyltransferase [EC:2.4.2.61]

Pathway

map00515

Mannose type O-glycan biosynthesis

map01100

Metabolic pathways

Module

M00872

O-glycan biosynthesis, mannose type (core M3)

Disease

H00120

Muscular dystrophy-dystroglycanopathy type A

H02307

Muscular dystrophy-dystroglycanopathy

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09107 Glycan biosynthesis and metabolism
   00515 Mannose type O-glycan biosynthesis
    K21052  TMEM5; alpha-dystroglycan beta1,4-xylosyltransferase
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01003 Glycosyltransferases
    K21052  TMEM5; alpha-dystroglycan beta1,4-xylosyltransferase
Enzymes [BR:ko01000]
2. Transferases
  2.4  Glycosyltransferases
   2.4.2  Pentosyltransferases
    2.4.2.61  alpha-dystroglycan beta1,4-xylosyltransferase
     K21052  TMEM5; alpha-dystroglycan beta1,4-xylosyltransferase
Glycosyltransferases [BR:ko01003]
Glycan extension
  O-Glycan
   K21052  TMEM5; alpha-dystroglycan beta1,4-xylosyltransferase

Other DBs

RN:

R12244

Genes

HSA:	10329(RXYLT1)

PTR:	452041(RXYLT1)

PPS:	100992813(RXYLT1)

GGO:	101133488(RXYLT1)

PON:	100460186(RXYLT1)

NLE:	100584744(RXYLT1)

MCC:	717102(RXYLT1)

MCF:	102139236(RXYLT1)

CSAB:

103238633(TMEM5)

CATY:

105600545(TMEM5)

PANU:

101025195(RXYLT1)

TGE:	112634609(RXYLT1)

RRO:	104680841(RXYLT1)

RBB:	108530040(TMEM5)

TFN:	117089823(RXYLT1)

PTEH:

111551238(RXYLT1)

CJC:	100396930(TMEM5)

SBQ:	101051694(TMEM5)

CSYR:

103266851(TMEM5)

MMUR:

105880958(TMEM5)

OGA:	100966708(RXYLT1)

MMU:	216395(Rxylt1)

MCAL:

110303339(Tmem5)

MPAH:

110326592(Tmem5)

RNO:	299841(Rxylt1)

MCOC:

116076336(Rxylt1)

MUN:

110544358

CGE:	100757873(Rxylt1)

PLEU:

114693289(Rxylt1)

NGI:

103732350

HGL:	101716790(Tmem5) 106007506

CPOC:

100732505(Rxylt1)

CCAN:

109688718(Tmem5)

DORD:

105990711(Tmem5)

DSP:	122124346(Rxylt1)

OCU:	100345411(TMEM5)

OPI:	101534296(RXYLT1)

TUP:	102496430(TMEM5)

CFA:	608152(RXYLT1)

VVP:	112922312(RXYLT1)

VLG:	121492180(RXYLT1)

AML:	100464740(RXYLT1)

UMR:	103656829(TMEM5)

UAH:	113256338(RXYLT1)

UAR:	123787181(RXYLT1)

ELK:

111159758

LLV:

125107638

MPUF:

101692107(TMEM5)

ORO:	101385557(TMEM5)

EJU:	114214982(RXYLT1)

ZCA:	113923143(RXYLT1)

MLX:	118008632(RXYLT1)

FCA:	101101235(TMEM5)

PYU:	121040832(RXYLT1)

PBG:	122473937(RXYLT1)

PTG:	102958532(TMEM5)

PPAD:

109270421(TMEM5)

AJU:	106981335(RXYLT1)

HHV:	120233157(RXYLT1)

BTA:	515147(RXYLT1)

BOM:	102280602(TMEM5)

BIU:	109559282(TMEM5)

BBUB:

102406645(RXYLT1)

CHX:	102188924(TMEM5)

OAS:	101112124(RXYLT1)

ODA:	120858488(RXYLT1)

CCAD:

122427575(RXYLT1)

SSC:	100155789(TMEM5)

CFR:	102515986(RXYLT1)

CBAI:

105081364(TMEM5)

CDK:	105089266(RXYLT1)

VPC:	102529141(RXYLT1)

BACU:

103019229(TMEM5)

LVE:	103083549(TMEM5)

OOR:	101289176(TMEM5)

DLE:	111173799(RXYLT1)

PCAD:

102973659(RXYLT1)

PSIU:

116761140 116761329(RXYLT1)

ECB:	100056566(RXYLT1)

EPZ:	103553856(TMEM5)

EAI:	106843751(RXYLT1)

MYB:	102249341(TMEM5)

MYD:	102767891(TMEM5)

MMYO:

118651451(RXYLT1)

MLF:	102427668(RXYLT1) 102441512

MNA:	107527142(TMEM5)

PKL:	118729942(RXYLT1)

HAI:	109381648(TMEM5)

DRO:	112319159(RXYLT1)

SHON:

118998717(RXYLT1)

AJM:	119045542(RXYLT1)

PDIC:

114514076(RXYLT1)

PHAS:

123812739(RXYLT1)

MMF:	118624068(RXYLT1)

RFQ:	117029102(RXYLT1)

PALE:

102877783(RXYLT1)

PGIG:

120605002(RXYLT1)

PVP:	105301072(RXYLT1)

RAY:	107508215(TMEM5)

MJV:	108403882 108405319(TMEM5)

TOD:	119248114(RXYLT1)

SARA:

101537526(TMEM5)

LAV:	100665764(RXYLT1)

TMU:

101347097

DNM:	101424956(RXYLT1)

GAS:	123248666(RXYLT1)

SHR:	100933243(RXYLT1)

PCW:	110203945 110204694 110211014(TMEM5)

OAA:	100086919(RXYLT1)

GGA:	417820(RXYLT1)

PCOC:

116226623(RXYLT1)

MGP:	100544427(RXYLT1)

CJO:	107310084(RXYLT1)

NMEL:

110392741(TMEM5)

APLA:

101796104(RXYLT1)

ACYG:

106047283(TMEM5)

AFUL:

116501929(RXYLT1)

TGU:	100218010(RXYLT1)

LSR:	110479854(RXYLT1)

SCAN:

103820429(RXYLT1)

PMOA:

120499876(RXYLT1)

OTC:	121339510(RXYLT1)

PRUF:

121352594(RXYLT1)

GFR:	102039233(TMEM5)

FAB:	101807811(TMEM5)

PHI:	102110954(TMEM5)

PMAJ:

107205102(TMEM5)

CCAE:

111932408(RXYLT1)

CCW:	104698351(RXYLT1)

ETL:	114059396(RXYLT1)

ZAB:	102074450(RXYLT1)

FPG:	101921640(TMEM5)

FCH:	102053891(RXYLT1)

CLV:	102086203(TMEM5)

EGZ:	104135953(TMEM5)

NNI:	104011529(TMEM5)

ACUN:

113491375(RXYLT1)

TALA:

104361336(RXYLT1)

PADL:

103919977(TMEM5)

ACHC:

115336229(RXYLT1)

AAM:	106488143(TMEM5)

AROW:

112977820(RXYLT1)

NPD:	112947669(RXYLT1)

DNE:	112978733(RXYLT1)

ASN:	102382915(RXYLT1)

AMJ:	102576823(TMEM5)

CPOO:

109315551(TMEM5)

GGN:	109295685(TMEM5)

PSS:	102459090(RXYLT1)

CMY:	102939667(RXYLT1)

CPIC:

101945589(RXYLT1)

TST:	117877384(RXYLT1)

CABI:

116818548(RXYLT1)

MRV:	120384091(RXYLT1)

ACS:	100560359 103278900(tmem5)

PVT:	110075094(TMEM5)

SUND:

121931898(RXYLT1)

PBI:	103064453(RXYLT1)

PMUR:

107293325(RXYLT1)

TSR:	106543805(TMEM5)

PGUT:

117655858(RXYLT1)

VKO:	123019915(RXYLT1)

PMUA:

114605526(RXYLT1)

ZVI:	118091498(RXYLT1)

GJA:	107123401(TMEM5)

XLA:	446820(rxylt1.S)

XTR:	100145540(rxylt1)

NPR:	108792582(TMEM5)

RTEM:

120932022(RXYLT1)

BBUF:

120980170(RXYLT1)

BGAR:

122925898(RXYLT1)

DRE:	557187(rxylt1)

SRX:	107722461 107738400

SANH:

107670366(tmem5) 107684684

SGH:	107559810 107587049

CCAR:

109110172(tmem5)

CAUA:

113061550 113118230

IPU:	108264772(rxylt1) 124627936

PHYP:

113534283(rxylt1)

SMEO:

124396125(rxylt1)

AMEX:

103039815(tmem5)

EEE:	113577197(rxylt1)

TRU:	101064249(rxylt1)

TNG:	GSTEN00015931G001

LCO:	104923719(rxylt1)

NCC:	104949270(tmem5)

CGOB:

115009478(rxylt1)

ELY:	117253306(rxylt1)

PLEP:

121950421(rxylt1)

SLUC:

116038615(rxylt1)

ECRA:

117948638(rxylt1)

PFLV:

114559947(rxylt1)

GAT:	120808735 120812786

PPUG:

119195733(rxylt1)

MSAM:

119894254(rxylt1)

CUD:	121514766(rxylt1)

MZE:	101485151(rxylt1)

ONL:	100696362(rxylt1)

OAU:	116312560(rxylt1)

OLA:	101158942(rxylt1)

OML:	112152355(rxylt1)

XMA:	102232454(rxylt1)

XCO:	114155264(rxylt1)

XHE:	116734586(rxylt1)

PRET:

103466210(tmem5)

PFOR:

103144377(tmem5)

PLAI:

106956353(tmem5)

PMEI:

106918862(tmem5)

GAF:	122836255(rxylt1)

CVG:	107082444(tmem5)

CTUL:

119796790(rxylt1)

GMU:	124855859(rxylt1)

NFU:	107389076(tmem5)

KMR:	108237463(rxylt1)

ALIM:

106523189 106534997(tmem5)

NWH:	119415608(rxylt1)

AOCE:

111575928(tmem5)

CSEM:

103380416(tmem5)

POV:	109641917(tmem5)

SSEN:

122775364(rxylt1)

HHIP:

117763567(rxylt1)

LCF:	108875264(tmem5)

SDU:	111228597(tmem5)

SLAL:

111661770(rxylt1)

XGL:	120793739(rxylt1)

HCQ:	109530509(tmem5)

BPEC:

110161333(tmem5)

MALB:

109961858(tmem5)

SASA:

100380601(tmem5)

OTW:	112252554(rxylt1)

OMY:	110523037(rxylt1)

OGO:	124002735(rxylt1)

ONE:	115108969(rxylt1)

SALP:

111952823(rxylt1)

SNH:	120054086(rxylt1)

ELS:	105018139(rxylt1)

SFM:	108935981(rxylt1)

PKI:	111860961(rxylt1)

AANG:

118231063(rxylt1)

LOC:	102687159(tmem5)

PSPA:

121319998(rxylt1)

ARUT:

117419593(rxylt1)

LCM:	102347491(TMEM5)

CMK:	103179815(rxylt1)

RTP:	109927331(tmem5)

BFO:

BBEL:

CIN:

SCLV:

SPU:

APLC:

SKO:

BTAB:

CLEC:

HHAL:

NLU:

PHU:	Phum_PHUM354410

FOC:

113211456

ZNE:

110831162

CSEC:

111867064

DPX:	DAPPUDRAFT_48489

DMK:

PVM:

PJA:

HAME:

PCLA:

PTRU:

HAZT:

ISC:	IscW_ISCW021970

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:	107359888 107363073

DPTE:

DFR:

CSCU:

PTEP:

SDM:

HRO:	HELRODRAFT_191935

LGI:	LOTGIDRAFT_228735

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

MYI:

PMAX:

MMER:

OBI:

OSN:

LAK:	106150449 106167194

NVE:	5500853 5505848

EPA:	110238447 110251687

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:	124438500 124441381

HMG:

101235002

TAD:	TRIADDRAFT_19905

MBR:	MONBRDRAFT_16245

SRE:	PTSG_08361

» show all

Reference

PMID:27733679

Authors

Manya H, Yamaguchi Y, Kanagawa M, Kobayashi K, Tajiri M, Akasaka-Manya K, Kawakami H, Mizuno M, Wada Y, Toda T, Endo T

Title

The Muscular Dystrophy Gene TMEM5 Encodes a Ribitol beta1,4-Xylosyltransferase Required for the Functional Glycosylation of Dystroglycan.

Journal

J Biol Chem 291:24618-24627 (2016)
DOI:10.1074/jbc.M116.751917

Sequence

[hsa:10329]

LinkDB

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