KEGG   ORTHOLOGY: K21195
Entry
K21195                      KO                                     

Name
phnY
Definition
2-aminoethylphosphonate dioxygenase [EC:1.14.11.46]
Pathway
ko00440  Phosphonate and phosphinate metabolism
ko01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00440 Phosphonate and phosphinate metabolism
    K21195  phnY; 2-aminoethylphosphonate dioxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.11  With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
    1.14.11.46  2-aminoethylphosphonate dioxygenase
     K21195  phnY; 2-aminoethylphosphonate dioxygenase
Other DBs
RN: R10724
Genes
QSU: 111983342 112009534 112031218
SSCK: SPSK_09539
FVR: FVEG_07745
FOX: FOXG_04606
MAW: MAC_01242
MAJ: MAA_09259
PLJ: VFPFJ_04691 VFPFJ_10443
BFU: BCIN_06g00110
PSCO: LY89DRAFT_740562 LY89DRAFT_780538
NFI: NFIA_065130
ANG: ANI_1_1162024(An02g08170)
TASA: A1Q1_05374
LHA: LHA_1528
NOC: Noc_1391
NHL: Nhal_1353
NWA: Nwat_1690
BOK: DM82_2522
BOC: BG90_2211
MLO: mlr5924
ARA: Arad_7878
BJA: blr2133(blr2133)
PSWU: SY83_09970
SYND: KR52_11175
AG: ACU83549(phnY)
 » show all
Reference
  Authors
Martinez A, Tyson GW, Delong EF
  Title
Widespread known and novel phosphonate utilization pathways in marine bacteria revealed by functional screening and metagenomic analyses.
  Journal
Environ Microbiol 12:222-38 (2010)
DOI:10.1111/j.1462-2920.2009.02062.x
  Sequence
Reference
  Authors
McSorley FR, Wyatt PB, Martinez A, DeLong EF, Hove-Jensen B, Zechel DL
  Title
PhnY and PhnZ comprise a new oxidative pathway for enzymatic cleavage of a carbon-phosphorus bond.
  Journal
J Am Chem Soc 134:8364-7 (2012)
DOI:10.1021/ja302072f
LinkDB

KEGG   ENZYME: 1.14.11.46
Entry
EC 1.14.11.46               Enzyme                                 

Name
2-aminoethylphosphonate dioxygenase;
phnY (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
Sysname
(2-aminoethyl)phosphonate,2-oxoglutarate:oxygen oxidoreductase (1-hydroxylating)
Reaction(IUBMB)
(2-aminoethyl)phosphonate + 2-oxoglutarate + O2 = (2-amino-1-hydroxyethyl)phosphonate + succinate + CO2 [RN:R10724]
Reaction(KEGG)
R10724
Substrate
(2-aminoethyl)phosphonate [CPD:C03557];
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007]
Product
(2-amino-1-hydroxyethyl)phosphonate [CPD:C05678];
succinate [CPD:C00042];
CO2 [CPD:C00011]
Comment
Requires Fe2+ and ascorbate. The enzyme, characterized from an uncultured marine bacterium, is involved in a (2-aminoethyl)phosphonate degradation pathway.
History
EC 1.14.11.46 created 2014
Pathway
ec00440  Phosphonate and phosphinate metabolism
ec01100  Metabolic pathways
Orthology
K21195  2-aminoethylphosphonate dioxygenase
Genes
QSU: 111983342 112009534 112031218
SSCK: SPSK_09539
FVR: FVEG_07745
FOX: FOXG_04606
MAW: MAC_01242
MAJ: MAA_09259
PLJ: VFPFJ_04691 VFPFJ_10443
BFU: BCIN_06g00110
PSCO: LY89DRAFT_740562 LY89DRAFT_780538
NFI: NFIA_065130
ANG: ANI_1_1162024(An02g08170)
TASA: A1Q1_05374
LHA: LHA_1528
NOC: Noc_1391
NHL: Nhal_1353
NWA: Nwat_1690
BOK: DM82_2522
BOC: BG90_2211
MLO: mlr5924
ARA: Arad_7878
BJA: blr2133(blr2133)
PSWU: SY83_09970
SYND: KR52_11175
 » show all
Reference
1  [PMID:22564006]
  Authors
McSorley FR, Wyatt PB, Martinez A, DeLong EF, Hove-Jensen B, Zechel DL
  Title
PhnY and PhnZ comprise a new oxidative pathway for enzymatic cleavage of a carbon-phosphorus bond.
  Journal
J Am Chem Soc 134:8364-7 (2012)
DOI:10.1021/ja302072f
Other DBs
ExplorEnz - The Enzyme Database: 1.14.11.46
IUBMB Enzyme Nomenclature: 1.14.11.46
ExPASy - ENZYME nomenclature database: 1.14.11.46
BRENDA, the Enzyme Database: 1.14.11.46
LinkDB

KEGG   REACTION: R10724
Entry
R10724                      Reaction                               

Name
(2-aminoethyl)phosphonate,2-oxoglutarate:oxygen oxidoreductase (1-hydroxylating)
Definition
2-Aminoethylphosphonate + 2-Oxoglutarate + Oxygen <=> (2-Amino-1-hydroxyethyl)phosphonate + Succinate + CO2
Equation
Reaction class
RC01107  C03557_C05678
Enzyme
Pathway
rn00440  Phosphonate and phosphinate metabolism
rn01100  Metabolic pathways
Orthology
K21195  2-aminoethylphosphonate dioxygenase [EC:1.14.11.46]
Other DBs
RHEA: 41443
LinkDB

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