KEGG   ORTHOLOGY: K21255
Entry
K21255                      KO                                     

Name
calO6
Definition
orsellinic acid C2-O-methyltransferase [EC:2.1.1.-]
Pathway
ko01059  Biosynthesis of enediyne antibiotics
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Module
M00833  Calicheamicin biosynthesis, calicheamicinone => calicheamicin
M00834  Calicheamicin orsellinate moiety biosynthesis, malonyl-CoA => orsellinate-ACP => 5-iodo-2,3-dimethoxyorsellinate-ACP
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01059 Biosynthesis of enediyne antibiotics
    K21255  calO6; orsellinic acid C2-O-methyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.-  
     K21255  calO6; orsellinic acid C2-O-methyltransferase
Other DBs
RN: R11413
Genes
SAQ: Sare_2028
AG: AAM70356(calO6)
Reference
  Authors
Ahlert J, Shepard E, Lomovskaya N, Zazopoulos E, Staffa A, Bachmann BO, Huang K, Fonstein L, Czisny A, Whitwam RE, Farnet CM, Thorson JS
  Title
The calicheamicin gene cluster and its iterative type I enediyne PKS.
  Journal
Science 297:1173-6 (2002)
DOI:10.1126/science.1072105
  Sequence
Reference
  Authors
Singh S, Nandurkar NS, Thorson JS
  Title
Characterization of the calicheamicin orsellinate C2-O-methyltransferase CalO6.
  Journal
Chembiochem 15:1418-21 (2014)
DOI:10.1002/cbic.201402119
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