KEGG   ORTHOLOGY: K21425
Entry
K21425            Tight     KO                                     

Name
RAS
Definition
rosmarinate synthase [EC:2.3.1.140]
Pathway
ko00350  Tyrosine metabolism
ko01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00350 Tyrosine metabolism
    K21425  RAS; rosmarinate synthase
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.140  rosmarinate synthase
     K21425  RAS; rosmarinate synthase
Other DBs
RN: R03374
GO: 0050266
Genes
AG: CBW35684(RAS)
Reference
  Authors
Weitzel C, Petersen M
  Title
Cloning and characterisation of rosmarinic acid synthase from Melissa officinalis L.
  Journal
Phytochemistry 72:572-8 (2011)
DOI:10.1016/j.phytochem.2011.01.039
  Sequence
LinkDB

KEGG   ENZYME: 2.3.1.140
Entry
EC 2.3.1.140                Enzyme                                 

Name
rosmarinate synthase;
rosmarinic acid synthase;
caffeoyl-coenzyme A:3,4-dihydroxyphenyllactic acid caffeoyltransferase;
4-coumaroyl-CoA:4-hydroxyphenyllactic acid 4-coumaroyl transferase;
RAS (gene name)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
caffeoyl-CoA:(R)-3-(3,4-dihydroxyphenyl)lactate 2'-O-caffeoyl-transferase
Reaction(IUBMB)
caffeoyl-CoA + (R)-3-(3,4-dihydroxyphenyl)lactate = CoA + rosmarinate [RN:R03374]
Reaction(KEGG)
R03374
Substrate
caffeoyl-CoA [CPD:C00323];
(R)-3-(3,4-dihydroxyphenyl)lactate [CPD:C22038]
Product
CoA [CPD:C00010];
rosmarinate [CPD:C01850]
Comment
Involved, with EC 1.1.1.237 (hydroxyphenylpyruvate reductase) in the biosynthesis of rosmarinic acid. Characterized from the plant Melissa officinalis L. (lemon balm).
History
EC 2.3.1.140 created 1992, modified 2013
Pathway
ec00350  Tyrosine metabolism
ec01100  Metabolic pathways
Orthology
K21425  rosmarinate synthase
Reference
1
  Authors
Petersen, M. and Alfermann, A.W.
  Title
Two new enzymes of rosmarinic acid biosynthesis from cell cultures of Coleus blumei: hydroxyphenylpyruvate reductase and rosmarinic acid synthase.
  Journal
Z Naturforsch C: Biosci 43:501-504 (1988)
Reference
2
  Authors
Petersen, M. S.
  Title
Characterization of rosmarinic acid synthase from cell cultures of Coleus blumei.
  Journal
Phytochemistry 30:2877-2881 (1991)
Reference
3  [PMID:21354582]
  Authors
Weitzel C, Petersen M
  Title
Cloning and characterisation of rosmarinic acid synthase from Melissa officinalis L.
  Journal
Phytochemistry 72:572-8 (2011)
DOI:10.1016/j.phytochem.2011.01.039
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.140
IUBMB Enzyme Nomenclature: 2.3.1.140
ExPASy - ENZYME nomenclature database: 2.3.1.140
BRENDA, the Enzyme Database: 2.3.1.140
CAS: 117590-80-4
LinkDB

KEGG   REACTION: R03374
Entry
R03374                      Reaction                               

Name
caffeoyl-CoA:3-(3,4-dihydroxyphenyl)lactate 2'-O-caffeoyltransferase
Definition
Caffeoyl-CoA + (R)-3-(3,4-Dihydroxyphenyl)lactate <=> CoA + Rosmarinate
Equation
Reaction class
RC00004  C00010_C00323
RC00037  C01850_C22038
Enzyme
Pathway
rn00350  Tyrosine metabolism
rn01100  Metabolic pathways
Orthology
K21425  rosmarinate synthase [EC:2.3.1.140]
Other DBs
RHEA: 22347
LinkDB

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