KEGG   ORTHOLOGY: K23741
Entry
K23741                      KO                                     

Name
MAN1B, MNS3
Definition
endoplasmic reticulum Man9GlcNAc2 1,2-alpha-mannosidase [EC:3.2.1.209]
Pathway
ko00510  N-Glycan biosynthesis
ko00513  Various types of N-glycan biosynthesis
ko01100  Metabolic pathways
ko04141  Protein processing in endoplasmic reticulum
Module
M00073  N-glycan precursor trimming
M00074  N-glycan biosynthesis, high-mannose type
Disease
H00768  Autosomal recessive mental retardation
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09107 Glycan biosynthesis and metabolism
   00510 N-Glycan biosynthesis
    K23741  MAN1B, MNS3; endoplasmic reticulum Man9GlcNAc2 1,2-alpha-mannosidase
   00513 Various types of N-glycan biosynthesis
    K23741  MAN1B, MNS3; endoplasmic reticulum Man9GlcNAc2 1,2-alpha-mannosidase
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K23741  MAN1B, MNS3; endoplasmic reticulum Man9GlcNAc2 1,2-alpha-mannosidase
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K23741  MAN1B, MNS3; endoplasmic reticulum Man9GlcNAc2 1,2-alpha-mannosidase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.2  Glycosylases
   3.2.1  Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
    3.2.1.209  endoplasmic reticulum Man9GlcNAc2 1,2-alpha-mannosidase
     K23741  MAN1B, MNS3; endoplasmic reticulum Man9GlcNAc2 1,2-alpha-mannosidase
Membrane trafficking [BR:ko04131]
 Endoplasmic reticulum (ER) - Golgi transport
  Forward pathways
   ER-Golgi intermediate compartment (ERGIC) proteins
    K23741  MAN1B, MNS3; endoplasmic reticulum Man9GlcNAc2 1,2-alpha-mannosidase
Other DBs
RN: R06722
CAZy: GH47
Genes
HSA: 11253(MAN1B1)
PTR: 473099(MAN1B1)
PPS: 100987343(MAN1B1)
GGO: 101134859(MAN1B1)
PON: 100432279(MAN1B1)
NLE: 100594686(MAN1B1)
MCC: 706918(MAN1B1)
MCF: 101867098(MAN1B1)
CSAB: 103239582(MAN1B1)
RRO: 104669636(MAN1B1)
RBB: 108542887(MAN1B1)
CJC: 100392624(MAN1B1)
SBQ: 101032054(MAN1B1)
MMU: 227619(Man1b1)
MCAL: 110289782(Man1b1)
MPAH: 110317719(Man1b1)
RNO: 499751(Man1b1)
MUN: 110556996(Man1b1)
CGE: 100756512
NGI: 103732606 103741172(Man1b1)
HGL: 101724891(Man1b1)
CCAN: 109697987(Man1b1)
TUP: 102470543(MAN1B1)
VVP: 112911405(MAN1B1)
AML: 100478118
UMR: 103675308(MAN1B1)
PTG: 102948947(MAN1B1)
PPAD: 109260237(MAN1B1)
AJU: 106989099(MAN1B1) 113597246
BTA: 100336900(MAN1B1) 107131137(MAN1B1)
CHX: 102182048(MAN1B1) 106501835
OAS: 105605821 105605822(MAN1B1)
SSC: 100627465(MAN1B1)
CFR: 102513732(MAN1B1)
CDK: 105106772(MAN1B1) 105106783
BACU: 103003282 103008754(MAN1B1)
LVE: 103086557(MAN1B1)
OOR: 101275150(MAN1B1)
DLE: 111176994(MAN1B1)
ECB: 100147103(MAN1B1) 100147680
EPZ: 103568009(MAN1B1)
EAI: 106845522(MAN1B1)
MYB: 102240083(MAN1B1)
MYD: 102775495(MAN1B1)
MNA: 107536151(MAN1B1)
HAI: 109381800(MAN1B1)
DRO: 112306395(MAN1B1)
PALE: 102890593(MAN1B1)
RAY: 107503110(MAN1B1)
MJV: 108406826(MAN1B1)
LAV: 100664627(MAN1B1) 100670902
TMU: 101354994
MDO: 100022731(MAN1B1)
SHR: 100918683(MAN1B1)
PCW: 110205295(MAN1B1)
OAA: 100080650(MAN1B1)
GGA: 417296(MAN1B1)
MGP: 100543997(MAN1B1)
CJO: 107321628(MAN1B1)
NMEL: 110407012(MAN1B1)
APLA: 101803362(MAN1B1)
ACYG: 106037118(MAN1B1)
TGU: 100223461(MAN1B1)
LSR: 110472180(MAN1B1)
SCAN: 103819092(MAN1B1)
GFR: 102031555(MAN1B1)
FAB: 101816081(MAN1B1)
PHI: 102103624(MAN1B1)
PMAJ: 107212037(MAN1B1)
CCAE: 111936881(MAN1B1)
CCW: 104688195(MAN1B1)
ETL: 114064126(MAN1B1)
FPG: 101914433(MAN1B1)
FCH: 102045806(MAN1B1)
CLV: 102083787(MAN1B1)
EGZ: 104124017(MAN1B1)
NNI: 104018375(MAN1B1)
ACUN: 113486627(MAN1B1)
PADL: 103915501(MAN1B1)
AAM: 106494264(MAN1B1)
ASN: 102387590(MAN1B1)
AMJ: 102567138(MAN1B1)
PSS: 102455673(MAN1B1)
CMY: 102942408(MAN1B1)
CPIC: 101947106(MAN1B1)
ACS: 100562395(man1b1)
PVT: 110078803(MAN1B1)
PBI: 103052908(MAN1B1)
PMUR: 107295058(MAN1B1)
TSR: 106542597(MAN1B1)
PMUA: 114589499(MAN1B1)
GJA: 107123282(MAN1B1)
XLA: 447291(man1b1.L)
XTR: 100145194(man1b1)
NPR: 108797130(MAN1B1)
DRE: 556237(man1b1b) 562592(man1b1a)
IPU: 108255760(man1b1) 108279088
AMEX: 103022471(man1b1) 103024141
EEE: 113573453 113577930(man1b1)
LCO: 104923806 104930877(man1b1)
NCC: 104944586(man1b1)
MZE: 101475381(man1b1)
OLA: 101156826(man1b1) 101168136
XMA: 102232900(man1b1) 102236792
NFU: 107375119
KMR: 108241416 108245625(man1b1)
POV: 109639093(man1b1) 109641232
LCF: 108878392(man1b1) 108889011
SDU: 111221245 111226918(man1b1)
SLAL: 111647914(man1b1) 111650117
HCQ: 109527092(man1b1)
BPEC: 110154656(man1b1) 110164288
SFM: 108922690 108938629(man1b1)
PKI: 111854001 111857531(man1b1)
LCM: 102347754(MAN1B1)
CMK: 103180403(man1b1)
RTP: 109927301(man1b1)
BFO: 118420800
CIN: 100180827
APLC: 110984825
SKO: 100378677
DME: Dmel_CG11874(alpha-Man-Ib)
DER: 6555014
DSE: 6612651
DSI: Dsimw501_GD17996(Dsim_GD17996)
DAN: 6501495
DSR: 110177400
DPE: 6587772
DMN: 108155025
DAZ: 108609054
DNV: 108656217
DHE: 111599442
DVI: 6632758
MDE: 101889535
LCQ: 111690671
AALB: 109415549
AME: 413579
BIM: 100746318
BTER: 100651817
CCAL: 108622226
OBB: 114874226
SOC: 105204046
MPHA: 105832593
AEC: 105149600
ACEP: 105622350
PBAR: 105426911
VEM: 105568559
HST: 105184363
DQU: 106749327
CFO: 105248014
LHU: 105669682
PGC: 109855950
OBO: 105284082
PCF: 106784288
NVI: 100119267
CSOL: 105360197
MDL: 103575736
TCA: 659709
DPA: 109541778
ATD: 109598739
NVL: 108565052
BMOR: 101746534
BMAN: 114244560
PMAC: 106717133
PRAP: 110997563
HAW: 110377795
TNL: 113493937
PXY: 105381786
API: 100158868
DNX: 107171166
AGS: 114130037
RMD: 113553488
BTAB: 109029927
CLEC: 106662400
ZNE: 110838192
FCD: 110856238
PVM: 113818476
TUT: 107368943
DPTE: 113792907
PTEP: 107453367
CEL: CELE_T03G11.4(mans-3)
CBR: CBG14624
TSP: Tsp_04164
PCAN: 112575110
CRG: 105334865
MYI: 110447565
OBI: 106884360
EGL: EGR_00365
EPA: 110237771
ADF: 107335017
AMIL: 114946959
SPIS: 111332673
DGT: 114519075
HMG: 100198486
ATH: AT1G30000(MNS3)
ALY: 9326907
CRB: 17898338
RSZ: 108806417
THJ: 104812670
CPAP: 110807600
CIT: 102616435
TCC: 18596509
EGR: 104440790
VRA: 106775885
VAR: 108343148
VUN: 114187820
CCAJ: 109789197
CAM: 101515695
LJA: Lj6g3v1934090.1(Lj6g3v1934090.1)
ADU: 107468140
AIP: 107622562
LANG: 109345269
FVE: 101313190
RCN: 112164535
PPER: 18780386
PMUM: 103325119
PAVI: 110773985
PXB: 103951272
ZJU: 107413762
CSV: 101216212
CMO: 103484372
MCHA: 111015717
RCU: 8264122
JCU: 105633984
HBR: 110651587
POP: 7472574
PEU: 105118639
JRE: 108988627
VVI: 100243430
SLY: 101246787
SPEN: 107011307
SOT: 102583221
CANN: 107859093
NSY: 104249918
NTO: 104097810
NAU: 109216453
INI: 109192025
SIND: 105175706
OEU: 111402240
HAN: 110911812
LSV: 111880716
CCAV: 112526325
BVG: 104883805
SOE: 110794113
NNU: 104613507
OSA: 4338088
DOSA: Os05t0209100-01(Os05g0209100)
OBR: 102699961
BDI: 100820902
ATS: 109759492(LOC109759492)
SBI: 8055739
ZMA: 100282405(cl335_1)
SITA: 101773458
DCT: 110116511
PEQ: 110022272
AOF: 109828813
ATR: 18435237
PPP: 112287912
CRE: CHLREDRAFT_178232(AMD1)
VCN: VOLCADRAFT_119746(amd1)
APRO: F751_6268
MIS: MICPUN_112689(MANA)
SCE: YJR131W(MNS1)
ERC: Ecym_5170
KMX: KLMA_40509(MNS1)
NCS: NCAS_0J02160(NCAS0J02160)
NDI: NDAI_0J02870(NDAI0J02870)
TPF: TPHA_0L00320(TPHA0L00320)
TBL: TBLA_0B06140(TBLA0B06140)
TDL: TDEL_0D00600(TDEL0D00600)
KAF: KAFR_0E04290(KAFR0E04290)
PIC: PICST_84949(MNS1)
SPAA: SPAPADRAFT_57837(MNS1.1)
CAL: CAALFM_C103730CA(MNS1)
CTEN: CANTEDRAFT_110685(MNS1)
SLB: AWJ20_4611(MNS1)
NCR: NCU02778(gh47-1)
NTE: NEUTE1DRAFT74512(NEUTE1DRAFT_74512)
MGR: MGG_11408
SSCK: SPSK_05990
MAW: MAC_03073
MAJ: MAA_04109
CMT: CCM_08185
BFU: BCIN_01g06120(Bcmns1)
MBE: MBM_06132
ANG: ANI_1_1456164(An18g06220)
ABE: ARB_01040
TVE: TRV_02790
PTE: PTT_19626
ZTR: MYCGRDRAFT_45066(MgAMN9)
SPO: SPAC2E1P5.01c(mns1)
CNE: CNE04550
CNB: CNBE4550
TASA: A1Q1_06697
ABP: AGABI1DRAFT117691(AGABI1DRAFT_117691) AGABI1DRAFT130713(AGABI1DRAFT_130713) AGABI1DRAFT54540(AGABI1DRAFT_54540) AGABI1DRAFT70315(AGABI1DRAFT_70315)
ABV: AGABI2DRAFT176302(AGABI2DRAFT_176302) AGABI2DRAFT181939(AGABI2DRAFT_181939) AGABI2DRAFT206040(AGABI2DRAFT_206040) AGABI2DRAFT222683(AGABI2DRAFT_222683)
MRT: MRET_4039
SMIN: v1.2.009441.t1(symbB.v1.2.009441.t1) v1.2.009441.t2(symbB.v1.2.009441.t2) v1.2.025226.t1(symbB.v1.2.025226.t1) v1.2.032603.t1(symbB.v1.2.032603.t1)
FCY: FRACYDRAFT_261302(MNS2_1)
 » show all
Reference
  Authors
Gonzalez DS, Karaveg K, Vandersall-Nairn AS, Lal A, Moremen KW
  Title
Identification, expression, and characterization of a cDNA encoding human endoplasmic reticulum mannosidase I, the enzyme that catalyzes the first mannose  trimming step in mammalian Asn-linked oligosaccharide biosynthesis.
  Journal
J Biol Chem 274:21375-86 (1999)
DOI:10.1074/jbc.274.30.21375
  Sequence
[hsa:11253]
Reference
  Authors
Liebminger E, Huttner S, Vavra U, Fischl R, Schoberer J, Grass J, Blaukopf C, Seifert GJ, Altmann F, Mach L, Strasser R
  Title
Class I alpha-mannosidases are required for N-glycan processing and root development in Arabidopsis thaliana.
  Journal
Plant Cell 21:3850-67 (2009)
DOI:10.1105/tpc.109.072363
  Sequence
[ath:AT1G30000]
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