KEGG   ORTHOLOGY: K21183
Entry
K21183                      KO                                     

Name
sgcC2, mdpC2, kedY2
Definition
peptidyl carrier protein
Module
M00827  C-1027 beta-amino acid moiety biosynthesis, tyrosine => 3-chloro-4,5-dihydroxy-beta-phenylalanyl-PCP
M00828  Maduropeptin beta-hydroxy acid moiety biosynthesis, tyrosine => 3-(4-hydroxyphenyl)-3-oxopropanoyl-PCP
M00832  Kedarcidin 2-aza-3-chloro-beta-tyrosine moiety biosynthesis, azatyrosine => 2-aza-3-chloro-beta-tyrosyl-PCP
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01059 Biosynthesis of enediyne antibiotics
    K21183  sgcC2, mdpC2, kedY2; peptidyl carrier protein
Genes
SGB: WQO_33880
SQZ: FQU76_30285
SSPO: DDQ41_30950
AJA: AJAP_16290
ACTI: UA75_18120
ACAD: UA74_17595
SAQ: Sare_2094
PFLA: Pflav_004670
PSUU: Psuf_070440
AG: ABY66003(mdpC2) AFV52209(kedY2)
Reference
PMID:12183628 (sgcC2)
  Authors
Liu W, Christenson SD, Standage S, Shen B
  Title
Biosynthesis of the enediyne antitumor antibiotic C-1027.
  Journal
Science 297:1170-3 (2002)
DOI:10.1126/science.1072110
  Sequence
[sgb:WQO_33880]
Reference
PMID:17918933 (mdpC2)
  Authors
Van Lanen SG, Oh TJ, Liu W, Wendt-Pienkowski E, Shen B
  Title
Characterization of the maduropeptin biosynthetic gene cluster from Actinomadura madurae ATCC 39144 supporting a unifying paradigm for enediyne biosynthesis.
  Journal
J Am Chem Soc 129:13082-94 (2007)
DOI:10.1021/ja073275o
  Sequence
Reference
PMID:23633564 (kedY2)
  Authors
Huang SX, Lohman JR, Huang T, Shen B
  Title
A new member of the 4-methylideneimidazole-5-one-containing aminomutase family from the enediyne kedarcidin biosynthetic pathway.
  Journal
Proc Natl Acad Sci U S A 110:8069-74 (2013)
DOI:10.1073/pnas.1304733110
  Sequence
Reference
  Authors
Van Lanen SG, Lin S, Dorrestein PC, Kelleher NL, Shen B
  Title
Substrate specificity of the adenylation enzyme SgcC1 involved in the biosynthesis of the enediyne antitumor antibiotic C-1027.
  Journal
J Biol Chem 281:29633-40 (2006)
DOI:10.1074/jbc.M605887200
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