KEGG   ORTHOLOGY: K22329
Entry
K22329                      KO                                     

Name
TDC-1
Definition
tyrosine decarboxylase [EC:4.1.1.25]
Pathway
ko00350  Tyrosine metabolism
ko01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00350 Tyrosine metabolism
    K22329  TDC-1; tyrosine decarboxylase
Enzymes [BR:ko01000]
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.1  Carboxy-lyases
    4.1.1.25  tyrosine decarboxylase
     K22329  TDC-1; tyrosine decarboxylase
Other DBs
GO: 0004837
Genes
SPU: 594040
APLC: 110976950 110976951 110977004 110986576
SKO: 100370006
DME: Dmel_CG30446(Tdc2)
DER: 6541166 6541418
DSE: 6607876
DSI: Dsimw501_GD10312(Dsim_GD10312) Dsimw501_GD10313(Dsim_GD10313)
DYA: Dyak_GE24598 Dyak_GE24609
DAN: 6496636
DSR: 110189728 110189729
DVI: 6626705
BMOR: 101745224
BMAN: 114250590
PMAC: 106710721
HAW: 110375714
TNL: 113504421
PXY: 105380584
API: 100164582
DNX: 107166908
AGS: 114120413
RMD: 113549264
BTAB: 109044218
CLEC: 106662160
PVM: 113823929
TUT: 107364473
DPTE: 113797060
CEL: CELE_K01C8.3(tdc-1)
CBR: CBG00668(Cbr-tdc-1)
BMY: Bm1_42020
PCAN: 112557030
CRG: 105343976
MYI: 110450166
OBI: 106872068
LAK: 106169254
SHX: MS3_02440
 » show all
Reference
  Authors
Alkema MJ, Hunter-Ensor M, Ringstad N, Horvitz HR
  Title
Tyramine Functions independently of octopamine in the Caenorhabditis elegans nervous system.
  Journal
Neuron 46:247-60 (2005)
DOI:10.1016/j.neuron.2005.02.024
  Sequence
LinkDB

KEGG   ORTHOLOGY: K01592
Entry
K01592                      KO                                     

Name
TYDC
Definition
tyrosine decarboxylase [EC:4.1.1.25]
Pathway
ko00350  Tyrosine metabolism
ko00950  Isoquinoline alkaloid biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00350 Tyrosine metabolism
    K01592  TYDC; tyrosine decarboxylase
  09110 Biosynthesis of other secondary metabolites
   00950 Isoquinoline alkaloid biosynthesis
    K01592  TYDC; tyrosine decarboxylase
Enzymes [BR:ko01000]
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.1  Carboxy-lyases
    4.1.1.25  tyrosine decarboxylase
     K01592  TYDC; tyrosine decarboxylase
Other DBs
RN: R00736 R02080
GO: 0004837
Genes
ATH: AT4G28680(TYRDC)
ALY: 9305556
CRB: 17880524
CSAT: 104722011
BRP: 103854232
BNA: 106401881 111206442
BOE: 106301496
RSZ: 108840444
Reference
  Authors
Lehmann T, Pollmann S
  Title
Gene expression and characterization of a stress-induced tyrosine decarboxylase from Arabidopsis thaliana.
  Journal
FEBS Lett 583:1895-900 (2009)
DOI:10.1016/j.febslet.2009.05.017
  Sequence
[ath:AT4G28680]
Reference
  Authors
Gutensohn M, Klempien A, Kaminaga Y, Nagegowda DA, Negre-Zakharov F, Huh JH, Luo H, Weizbauer R, Mengiste T, Tholl D, Dudareva N
  Title
Role of aromatic aldehyde synthase in wounding/herbivory response and flower scent production in different Arabidopsis ecotypes.
  Journal
Plant J 66:591-602 (2011)
DOI:10.1111/j.1365-313X.2011.04515.x
LinkDB

KEGG   ORTHOLOGY: K22330
Entry
K22330                      KO                                     

Name
tyrDC
Definition
tyrosine decarboxylase [EC:4.1.1.25]
Pathway
ko00350  Tyrosine metabolism
ko01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00350 Tyrosine metabolism
    K22330  tyrDC; tyrosine decarboxylase
Enzymes [BR:ko01000]
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.1  Carboxy-lyases
    4.1.1.25  tyrosine decarboxylase
     K22330  tyrDC; tyrosine decarboxylase
Other DBs
GO: 0004837
Genes
VIG: BKP57_05785
VPN: A21D_02269(ddc)
PLV: ERIC2_c03820 ERIC2_c03880
PLUT: EI981_13145(tdc)
LBR: LVIS_2213
LBK: LVISKB_2286
LKO: ABN16_05945
LZY: LZ3411_0102
LROS: LROSL1_0287
LZH: D1B17_03980
LFT: FG051_11765(tdc)
EFA: EF0634
EFL: EF62_1003
EFS: EFS1_0482
EFQ: DR75_2583(tdc)
ENE: ENT_24840
EFM: M7W_577
EHR: EHR_03460
EMU: EMQU_0384
EDU: LIU_00045
ETH: CK496_01640(tdc)
MPX: MPD5_1444
VCP: H9L18_09730(tdc)
CML: BN424_2873(tdc)
CBV: U729_1871(tdc)
AG: AAM46082(tyrDC)
 » show all
Reference
  Authors
Connil N, Le Breton Y, Dousset X, Auffray Y, Rince A, Prevost H
  Title
Identification of the Enterococcus faecalis tyrosine decarboxylase operon involved in tyramine production.
  Journal
Appl Environ Microbiol 68:3537-44 (2002)
DOI:10.1128/AEM.68.7.3537-3544.2002
  Sequence
LinkDB

KEGG   ORTHOLOGY: K18933
Entry
K18933                      KO                                     

Name
mfnA, adc
Definition
tyrosine decarboxylase / aspartate 1-decarboxylase [EC:4.1.1.25 4.1.1.11]
Pathway
ko00350  Tyrosine metabolism
ko00410  beta-Alanine metabolism
ko00680  Methane metabolism
ko00770  Pantothenate and CoA biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00680 Methane metabolism
    K18933  mfnA, adc; tyrosine decarboxylase / aspartate 1-decarboxylase
  09105 Amino acid metabolism
   00350 Tyrosine metabolism
    K18933  mfnA, adc; tyrosine decarboxylase / aspartate 1-decarboxylase
  09106 Metabolism of other amino acids
   00410 beta-Alanine metabolism
    K18933  mfnA, adc; tyrosine decarboxylase / aspartate 1-decarboxylase
  09108 Metabolism of cofactors and vitamins
   00770 Pantothenate and CoA biosynthesis
    K18933  mfnA, adc; tyrosine decarboxylase / aspartate 1-decarboxylase
Enzymes [BR:ko01000]
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.1  Carboxy-lyases
    4.1.1.11  aspartate 1-decarboxylase
     K18933  mfnA, adc; tyrosine decarboxylase / aspartate 1-decarboxylase
    4.1.1.25  tyrosine decarboxylase
     K18933  mfnA, adc; tyrosine decarboxylase / aspartate 1-decarboxylase
Other DBs
RN: R00489 R00736
COG: COG0076
GO: 0004837 0004068
Genes
SRR: SerAS9_4289
SRY: M621_21860
SPLY: Q5A_021830(ddc_3)
SRS: SerAS12_4290
SRA: SerAS13_4290
PPSY: AOC04_17040
LLO: LLO_2358
LSH: CAB17_17095
MEC: Q7C_1781
MME: Marme_2120
CCE: Ccel_1039
SHY: SHJG_8487
GLJ: GKIL_0849
SACI: Sinac_0199
SPER: EW093_04660(mfnA) EW093_08085(mfnA)
ACA: ACP_2295
ABAS: ACPOL_2465
FLM: MY04_4046
FIN: KQS_13585
FBU: UJ101_00805(mfnA|adc)
MJA: MJ_0050
MMP: MMP0131
MMD: GYY_00665
MMAK: MMKA1_01360(mfmA)
MMAO: MMOS7_01620(mfmA)
MMAD: MMJJ_09550(ddc)
MAE: Maeo_1008
MVO: Mvol_1332
MTH: MTH_1116
MMG: MTBMA_c15000(mfnA)
METC: MTCT_1010
MWO: MWSIV6_1508(mfnA)
METE: tca_01072
METK: FVF72_06000(mfnA)
MTHM: FZP57_07215(mfnA)
MST: Msp_0329(mfnA)
MRU: mru_1896(mfnA)
MSI: Msm_0987
MEB: Abm4_1501(mfnA)
MMIL: sm9_1948(mfnA)
MEYE: TL18_09200
MOL: YLM1_1352
METH: MBMB1_1647(mfnA)
MFC: BRM9_0901(mfnA)
MFI: DSM1535_0868(mfnA)
MCUB: MCBB_1953(mfnA)
MFV: Mfer_0124
MKA: MK1500
AFU: AF_2004
FPL: Ferp_1624
GAC: GACE_1678
GAH: GAH_00469
ABI: Aboo_1436
PFU: PF1159
PFI: PFC_05020
PHO: PH0937(PH0937)
PAB: PAB1578
PYN: PNA2_1618
PYS: Py04_1152
TKO: TK1814
TON: TON_1710
TGA: TGAM_2137(mfnA)
TSI: TSIB_0460
THE: GQS_06765
THA: TAM4_357
THM: CL1_0978
TLT: OCC_10103
THS: TES1_1892
TNU: BD01_1348
TEU: TEU_02775
PPAC: PAP_09195
MBAR: MSBR2_3469
MBAK: MSBR3_3475
MAC: MA_0006
MMA: MM_1317
MMAC: MSMAC_3369
METM: MSMTP_3249
MTHR: MSTHT_1822
MTHE: MSTHC_1464
MHOR: MSHOH_4092
MFZ: AOB57_008380(mfnA)
MBU: Mbur_1732
MMET: MCMEM_2203
MMH: Mmah_2032
MPY: Mpsy_1730
MZI: HWN40_01010(mfnA)
MTP: Mthe_1636
MCJ: MCON_2882
MHI: Mhar_0758
MHU: Mhun_2611
MLA: Mlab_1545
MBG: BN140_0541(mfnA)
MEMA: MMAB1_0678(mfnA)
MPI: Mpet_0341
MBN: Mboo_2166
MPL: Mpal_2080
MPD: MCP_0399(mfnA)
MEZ: Mtc_0699(mfnA)
RCI: RCIX1543(mfnA)
HAL: VNG_0327G(gadD)
HSL: OE_1498R(mfnA)
HHB: Hhub_1472(mfnA)
HALH: HTSR_1425(gadD)
HHSR: HSR6_1497(mfnA)
HSU: HLASF_0642(gadD)
HSF: HLASA_0638(gadD)
SALR: FQU85_02085(mfnA)
HALR: EFA46_006260(mfnA)
HMA: rrnAC1798(gadD)
HHI: HAH_2325(gadB)
HALJ: G9465_07335(mfnA)
NPH: NP_1194A(panD)
NMO: Nmlp_3238(mfnA)
HUT: Huta_2743
HTI: HTIA_2492
HALA: Hrd1104_02165(mfnA)
HMU: Hmuk_2995
HALZ: E5139_02250(mfnA)
HALL: LC1Hm_2418(mfnA)
HSN: DV733_10045(mfnA)
HRR: HZS55_08855(mfnA)
HPEL: HZS54_09975(mfnA)
HARC: HARCEL1_05395(mfnA)
HVO: HVO_0811(panD)
HME: HFX_0780
HALE: G3A49_04080(mfnA)
HAER: DU502_04300(mfnA)
HLM: DV707_11510(mfnA)
HALM: FCF25_10535(mfnA)
HLA: Hlac_0591
HALP: DOS48_02805(mfnA)
HALB: EKH57_08460(mfnA)
HEZZ: EO776_04065(mfnA)
HALQ: Hrr1229_003030(mfnA)
HALG: HUG10_01995(mfnA)
HALU: HUG12_15070(mfnA)
HTU: Htur_0805
HJT: DVR14_06700(mfnA)
HALY: HYG82_19550(mfnA)
NMG: Nmag_2599(panD)
NAT: NJ7G_4186
NVR: FEJ81_16035(mfnA)
NPL: FGF80_15110(mfnA)
SALI: L593_04020
NBG: DV706_03355(mfnA)
NAS: GCU68_10160(mfnA)
APE: APE_0412
ACJ: ACAM_0297
SMR: Smar_1292
DKA: DKAM_0021
TAG: Tagg_0191
HBU: Hbut_0224
ASC: ASAC_0977
BARB: AOA66_0496(mfnA)
LOKI: Lokiarch_04140(mfnA_1) Lokiarch_53170(mfnA_2)
PSYT: DSAG12_00578(mfnA)
 » show all
Reference
  Authors
Wang Y, Xu H, White RH
  Title
beta-alanine biosynthesis in Methanocaldococcus jannaschii.
  Journal
J Bacteriol 196:2869-75 (2014)
DOI:10.1128/JB.01784-14
  Sequence
[mja:MJ_0050]
Reference
  Authors
Tomita H, Yokooji Y, Ishibashi T, Imanaka T, Atomi H
  Title
An archaeal glutamate decarboxylase homolog functions as an aspartate decarboxylase and is involved in beta-alanine and coenzyme A biosynthesis.
  Journal
J Bacteriol 196:1222-30 (2014)
DOI:10.1128/JB.01327-13
  Sequence
[tko:TK1814]
LinkDB

KEGG   ENZYME: 4.1.1.25
Entry
EC 4.1.1.25                 Enzyme                                 

Name
tyrosine decarboxylase;
L-tyrosine decarboxylase;
L-(-)-tyrosine apodecarboxylase;
L-tyrosine carboxy-lyase
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
Sysname
L-tyrosine carboxy-lyase (tyramine-forming)
Reaction(IUBMB)
L-tyrosine = tyramine + CO2 [RN:R00736]
Reaction(KEGG)
R00736;
(other) R02080
Substrate
L-tyrosine [CPD:C00082]
Product
tyramine [CPD:C00483];
CO2 [CPD:C00011]
Comment
A pyridoxal-phosphate protein. The bacterial enzyme also acts on 3-hydroxytyrosine and, more slowly, on 3-hydroxyphenylalanine.
History
EC 4.1.1.25 created 1961
Pathway
ec00350  Tyrosine metabolism
ec00680  Methane metabolism
ec00950  Isoquinoline alkaloid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K01592  tyrosine decarboxylase
K18933  tyrosine decarboxylase / aspartate 1-decarboxylase
K22329  tyrosine decarboxylase
K22330  tyrosine decarboxylase
Genes
SPU: 594040
APLC: 110976950 110976951 110977004 110986576
SKO: 100370006
DME: Dmel_CG30446(Tdc2)
DER: 6541166 6541418
DSE: 6607876
DSI: Dsimw501_GD10312(Dsim_GD10312) Dsimw501_GD10313(Dsim_GD10313)
DYA: Dyak_GE24598 Dyak_GE24609
DAN: 6496636
DSR: 110189728 110189729
DVI: 6626705
BMOR: 101745224
BMAN: 114250590
PMAC: 106710721
HAW: 110375714
TNL: 113504421
PXY: 105380584
API: 100164582
DNX: 107166908
AGS: 114120413
RMD: 113549264
BTAB: 109044218
CLEC: 106662160
PVM: 113823929
TUT: 107364473
DPTE: 113797060
CEL: CELE_K01C8.3(tdc-1)
CBR: CBG00668(Cbr-tdc-1)
BMY: Bm1_42020
PCAN: 112557030
CRG: 105343976
MYI: 110450166
OBI: 106872068
LAK: 106169254
SHX: MS3_02440
ATH: AT4G28680(TYRDC)
ALY: 9305556
CRB: 17880524
CSAT: 104722011
BRP: 103854232
BOE: 106301496
RSZ: 108840444
SPLY: Q5A_021830(ddc_3)
LLO: LLO_2358
MEC: Q7C_1781
VPN: A21D_02269(ddc)
PLUT: EI981_13145(tdc)
LBR: LVIS_2213
LFT: FG051_11765(tdc)
EFA: EF0634
EFL: EF62_1003
EFS: EFS1_0482
EFQ: DR75_2583(tdc)
ENE: ENT_24840
EFM: M7W_577
EHR: EHR_03460
EMU: EMQU_0384
EDU: LIU_00045
ETH: CK496_01640(tdc)
MPX: MPD5_1444
VCP: H9L18_09730(tdc)
CML: BN424_2873(tdc)
CBV: U729_1871(tdc)
CCE: Ccel_1039
SHY: SHJG_8487
GLJ: GKIL_0849
SACI: Sinac_0199
SPER: EW093_04660(mfnA) EW093_08085(mfnA)
ACA: ACP_2295
ABAS: ACPOL_2465
FLM: MY04_4046
FIN: KQS_13585
FBU: UJ101_00805(mfnA|adc)
MJA: MJ_0050
MMP: MMP0131
MMD: GYY_00665
MMAK: MMKA1_01360(mfmA)
MMAO: MMOS7_01620(mfmA)
MMAD: MMJJ_09550(ddc)
MAE: Maeo_1008
MVO: Mvol_1332
MTH: MTH_1116
MMG: MTBMA_c15000(mfnA)
METC: MTCT_1010
MWO: MWSIV6_1508(mfnA)
METE: tca_01072
METK: FVF72_06000(mfnA)
MTHM: FZP57_07215(mfnA)
MST: Msp_0329(mfnA)
MRU: mru_1896(mfnA)
MSI: Msm_0987
MEB: Abm4_1501(mfnA)
MMIL: sm9_1948(mfnA)
MEYE: TL18_09200
MOL: YLM1_1352
METH: MBMB1_1647(mfnA)
MFC: BRM9_0901(mfnA)
MFI: DSM1535_0868(mfnA)
MCUB: MCBB_1953(mfnA)
MFV: Mfer_0124
MKA: MK1500
AFU: AF_2004
FPL: Ferp_1624
GAC: GACE_1678
GAH: GAH_00469
ABI: Aboo_1436
PFU: PF1159
PFI: PFC_05020
PHO: PH0937(PH0937)
PAB: PAB1578
PYN: PNA2_1618
PYS: Py04_1152
TKO: TK1814
TON: TON_1710
TGA: TGAM_2137(mfnA)
TSI: TSIB_0460
THE: GQS_06765
THA: TAM4_357
THM: CL1_0978
TLT: OCC_10103
THS: TES1_1892
TNU: BD01_1348
TEU: TEU_02775
PPAC: PAP_09195
MBAR: MSBR2_3469
MBAK: MSBR3_3475
MAC: MA_0006
MMA: MM_1317
MMAC: MSMAC_3369
METM: MSMTP_3249
MTHR: MSTHT_1822
MTHE: MSTHC_1464
MHOR: MSHOH_4092
MFZ: AOB57_008380(mfnA)
MBU: Mbur_1732
MMET: MCMEM_2203
MMH: Mmah_2032
MPY: Mpsy_1730
MZI: HWN40_01010(mfnA)
MTP: Mthe_1636
MCJ: MCON_2882
MHI: Mhar_0758
MHU: Mhun_2611
MLA: Mlab_1545
MBG: BN140_0541(mfnA)
MEMA: MMAB1_0678(mfnA)
MPI: Mpet_0341
MBN: Mboo_2166
MPL: Mpal_2080
MPD: MCP_0399(mfnA)
MEZ: Mtc_0699(mfnA)
RCI: RCIX1543(mfnA)
HAL: VNG_0327G(gadD)
HSL: OE_1498R(mfnA)
HHB: Hhub_1472(mfnA)
HALH: HTSR_1425(gadD)
HHSR: HSR6_1497(mfnA)
HSU: HLASF_0642(gadD)
HSF: HLASA_0638(gadD)
SALR: FQU85_02085(mfnA)
HALR: EFA46_006260(mfnA)
HMA: rrnAC1798(gadD)
HHI: HAH_2325(gadB)
HALJ: G9465_07335(mfnA)
NPH: NP_1194A(panD)
NMO: Nmlp_3238(mfnA)
HUT: Huta_2743
HTI: HTIA_2492
HALA: Hrd1104_02165(mfnA)
HMU: Hmuk_2995
HALZ: E5139_02250(mfnA)
HALL: LC1Hm_2418(mfnA)
HSN: DV733_10045(mfnA)
HRR: HZS55_08855(mfnA)
HPEL: HZS54_09975(mfnA)
HARC: HARCEL1_05395(mfnA)
HVO: HVO_0811(panD)
HME: HFX_0780
HALE: G3A49_04080(mfnA)
HAER: DU502_04300(mfnA)
HLM: DV707_11510(mfnA)
HALM: FCF25_10535(mfnA)
HLA: Hlac_0591
HALP: DOS48_02805(mfnA)
HALB: EKH57_08460(mfnA)
HEZZ: EO776_04065(mfnA)
HALQ: Hrr1229_003030(mfnA)
HALG: HUG10_01995(mfnA)
HALU: HUG12_15070(mfnA)
HTU: Htur_0805
HJT: DVR14_06700(mfnA)
HALY: HYG82_19550(mfnA)
NMG: Nmag_2599(panD)
NAT: NJ7G_4186
NVR: FEJ81_16035(mfnA)
NPL: FGF80_15110(mfnA)
SALI: L593_04020
NBG: DV706_03355(mfnA)
NAS: GCU68_10160(mfnA)
APE: APE_0412
ACJ: ACAM_0297
SMR: Smar_1292
DKA: DKAM_0021
TAG: Tagg_0191
HBU: Hbut_0224
ASC: ASAC_0977
BARB: AOA66_0496(mfnA)
LOKI: Lokiarch_04140(mfnA_1) Lokiarch_53170(mfnA_2)
PSYT: DSAG12_00578(mfnA)
 » show all
Reference
1  [PMID:18871240]
  Authors
McGILVERY RW, COHEN PP
  Title
The decarboxylation of L-phenylalanine by Streptococcus faecalis R.
  Journal
J Biol Chem 174:813-6 (1948)
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.25
IUBMB Enzyme Nomenclature: 4.1.1.25
ExPASy - ENZYME nomenclature database: 4.1.1.25
BRENDA, the Enzyme Database: 4.1.1.25
CAS: 9002-09-9
LinkDB

KEGG   REACTION: R00736
Entry
R00736                      Reaction                               

Name
L-tyrosine carboxy-lyase (tyramine-forming)
Definition
L-Tyrosine <=> Tyramine + CO2
Equation
Reaction class
RC00299  C00082_C00483
Enzyme
4.1.1.25        4.1.1.28
Pathway
rn00350  Tyrosine metabolism
rn00680  Methane metabolism
rn00950  Isoquinoline alkaloid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K01592  tyrosine decarboxylase [EC:4.1.1.25]
K01593  aromatic-L-amino-acid/L-tryptophan decarboxylase [EC:4.1.1.28 4.1.1.105]
K18933  tyrosine decarboxylase / aspartate 1-decarboxylase [EC:4.1.1.25 4.1.1.11]
Other DBs
RHEA: 14348
LinkDB

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