KEGG   ORTHOLOGY: K22327
Entry
K22327            Tight     KO                                     

Name
TYRDC-2
Definition
4-hydroxyphenylacetaldehyde synthase [EC:4.1.1.108]
Pathway
ko00350  Tyrosine metabolism
ko00950  Isoquinoline alkaloid biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00350 Tyrosine metabolism
    K22327  TYRDC-2; 4-hydroxyphenylacetaldehyde synthase
  09110 Biosynthesis of other secondary metabolites
   00950 Isoquinoline alkaloid biosynthesis
    K22327  TYRDC-2; 4-hydroxyphenylacetaldehyde synthase
Enzymes [BR:ko01000]
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.1  Carboxy-lyases
    4.1.1.108  4-hydroxyphenylacetaldehyde synthase
     K22327  TYRDC-2; 4-hydroxyphenylacetaldehyde synthase
Other DBs
RN: R11917
Genes
AG: AAA33860(TYRDC-2)
Reference
  Authors
Torrens-Spence MP, Gillaspy G, Zhao B, Harich K, White RH, Li J
  Title
Biochemical evaluation of a parsley tyrosine decarboxylase results in a novel 4-hydroxyphenylacetaldehyde synthase enzyme.
  Journal
Biochem Biophys Res Commun 418:211-6 (2012)
DOI:10.1016/j.bbrc.2011.12.124
  Sequence
LinkDB

KEGG   ENZYME: 4.1.1.108
Entry
EC 4.1.1.108                Enzyme                                 

Name
4-hydroxyphenylacetaldehyde synthase;
TYRDC-2 (gene name)
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
Sysname
L-tyrosine carboxy-lyase (oxidative-deaminating)
Reaction(IUBMB)
L-tyrosine + O2 + H2O = (4-hydroxyphenyl)acetaldehyde + CO2 + NH3 + H2O2 [RN:R11917]
Reaction(KEGG)
R11917
Substrate
L-tyrosine [CPD:C00082];
O2 [CPD:C00007];
H2O [CPD:C00001]
Product
4-hydroxyphenylacetaldehyde [CPD:C03765];
CO2 [CPD:C00011];
NH3 [CPD:C00014];
H2O2 [CPD:C00027]
Comment
A pyridoxal 5'-phosphate protein. The enzyme, isolated from the the plant Petroselinum crispum (parsley), catalyses the production of 4-hydroxyphenylacetaldehyde directly from L-tyrosine. Tyramine is not formed as an intermediate. The enzyme has a low activity with L-dopa (cf. EC 4.1.1.107, 3,4-dihydroxyphenylacetaldehyde synthase).
History
EC 4.1.1.108 created 2017
Pathway
ec00350  Tyrosine metabolism
ec00950  Isoquinoline alkaloid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K22327  4-hydroxyphenylacetaldehyde synthase
Reference
1  [PMID:22266321]
  Authors
Torrens-Spence MP, Gillaspy G, Zhao B, Harich K, White RH, Li J
  Title
Biochemical evaluation of a parsley tyrosine decarboxylase results in a novel 4-hydroxyphenylacetaldehyde synthase enzyme.
  Journal
Biochem Biophys Res Commun 418:211-6 (2012)
DOI:10.1016/j.bbrc.2011.12.124
  Sequence
Reference
2  [PMID:23204519]
  Authors
Torrens-Spence MP, Liu P, Ding H, Harich K, Gillaspy G, Li J
  Title
Biochemical evaluation of the decarboxylation and decarboxylation-deamination activities of plant aromatic amino acid decarboxylases.
  Journal
J Biol Chem 288:2376-87 (2013)
DOI:10.1074/jbc.M112.401752
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.108
IUBMB Enzyme Nomenclature: 4.1.1.108
ExPASy - ENZYME nomenclature database: 4.1.1.108
BRENDA, the Enzyme Database: 4.1.1.108
LinkDB

KEGG   REACTION: R11917
Entry
R11917                      Reaction                               

Name
L-tyrosine carboxy-lyase (oxidative-deaminating)
Definition
L-Tyrosine + Oxygen + H2O <=> 4-Hydroxyphenylacetaldehyde + CO2 + Ammonia + Hydrogen peroxide
Equation
Reaction class
RC03515  C00082_C03765
Enzyme
Pathway
rn00350  Tyrosine metabolism
rn00950  Isoquinoline alkaloid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K22327  4-hydroxyphenylacetaldehyde synthase [EC:4.1.1.108]
Other DBs
RHEA: 55531
LinkDB

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