KEGG   ORTHOLOGY: K21888
Entry
K21888                      KO                                     

Name
DHAR
Definition
glutathione dehydrogenase/transferase [EC:1.8.5.1 2.5.1.18]
Pathway
ko00053  Ascorbate and aldarate metabolism
ko00480  Glutathione metabolism
ko01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00053 Ascorbate and aldarate metabolism
    K21888  DHAR; glutathione dehydrogenase/transferase
  09106 Metabolism of other amino acids
   00480 Glutathione metabolism
    K21888  DHAR; glutathione dehydrogenase/transferase
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters
    K21888  DHAR; glutathione dehydrogenase/transferase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.8  Acting on a sulfur group of donors
   1.8.5  With a quinone or similar compound as acceptor
    1.8.5.1  glutathione dehydrogenase (ascorbate)
     K21888  DHAR; glutathione dehydrogenase/transferase
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.18  glutathione transferase
     K21888  DHAR; glutathione dehydrogenase/transferase
Transporters [BR:ko02000]
 Other transporters
  Pores ion channels
   K21888  DHAR; glutathione dehydrogenase/transferase
Other DBs
RN: R01108 R03522
GO: 0045174 0004364
TC: 1.A.12.2.1
Genes
PCAN: 112571966
MYI: 110441083
TAD: TRIADDRAFT_56715
ATH: AT1G19550 AT1G19570(DHAR1) AT1G75270(DHAR2) AT5G16710(DHAR3)
ALY: 110227884 9304537 9323647 9326409
CRB: 17884168 17895904 17898354
CSAT: 104702262 104705963 104713173 104735705 104740653 104751400 104756300 104769957 104776068
EUS: EUTSA_v10008761mg EUTSA_v10014453mg EUTSA_v10019864mg
BRP: 103835841 103846305 103851061 103852942 103872760
BNA: 106346950 106357292 106369834 106371989 106375652 106387685 106397189 106401061 106431231 106440767 106449347
GMX: 100306061(DHAR4) 100805216 100819803(DHAR1) 732557(DHAR3)
LJA: Lj0g3v0326719.1(Lj0g3v0326719.1) Lj0g3v0326719.2(Lj0g3v0326719.2) Lj5g3v2288530.1(Lj5g3v2288530.1)
JCU: 105634679(DHAR) 105638586
VVI: 100233050(DHAR) 100258402
SLY: 101254215 778229(DHAR1) 778343(DHAR2)
SOT: 102577622(DHAR) 102577766(DHAR2) 102598042
CANN: 107870482 107871328(DHAR)
CCAV: 112519586
DOSA: Os05t0116100-01(Os05g0116100) Os06t0232600-01(Os06g0232600)
ATS: 109765491(LOC109765491) 109782434(LOC109782434)
ZMA: 100191219(dhar3) 100273125(dhar1) 100285047(dhar4) 100382696(dhar2)
MNG: MNEG_0969
APRO: F751_6478
 » show all
Reference
  Authors
Dixon DP, Davis BG, Edwards R
  Title
Functional divergence in the glutathione transferase superfamily in plants. Identification of two classes with putative functions in redox homeostasis in Arabidopsis thaliana.
  Journal
J Biol Chem 277:30859-69 (2002)
DOI:10.1074/jbc.M202919200
  Sequence
Reference
  Authors
Noshi M, Yamada H, Hatanaka R, Tanabe N, Tamoi M, Shigeoka S
  Title
Arabidopsis dehydroascorbate reductase 1 and 2 modulate redox states of ascorbate-glutathione cycle in the cytosol in response to photooxidative stress.
  Journal
Biosci Biotechnol Biochem 81:523-533 (2017)
DOI:10.1080/09168451.2016.1256759
LinkDB

KEGG   ENZYME: 1.8.5.1
Entry
EC 1.8.5.1                  Enzyme                                 

Name
glutathione dehydrogenase (ascorbate);
dehydroascorbic reductase;
dehydroascorbic acid reductase;
glutathione dehydroascorbate reductase;
DHA reductase ;
dehydroascorbate reductase;
GDOR;
glutathione:dehydroascorbic acid oxidoreductase
Class
Oxidoreductases;
Acting on a sulfur group of donors;
With a quinone or similar compound as acceptor
Sysname
glutathione:dehydroascorbate oxidoreductase
Reaction(IUBMB)
2 glutathione + dehydroascorbate = glutathione disulfide + ascorbate [RN:R01108]
Reaction(KEGG)
R01108
Substrate
glutathione [CPD:C00051];
dehydroascorbate [CPD:C05422]
Product
glutathione disulfide [CPD:C00127];
ascorbate [CPD:C00072]
History
EC 1.8.5.1 created 1961
Pathway
ec00053  Ascorbate and aldarate metabolism
ec00480  Glutathione metabolism
ec01100  Metabolic pathways
Orthology
K21888  glutathione dehydrogenase/transferase
Genes
PCAN: 112571966
MYI: 110441083
TAD: TRIADDRAFT_56715
ATH: AT1G19550 AT1G19570(DHAR1) AT1G75270(DHAR2) AT5G16710(DHAR3)
ALY: 110227884 9304537 9323647 9326409
CRB: 17884168 17895904 17898354
CSAT: 104702262 104705963 104713173 104735705 104740653 104751400 104756300 104769957 104776068
EUS: EUTSA_v10008761mg EUTSA_v10014453mg EUTSA_v10019864mg
BRP: 103835841 103846305 103851061 103852942 103872760
BNA: 106346950 106357292 106369834 106371989 106375652 106387685 106397189 106401061 106431231 106440767 106449347
GMX: 100306061(DHAR4) 100805216 100819803(DHAR1) 732557(DHAR3)
LJA: Lj0g3v0326719.1(Lj0g3v0326719.1) Lj0g3v0326719.2(Lj0g3v0326719.2) Lj5g3v2288530.1(Lj5g3v2288530.1)
JCU: 105634679(DHAR) 105638586
VVI: 100233050(DHAR) 100258402
SLY: 101254215 778229(DHAR1) 778343(DHAR2)
SOT: 102577622(DHAR) 102577766(DHAR2) 102598042
CANN: 107870482 107871328(DHAR)
CCAV: 112519586
DOSA: Os05t0116100-01(Os05g0116100) Os06t0232600-01(Os06g0232600)
ATS: 109765491(LOC109765491) 109782434(LOC109782434)
ZMA: 100191219(dhar3) 100273125(dhar1) 100285047(dhar4) 100382696(dhar2)
MNG: MNEG_0969
APRO: F751_6478
 » show all
Reference
1  [PMID:16747320]
  Authors
Crook EM
  Title
The system dehydroascorbic acid-glutathione.
  Journal
Biochem J 35:226-36 (1941)
DOI:10.1042/bj0350226
Other DBs
ExplorEnz - The Enzyme Database: 1.8.5.1
IUBMB Enzyme Nomenclature: 1.8.5.1
ExPASy - ENZYME nomenclature database: 1.8.5.1
BRENDA, the Enzyme Database: 1.8.5.1
CAS: 9026-38-4
LinkDB

KEGG   REACTION: R01108
Entry
R01108                      Reaction                               

Name
glutathione:dehydroascorbate oxidoreductase
Definition
Dehydroascorbate + 2 Glutathione <=> Glutathione disulfide + Ascorbate
Equation
Reaction class
RC00011  C00051_C00127
RC00092  C00072_C05422
Enzyme
Pathway
rn00053  Ascorbate and aldarate metabolism
rn00480  Glutathione metabolism
rn01100  Metabolic pathways
Orthology
K21888  glutathione dehydrogenase/transferase [EC:1.8.5.1 2.5.1.18]
Other DBs
RHEA: 24427
LinkDB

DBGET integrated database retrieval system