KEGG   ORTHOLOGY: K21219
Entry
K21219                      KO                                     

Name
thiDN
Definition
hydroxymethylpyrimidine kinase / phosphomethylpyrimidine kinase / thiamine-phosphate diphosphorylase [EC:2.7.1.49 2.7.4.7 2.5.1.3]
Pathway
ko00730  Thiamine metabolism
ko01100  Metabolic pathways
ko01240  Biosynthesis of cofactors
Module
M00127  Thiamine biosynthesis, prokaryotes, AIR (+ DXP/tyrosine) => TMP/TPP
M00896  Thiamine biosynthesis, archaea, AIR (+ NAD+) => TMP/TPP
M00899  Thiamine salvage pathway, HMP/HET => TMP
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00730 Thiamine metabolism
    K21219  thiDN; hydroxymethylpyrimidine kinase / phosphomethylpyrimidine kinase / thiamine-phosphate diphosphorylase
Enzymes [BR:ko01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.3  thiamine phosphate synthase
     K21219  thiDN; hydroxymethylpyrimidine kinase / phosphomethylpyrimidine kinase / thiamine-phosphate diphosphorylase
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.49  hydroxymethylpyrimidine kinase
     K21219  thiDN; hydroxymethylpyrimidine kinase / phosphomethylpyrimidine kinase / thiamine-phosphate diphosphorylase
   2.7.4  Phosphotransferases with a phosphate group as acceptor
    2.7.4.7  phosphooxymethylpyrimidine kinase
     K21219  thiDN; hydroxymethylpyrimidine kinase / phosphomethylpyrimidine kinase / thiamine-phosphate diphosphorylase
Other DBs
RN: R03223 R03471 R04509 R10712
COG: COG0351 COG1992
GO: 0008902 0008972 0004789
Genes
DDN: DND132_0246
DSD: GD606_06665(thiD)
DSA: Desal_1774
DHY: DESAM_22422
DAS: Daes_1844
DPI: BN4_10299
DEJ: AWY79_13195
PPRF: DPRO_0943
PSEL: GM415_15090(thiD)
DSX: GD604_11660(thiD)
TTK: TST_1656(thiD)
TMA: TM0790
TMW: THMA_0809
TMQ: THMB_0809
TMX: THMC_0809
TPT: Tpet_0139
TRQ: TRQ2_0137
TNA: CTN_1788
TNP: Tnap_0140
TLE: Tlet_1753
TME: Tmel_1594
TAF: THA_1801
THER: Y592_08780
FNO: Fnod_1419
OCY: OSSY52_15610(thiDN)
MARN: LN42_04900
TAV: G4V39_04455(thiD)
MJA: MJ_0236
MMP: MMP1639
MMD: GYY_09050
MMAD: MMJJ_11980(thiD)
MAE: Maeo_0460
MVO: Mvol_1254
MKA: MK0589(thiD)
GAC: GACE_1547
GAH: GAH_00126
MEAR: Mpt1_c03150(thiDN)
MARC: AR505_0650
PFU: PF1333
PFI: PFC_05880
PHO: PH1155(PH1155)
PAB: PAB1646
PYN: PNA2_1764
PYS: Py04_0935
TKO: TK0435
TGA: TGAM_1271(thiD)
TSI: TSIB_0462
THE: GQS_02020
THM: CL1_0035
TLT: OCC_04964
THS: TES1_0593
TNU: BD01_0514
TEU: TEU_09500
PPAC: PAP_03995
MBAR: MSBR2_1128
MBAK: MSBR3_1454
MAC: MA_3197(thiD)
MMA: MM_0338
MMAC: MSMAC_0965
METM: MSMTP_2342
MTHR: MSTHT_1098
MTHE: MSTHC_2205
MHOR: MSHOH_3049
MFZ: AOB57_010930(thiD)
MBU: Mbur_2182(thiD)
MMET: MCMEM_0359
MMH: Mmah_0363
MPY: Mpsy_2779
MZI: HWN40_08755(thiD)
MTP: Mthe_0828
MCJ: MCON_0806(thiD)
MHI: Mhar_1899
MEZ: Mtc_2023(thiD)
HAL: VNG_2606G(thiD)
HSL: OE_4654F(thiDN)
HHB: Hhub_1123(thiDN)
HSU: HLASF_1503(thiD2)
HSF: HLASA_1490(thiD2)
SALR: FQU85_03525(thiD)
HALR: EFA46_013160(thiD)
HMA: rrnAC2449(thiD)
HHI: HAH_2882(thiD)
HALJ: G9465_05525(thiD)
NPH: NP_0546A(thiDN)
NMO: Nmlp_3884(thiDN)
HUT: Huta_0491
HALA: Hrd1104_03805(thiD)
HMU: Hmuk_0364
HALZ: E5139_05105(thiD)
HALL: LC1Hm_2892(thiDN)
HSN: DV733_06810(thiD)
HRR: HZS55_11725(thiD)
HPEL: HZS54_14065(thiD)
HLT: I7X12_02440(thiD)
HARC: HARCEL1_03120(thiD)
HME: HFX_2683(thiD)
HAQ: DU484_00925(thiD)
HAJ: DU500_01490(thiD)
HAER: DU502_16980(thiD)
HRA: EI982_13975(thiD)
HLM: DV707_08680(thiD)
HLA: Hlac_2988
HALP: DOS48_04635(thiD)
HALB: EKH57_11765(thiD)
HEZZ: EO776_00410(thiD)
SRUB: C2R22_14585(thiD)
HALN: B4589_006720(thiD)
HALG: HUG10_08605(thiD)
HALU: HUG12_18830(thiD)
HDF: AArcSl_2693(thiDN)
HTU: Htur_3232
HJT: DVR14_12795(thiD)
HALY: HYG82_09440(thiD)
NMG: Nmag_1282(thiDN)
NAT: NJ7G_2232
NVR: FEJ81_03720(thiD)
NPL: FGF80_07090(thiD)
SALI: L593_03780
NBG: DV706_09585(thiD)
NAS: GCU68_02470(thiD)
APE: APE_2400.1(thiDN)
ACJ: ACAM_1502(thiDN)
SMR: Smar_0049
IHO: Igni_0888
IIS: EYM_07800
DKA: DKAM_0714
IAG: Igag_1669
HBU: Hbut_1459
STO: STK_05260(thiD)
SOH: D1869_02465(thiD)
SSO: SSO2393(thiD-2)
SOL: Ssol_0200
SSOA: SULA_0192(thiD)
SSOL: SULB_0193(thiD)
SSOF: SULC_0192(thiD)
SAI: Saci_0953
SID: M164_0204
SII: LD85_0189
SIH: SiH_0191
SIR: SiRe_0185
SIC: SiL_0178
SULE: GFS03_02475(thiD)
MSE: Msed_0646
MCN: Mcup_1524
MHK: DFR87_02965(thiD)
MPRU: DFR88_03350(thiD)
MTEN: GWK48_09145(thiD)
AHO: Ahos_2188
ABRI: DFR85_00670(thiD)
ASUL: DFR86_03170(thiD)
AAMB: D1866_05920(thiD)
SAZO: D1868_10230(thiD)
STEP: IC006_2571
PAI: PAE2535
PIS: Pisl_1419
PCL: Pcal_0240
PAS: Pars_0839
PYR: P186_2074
POG: Pogu_1494
TNE: Tneu_1881
CMA: Cmaq_0452
TTN: TTX_0857(thiD)
TUZ: TUZN_0613
VDI: Vdis_2402
VMO: VMUT_0747
ASC: ASAC_1274
ACIA: SE86_07465
NMR: Nmar_0542
NIW: Nisw_02165(thiD)
NCL: C5F47_02780(thiD)
NOX: C5F49_02960(thiD)
NUE: C5F50_04155(thiD)
NCT: NMSP_1131(thiDN)
NIC: DSQ20_03015(thiD)
NGA: Ngar_c15420(thiD)
NVN: NVIE_006780(thiD)
NEV: NTE_02040
TAA: NMY3_02518(thiD)
NFN: NFRAN_0101(thiD)
NCV: NCAV_1388(thiD)
NBV: T478_0467(thiD)
NDV: NDEV_0535
CCAI: NAS2_1199
KCR: Kcr_0867
BARC: AOA65_2405(thiDN)
BARB: AOA66_0398(thiDN)
 » show all
Reference
  Authors
Morett E, Korbel JO, Rajan E, Saab-Rincon G, Olvera L, Olvera M, Schmidt S, Snel B, Bork P
  Title
Systematic discovery of analogous enzymes in thiamin biosynthesis.
  Journal
Nat Biotechnol 21:790-5 (2003)
DOI:10.1038/nbt834
  Sequence
[tma:TM0790]
Reference
  Authors
Hayashi M, Kobayashi K, Esaki H, Konno H, Akaji K, Tazuya K, Yamada K, Nakabayashi T, Nosaka K
  Title
Enzymatic and structural characterization of an archaeal thiamin phosphate synthase.
  Journal
Biochim Biophys Acta 1844:803-9 (2014)
DOI:10.1016/j.bbapap.2014.02.017
  Sequence
[pcl:Pcal_0240]
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