KEGG   ORTHOLOGY: K21357
Entry
K21357                      KO                                     

Name
ULK1
Definition
serine/threonine-protein kinase ULK1 [EC:2.7.11.1]
Pathway
ko04137  Mitophagy - animal
ko04140  Autophagy - animal
ko04150  mTOR signaling pathway
ko04152  AMPK signaling pathway
ko04211  Longevity regulating pathway
ko05010  Alzheimer disease
ko05014  Amyotrophic lateral sclerosis
ko05016  Huntington disease
ko05017  Spinocerebellar ataxia
ko05022  Pathways of neurodegeneration - multiple diseases
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04152 AMPK signaling pathway
    K21357  ULK1; serine/threonine-protein kinase ULK1
   04150 mTOR signaling pathway
    K21357  ULK1; serine/threonine-protein kinase ULK1
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K21357  ULK1; serine/threonine-protein kinase ULK1
   04137 Mitophagy - animal
    K21357  ULK1; serine/threonine-protein kinase ULK1
 09150 Organismal Systems
  09149 Aging
   04211 Longevity regulating pathway
    K21357  ULK1; serine/threonine-protein kinase ULK1
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K21357  ULK1; serine/threonine-protein kinase ULK1
   05014 Amyotrophic lateral sclerosis
    K21357  ULK1; serine/threonine-protein kinase ULK1
   05016 Huntington disease
    K21357  ULK1; serine/threonine-protein kinase ULK1
   05017 Spinocerebellar ataxia
    K21357  ULK1; serine/threonine-protein kinase ULK1
   05022 Pathways of neurodegeneration - multiple diseases
    K21357  ULK1; serine/threonine-protein kinase ULK1
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K21357  ULK1; serine/threonine-protein kinase ULK1
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K21357  ULK1; serine/threonine-protein kinase ULK1
   03029 Mitochondrial biogenesis
    K21357  ULK1; serine/threonine-protein kinase ULK1
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K21357  ULK1; serine/threonine-protein kinase ULK1
Protein kinases [BR:ko01001]
 Serine/threonine kinases: Other
  ULK family [OT]
   K21357  ULK1; serine/threonine-protein kinase ULK1
Membrane trafficking [BR:ko04131]
 Autophagy
  Autophagosome formation proteins
   ULK complex
    K21357  ULK1; serine/threonine-protein kinase ULK1
Mitochondrial biogenesis [BR:ko03029]
 Mitochondrial quality control factors
  Mitophagy factors
   Parkin-independent mechanism factors
    K21357  ULK1; serine/threonine-protein kinase ULK1
Genes
HSA: 8408(ULK1)
PTR: 744289(ULK1)
PPS: 100970765(ULK1)
GGO: 101149691(ULK1)
PON: 100450395(ULK1)
NLE: 100583005(ULK1)
MCC: 709746(ULK1)
MCF: 102141167(ULK1)
CSAB: 103239428(ULK1)
RRO: 104674321(ULK1)
RBB: 108527503(ULK1)
CJC: 100403342(ULK1)
SBQ: 101030459(ULK1)
MMU: 22241(Ulk1)
MCAL: 110294005(Ulk1)
MPAH: 110339107(Ulk1)
RNO: 360827(Ulk1)
MUN: 110553155(Ulk1)
CGE: 100772932(Ulk1)
NGI: 103750609(Ulk1)
HGL: 101714353(Ulk1)
CCAN: 109697545(Ulk1)
OCU: 100350803(ULK1)
TUP: 102477255(ULK1)
CFA: 477437(ULK1)
VVP: 112911606(ULK1)
AML: 100470276(ULK1)
UMR: 103678902(ULK1)
UAH: 113266853(ULK1)
ORO: 101366573(ULK1)
ELK: 111140006
FCA: 101098658(ULK1)
PTG: 102952269(ULK1)
PPAD: 109260065(ULK1)
AJU: 106979514(ULK1)
BTA: 526310(ULK1)
BOM: 102277562(ULK1)
BIU: 109571223(ULK1)
BBUB: 102398206(ULK1)
CHX: 102173325(ULK1)
OAS: 101117701(ULK1)
SSC: 100151990(ULK1)
CFR: 102508563(ULK1)
CDK: 105094622(ULK1)
BACU: 103000929(ULK1)
LVE: 103075192(ULK1)
OOR: 101281996(ULK1)
DLE: 111186827(ULK1)
PCAD: 102990173(ULK1)
EPZ: 103553436(ULK1)
EAI: 106843858(ULK1)
MYB: 102240341(ULK1)
MYD: 102767979(ULK1)
MNA: 107529676(ULK1)
HAI: 109396788(ULK1)
DRO: 112310681(ULK1)
PALE: 102893241(ULK1)
RAY: 107511543(ULK1)
MJV: 108399379(ULK1)
LAV: 100677118(ULK1)
TMU: 101357581
MDO: 100028481(ULK1)
SHR: 100934149(ULK1)
PCW: 110220320(ULK1)
OAA: 100093196(ULK1)
GGA: 416800(ULK1)
MGP: 100548157(ULK1)
CJO: 107321083(ULK1)
NMEL: 110406441(ULK1)
APLA: 101797231(ULK1)
ACYG: 106031210(ULK1)
TGU: 100226619(ULK1)
LSR: 110478078(ULK1)
SCAN: 103818101(ULK1)
GFR: 102038562(ULK1)
FAB: 101809001(ULK1)
PHI: 102112005(ULK1)
PMAJ: 107211711(ULK1)
CCAE: 111936486(ULK1)
CCW: 104688633(ULK1)
ETL: 114066581(ULK1)
FPG: 101920864(ULK1)
FCH: 102059652(ULK1)
CLV: 102092693(ULK1)
EGZ: 104127189(ULK1)
NNI: 104019896(ULK1)
ACUN: 113486041(ULK1)
PADL: 103912402(ULK1)
AAM: 106497614(ULK1)
ASN: 102372779(ULK1)
AMJ: 102565589(ULK1)
PSS: 102443852(ULK1)
CMY: 102945384(ULK1)
CPIC: 101949936(ULK1)
ACS: 100561587(ulk1)
PVT: 110076575(ULK1)
PBI: 103056702(ULK1)
PMUR: 107299178(ULK1)
PMUA: 114586111(ULK1)
GJA: 107108284(ULK1)
XLA: 108707144(ulk1.S) 108716267(ulk1.L)
XTR: 100127200(ulk1)
NPR: 108788565(ULK1)
DRE: 100170793(ulk1a) 558848(ulk1b)
IPU: 108265551(ULK2) 108279004(ulk1)
PHYP: 113535536(ulk1) 113546005
AMEX: 103021360 103042154(ulk1)
EEE: 113573444(ulk1) 113584871
TRU: 101076837 105419003(ulk1)
NCC: 104943547 104961519(ulk1)
ONL: 100699294 100702529(ulk1)
OLA: 101155703(ulk1) 101167046
XMA: 102220165(ulk1) 102238002
XCO: 114149469(ulk1) 114155070
PRET: 103469663 103473584(ulk1)
CVG: 107081776(ulk1) 107090965
NFU: 107374177 107397066(ulk1)
KMR: 108232687(ulk1) 108247312
ALIM: 106513539(ulk1) 106528300
CSEM: 103389416(ulk1)
POV: 109626411(ulk1) 109633574
SDU: 111231860 111233068(ulk1)
HCQ: 109511601 109515115(ulk1)
ELS: 105014825(ulk1) 105024833
SFM: 108921936(ulk1)
PKI: 111856566(ulk1)
LCM: 102351366(ULK1)
CMK: 103188023(ulk1)
RTP: 109924985
SHX: MS3_01308
EGL: EGR_03447
ABP: AGABI1DRAFT62752(AGABI1DRAFT_62752)
ABV: AGABI2DRAFT120057(AGABI2DRAFT_120057)
SMIN: v1.2.026219.t1(symbB.v1.2.026219.t1)
 » show all
Reference
PMID:9693035
  Authors
Kuroyanagi H, Yan J, Seki N, Yamanouchi Y, Suzuki Y, Takano T, Muramatsu M, Shirasawa T
  Title
Human ULK1, a novel serine/threonine kinase related to UNC-51 kinase of Caenorhabditis elegans: cDNA cloning, expression, and chromosomal assignment.
  Journal
Genomics 51:76-85 (1998)
DOI:10.1006/geno.1998.5340
  Sequence
[hsa:8408]
Reference
  Authors
Egan DF, Shackelford DB, Mihaylova MM, Gelino S, Kohnz RA, Mair W, Vasquez DS, Joshi A, Gwinn DM, Taylor R, Asara JM, Fitzpatrick J, Dillin A, Viollet B, Kundu M, Hansen M, Shaw RJ
  Title
Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy.
  Journal
Science 331:456-61 (2011)
DOI:10.1126/science.1196371
  Sequence
[hsa:8408]
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