KEGG   ORTHOLOGY: K21258
Entry
K21258                      KO                                     

Name
calO1
Definition
orsellinic acid C3-O-methyltransferase [EC:2.1.1.-]
Pathway
ko01059  Biosynthesis of enediyne antibiotics
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Module
M00833  Calicheamicin biosynthesis, calicheamicinone => calicheamicin
M00834  Calicheamicin orsellinate moiety biosynthesis, malonyl-CoA => orsellinate-ACP => 5-iodo-2,3-dimethoxyorsellinate-ACP
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01059 Biosynthesis of enediyne antibiotics
    K21258  calO1; orsellinic acid C3-O-methyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.-  
     K21258  calO1; orsellinic acid C3-O-methyltransferase
Other DBs
RN: R11416
Genes
SAQ: Sare_2170
AG: AAM70343(calO1)
Reference
  Authors
Ahlert J, Shepard E, Lomovskaya N, Zazopoulos E, Staffa A, Bachmann BO, Huang K, Fonstein L, Czisny A, Whitwam RE, Farnet CM, Thorson JS
  Title
The calicheamicin gene cluster and its iterative type I enediyne PKS.
  Journal
Science 297:1173-6 (2002)
DOI:10.1126/science.1072105
  Sequence
Reference
  Authors
Chang A, Singh S, Bingman CA, Thorson JS, Phillips GN Jr
  Title
Structural characterization of CalO1: a putative orsellinic acid methyltransferase in the calicheamicin-biosynthetic pathway.
  Journal
Acta Crystallogr D Biol Crystallogr 67:197-203 (2011)
DOI:10.1107/S090744491100360X
LinkDB

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