KEGG   ORTHOLOGY: K22271Help
Entry
K22271                      KO                                     

Name
Core
Definition
HCV core protein
Pathway
ko05160  Hepatitis C
ko05203  Viral carcinogenesis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09161 Cancer: overview
   05203 Viral carcinogenesis
    K22271  Core; HCV core protein
  09172 Infectious disease: viral
   05160 Hepatitis C
    K22271  Core; HCV core protein
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   03200 Viral proteins
    K22271  Core; HCV core protein
Viral proteins [BR:ko03200]
 +ssRNA viruses
  Hepatitis C virus
   K22271  Core; HCV core protein
BRITE hierarchy
Genes
AG: NP_751919(p21)
TaxonomyKoalaUniProt
Reference
  Authors
Gouklani H, Beyer C, Drummer H, Gowans EJ, Netter HJ, Haqshenas G
  Title
Identification of specific regions in hepatitis C virus core, NS2 and NS5A that genetically interact with p7 and co-ordinate infectious virus production.
  Journal
J Viral Hepat 20:e66-71 (2013)
DOI:10.1111/jvh.12004
  Sequence
Reference
  Authors
Scheel TK, Rice CM
  Title
Understanding the hepatitis C virus life cycle paves the way for highly effective therapies.
  Journal
Nat Med 19:837-49 (2013)
DOI:10.1038/nm.3248
LinkDB All DBs

KEGG   Homo sapiens (human): 10197Help
Entry
10197             CDS       T01001                                 

Gene name
PSME3, HEL-S-283, Ki, PA28-gamma, PA28G, PA28gamma, REG-GAMMA
Definition
(RefSeq) proteasome activator subunit 3
  KO
K06698  proteasome activator subunit 3 (PA28 gamma)
Organism
hsa  Homo sapiens (human)
Pathway
hsa03050  Proteasome
hsa04612  Antigen processing and presentation
hsa05160  Hepatitis C
Network
nt06163  Hepatitis C virus (HCV)
nt06263  Hepatocellular carcinoma
  Element
N00530  HCV core to RXRA/LXRA-mediated transcription
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   03050 Proteasome
    10197 (PSME3)
 09150 Organismal Systems
  09151 Immune system
   04612 Antigen processing and presentation
    10197 (PSME3)
 09160 Human Diseases
  09172 Infectious disease: viral
   05160 Hepatitis C
    10197 (PSME3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03051 Proteasome [BR:hsa03051]
    10197 (PSME3)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    10197 (PSME3)
Proteasome [BR:hsa03051]
 Eukaryotic proteasome
  Regulatory particles
   PA28 (11S REG)
    10197 (PSME3)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   10197 (PSME3)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: PA28_beta PA28_alpha TMF_TATA_bd
Motif
Other DBs
NCBI-GeneID: 10197
NCBI-ProteinID: NP_005780
OMIM: 605129
HGNC: 9570
Ensembl: ENSG00000131467
Vega: OTTHUMG00000180654
Pharos: P61289(Tbio)
UniProt: P61289 V9HWJ8
LinkDB All DBs
Position
17q21.31
AA seq 254 aa AA seqDB search
MASLLKVDQEVKLKVDSFRERITSEAEDLVANFFPKKLLELDSFLKEPILNIHDLTQIHS
DMNLPVPDPILLTNSHDGLDGPTYKKRRLDECEEAFQGTKVFVMPNGMLKSNQQLVDIIE
KVKPEIRLLIEKCNTVKMWVQLLIPRIEDGNNFGVSIQEETVAELRTVESEAASYLDQIS
RYYITRAKLVSKIAKYPHVEDYRRTVTEIDEKEYISLRLIISELRNQYVTLHDMILKNIE
KIKRPRSSNAETLY
NT seq 765 nt NT seq  +upstreamnt  +downstreamnt
atggcctcgttgctgaaggtggatcaggaagtgaagctcaaggttgattctttcagggag
cggatcacaagtgaggcagaagacttggtggcaaattttttcccaaagaagttattagaa
cttgatagttttctgaaggaaccaatcttaaacatccatgacctaactcagatccactct
gacatgaatctcccagtccctgaccccattcttctcaccaatagccatgatggactggat
ggtcccacttataagaagcgaaggttggatgagtgtgaagaagccttccaaggaaccaag
gtgtttgtgatgcccaatgggatgctgaaaagcaaccagcagctggtggacattattgag
aaagtgaaacctgagatccggctgttgattgagaaatgtaacacggtcaaaatgtgggta
cagctcctgattcccaggatagaagatggaaacaactttggggtgtccattcaggaggaa
acagttgcagagctaagaactgttgagagtgaagctgcatcttatctggaccagatttct
agatattatattacaagagccaaattggtttctaaaatagctaaatatccccatgtggag
gactatcgccgcaccgtgacagagattgatgagaaagaatatatcagccttcggctcatc
atatcagagctgaggaatcaatatgtcactctacatgacatgatcctgaaaaatatcgag
aagatcaaacggccccggagcagcaatgcagagactctgtactga

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