KEGG   ORTHOLOGY: K22273Help
Entry
K22273                      KO                                     

Name
NS3
Definition
HCV serine protease NS3 [EC:3.4.21.98]
Pathway
ko05160  Hepatitis C
ko05203  Viral carcinogenesis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09161 Cancer: overview
   05203 Viral carcinogenesis
    K22273  NS3; HCV serine protease NS3
  09172 Infectious disease: viral
   05160 Hepatitis C
    K22273  NS3; HCV serine protease NS3
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   03200 Viral proteins
    K22273  NS3; HCV serine protease NS3
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.21  Serine endopeptidases
    3.4.21.98  hepacivirin
     K22273  NS3; HCV serine protease NS3
Viral proteins [BR:ko03200]
 +ssRNA viruses
  Hepatitis C virus
   K22273  NS3; HCV serine protease NS3
BRITE hierarchy
Genes
AG: NP_803144(NS3)
TaxonomyKoalaUniProt
Reference
PMID:8861916
  Authors
Love RA, Parge HE, Wickersham JA, Hostomsky Z, Habuka N, Moomaw EW, Adachi T, Hostomska Z
  Title
The crystal structure of hepatitis C virus NS3 proteinase reveals a trypsin-like fold and a structural zinc binding site.
  Journal
Cell 87:331-42 (1996)
  Sequence
Reference
  Authors
Scheel TK, Rice CM
  Title
Understanding the hepatitis C virus life cycle paves the way for highly effective therapies.
  Journal
Nat Med 19:837-49 (2013)
DOI:10.1038/nm.3248
LinkDB All DBs

KEGG   ORTHOLOGY: K22274Help
Entry
K22274                      KO                                     

Name
NS4A
Definition
HCV non-structural protein 4A
Pathway
ko05160  Hepatitis C
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09172 Infectious disease: viral
   05160 Hepatitis C
    K22274  NS4A; HCV non-structural protein 4A
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   03200 Viral proteins
    K22274  NS4A; HCV non-structural protein 4A
Viral proteins [BR:ko03200]
 +ssRNA viruses
  Hepatitis C virus
   K22274  NS4A; HCV non-structural protein 4A
BRITE hierarchy
Genes
AG: NP_751925(NS4A)
TaxonomyKoalaUniProt
Reference
  Authors
Murayama A, Sugiyama N, Suzuki R, Moriyama M, Nakamura N, Mochizuki H, Wakita T, Kato T
  Title
Amino Acid Mutations in the NS4A Region of Hepatitis C Virus Contribute to Viral Replication and Infectious Virus Production.
  Journal
J Virol 91:e02124-16 (2017)
DOI:10.1128/JVI.02124-16
  Sequence
Reference
  Authors
Scheel TK, Rice CM
  Title
Understanding the hepatitis C virus life cycle paves the way for highly effective therapies.
  Journal
Nat Med 19:837-49 (2013)
DOI:10.1038/nm.3248
LinkDB All DBs

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