KEGG   ORTHOLOGY: K21196
Entry
K21196                      KO                                     

Name
phnZ
Definition
2-amino-1-hydroxyethylphosphonate dioxygenase (glycine-forming) [EC:1.13.11.78]
Pathway
ko00440  Phosphonate and phosphinate metabolism
ko01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00440 Phosphonate and phosphinate metabolism
    K21196  phnZ; 2-amino-1-hydroxyethylphosphonate dioxygenase (glycine-forming)
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.13  Acting on single donors with incorporation of molecular oxygen (oxygenases)
   1.13.11  With incorporation of two atoms of oxygen
    1.13.11.78  2-amino-1-hydroxyethylphosphonate dioxygenase (glycine-forming)
     K21196  phnZ; 2-amino-1-hydroxyethylphosphonate dioxygenase (glycine-forming)
Other DBs
RN: R10722
COG: COG4341
Genes
BFO: 118428300
CIN: 101242664
SPU: 100894127
APLC: 110978365
SKO: 100376109
PVM: 113811511
LGI: LOTGIDRAFT_172204
MYI: 110460342
OBI: 106870487
LAK: 106156700
EPA: 110244149
AMIL: 114975294
PDAM: 113683386
SPIS: 111325752
DGT: 114526236
QSU: 111995343
MAW: MAC_01243
MAJ: MAA_09260
CMT: CCM_06455
ANG: ANI_1_2760024(An02g08160)
SMIN: v1.2.002470.t1(symbB.v1.2.002470.t1)
PPT: PPS_4982
PPUH: B479_25155
PPUN: PP4_51980
PPUD: DW66_5375
PMON: X969_24605
PMOT: X970_24240
PFL: PFL_5886
PPRO: PPC_5834
PFS: PFLU_5807
PMAN: OU5_3801
PEN: PSEEN0270
PBA: PSEBR_a22
PSEM: TO66_29740
PSOS: POS17_5830
PANR: A7J50_5534
PSIL: PMA3_28680
LHA: LHA_1529
CVI: CV_1839
CPI: Cpin_2968
MUC: MuYL_1124
SLI: Slin_3397
FAE: FAES_5432
VG: 11257372(mg458) 14445472(H012_gp541) 9925053(L432)
AG: ACU83550(phnZ)
 » show all
Reference
  Authors
Martinez A, Tyson GW, Delong EF
  Title
Widespread known and novel phosphonate utilization pathways in marine bacteria revealed by functional screening and metagenomic analyses.
  Journal
Environ Microbiol 12:222-38 (2010)
DOI:10.1111/j.1462-2920.2009.02062.x
  Sequence
LinkDB

KEGG   ORTHOLOGY: K05915
Entry
K05915            Tight     KO                                     

Name
phnZ1
Definition
(hydroxymethyl)phosphonate/2-amino-1-hydroxyethylphosphonate dioxygenase [EC:1.13.11.89 1.13.11.78]
Pathway
ko00440  Phosphonate and phosphinate metabolism
ko01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00440 Phosphonate and phosphinate metabolism
    K05915  phnZ1; (hydroxymethyl)phosphonate/2-amino-1-hydroxyethylphosphonate dioxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.13  Acting on single donors with incorporation of molecular oxygen (oxygenases)
   1.13.11  With incorporation of two atoms of oxygen
    1.13.11.78  2-amino-1-hydroxyethylphosphonate dioxygenase (glycine-forming)
     K05915  phnZ1; (hydroxymethyl)phosphonate/2-amino-1-hydroxyethylphosphonate dioxygenase
    1.13.11.89  (hydroxymethyl)phosphonate dioxygenase
     K05915  phnZ1; (hydroxymethyl)phosphonate/2-amino-1-hydroxyethylphosphonate dioxygenase
Other DBs
RN: R10722 R12451
COG: COG4341
Genes
GMR: GmarT_03180
Reference
  Authors
Gama SR, Vogt M, Kalina T, Hupp K, Hammerschmidt F, Pallitsch K, Zechel DL
  Title
An Oxidative Pathway for Microbial Utilization of Methylphosphonic Acid as a Phosphate Source.
  Journal
ACS Chem Biol 14:735-741 (2019)
DOI:10.1021/acschembio.9b00024
  Sequence
LinkDB

KEGG   ENZYME: 1.13.11.78
Entry
EC 1.13.11.78               Enzyme                                 

Name
2-amino-1-hydroxyethylphosphonate dioxygenase (glycine-forming);
phnZ (gene name)
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
Sysname
2-amino-1-hydroxyethylphosphonate:oxygen 1-oxidoreductase (glycine-forming)
Reaction(IUBMB)
(2-amino-1-hydroxyethyl)phosphonate + O2 = glycine + phosphate [RN:R10722]
Reaction(KEGG)
R10722
Substrate
(2-amino-1-hydroxyethyl)phosphonate [CPD:C05678];
O2 [CPD:C00007]
Product
glycine [CPD:C00037];
phosphate [CPD:C00009]
Comment
Requires Fe2+. The enzyme, characterized from a marine bacterium, is involved in a 2-aminoethylphosphonate degradation pathway.
History
EC 1.13.11.78 created 2014
Pathway
ec00440  Phosphonate and phosphinate metabolism
ec01100  Metabolic pathways
Orthology
K05915  (hydroxymethyl)phosphonate/2-amino-1-hydroxyethylphosphonate dioxygenase
K21196  2-amino-1-hydroxyethylphosphonate dioxygenase (glycine-forming)
Genes
BFO: 118428300
CIN: 101242664
SPU: 100894127
APLC: 110978365
SKO: 100376109
PVM: 113811511
LGI: LOTGIDRAFT_172204
MYI: 110460342
OBI: 106870487
LAK: 106156700
EPA: 110244149
AMIL: 114975294
PDAM: 113683386
SPIS: 111325752
DGT: 114526236
QSU: 111995343
MAW: MAC_01243
MAJ: MAA_09260
CMT: CCM_06455
ANG: ANI_1_2760024(An02g08160)
SMIN: v1.2.002470.t1(symbB.v1.2.002470.t1)
PPT: PPS_4982
PPUH: B479_25155
PPUN: PP4_51980
PPUD: DW66_5375
PMON: X969_24605
PMOT: X970_24240
PFL: PFL_5886
PPRO: PPC_5834
PFS: PFLU_5807
PMAN: OU5_3801
PEN: PSEEN0270
PBA: PSEBR_a22
PSEM: TO66_29740
PSOS: POS17_5830
PANR: A7J50_5534
PSIL: PMA3_28680
LHA: LHA_1529
CVI: CV_1839
CPI: Cpin_2968
MUC: MuYL_1124
SLI: Slin_3397
FAE: FAES_5432
 » show all
Reference
1  [PMID:22564006]
  Authors
McSorley FR, Wyatt PB, Martinez A, DeLong EF, Hove-Jensen B, Zechel DL
  Title
PhnY and PhnZ comprise a new oxidative pathway for enzymatic cleavage of a carbon-phosphorus bond.
  Journal
J Am Chem Soc 134:8364-7 (2012)
DOI:10.1021/ja302072f
Reference
2  [PMID:24198335]
  Authors
Worsdorfer B, Lingaraju M, Yennawar NH, Boal AK, Krebs C, Bollinger JM Jr, Pandelia ME
  Title
Organophosphonate-degrading PhnZ reveals an emerging family of HD domain mixed-valent diiron oxygenases.
  Journal
Proc Natl Acad Sci U S A 110:18874-9 (2013)
DOI:10.1073/pnas.1315927110
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.13.11.78
IUBMB Enzyme Nomenclature: 1.13.11.78
ExPASy - ENZYME nomenclature database: 1.13.11.78
BRENDA, the Enzyme Database: 1.13.11.78
LinkDB

KEGG   REACTION: R10722
Entry
R10722                      Reaction                               

Name
2-amino-1-hydroxyethylphosphonate:oxygen 1-oxidoreductase (glycine-forming)
Definition
(2-Amino-1-hydroxyethyl)phosphonate + Oxygen <=> Glycine + Orthophosphate
Equation
Reaction class
RC03261  C00037_C05678
Enzyme
Pathway
rn00440  Phosphonate and phosphinate metabolism
rn01100  Metabolic pathways
Orthology
K05915  (hydroxymethyl)phosphonate/2-amino-1-hydroxyethylphosphonate dioxygenase [EC:1.13.11.89 1.13.11.78]
K21196  2-amino-1-hydroxyethylphosphonate dioxygenase (glycine-forming) [EC:1.13.11.78]
Other DBs
RHEA: 41447
LinkDB

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