KEGG   ORTHOLOGY: K23756
Entry
K23756                      KO                                     

Name
ACSM1, LAE
Definition
medium-chain acyl-CoA ligase / lipoate-activating enzyme [EC:6.2.1.2]
Pathway
ko00650  Butanoate metabolism
ko00785  Lipoic acid metabolism
ko01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00650 Butanoate metabolism
    K23756  ACSM1, LAE; medium-chain acyl-CoA ligase / lipoate-activating enzyme
  09108 Metabolism of cofactors and vitamins
   00785 Lipoic acid metabolism
    K23756  ACSM1, LAE; medium-chain acyl-CoA ligase / lipoate-activating enzyme
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01004 Lipid biosynthesis proteins
    K23756  ACSM1, LAE; medium-chain acyl-CoA ligase / lipoate-activating enzyme
Enzymes [BR:ko01000]
 6. Ligases
  6.2  Forming carbon-sulfur bonds
   6.2.1  Acid-thiol ligases
    6.2.1.2  medium-chain acyl-CoA ligase
     K23756  ACSM1, LAE; medium-chain acyl-CoA ligase / lipoate-activating enzyme
Lipid biosynthesis proteins [BR:ko01004]
 Acyl-CoA synthetase
  Short/medium chain acyl-CoA synthetase
   K23756  ACSM1, LAE; medium-chain acyl-CoA ligase / lipoate-activating enzyme
Other DBs
RN: R01176 R07770
GO: 0047760
Genes
HSA: 116285(ACSM1)
PTR: 101058263(ACSM1)
PPS: 100972336(ACSM1)
GGO: 101153106(ACSM1)
PON: 100444065 100444423
MCC: 696498(ACSM1)
MCF: 102123380(ACSM1)
CSAB: 103229298(ACSM1)
RRO: 104682075(ACSM1)
RBB: 108513946(ACSM1)
MMU: 117147(Acsm1)
MCAL: 110297667(Acsm1)
MPAH: 110326344(Acsm1)
RNO: 361638(Acsm1)
MUN: 110547837(Acsm1)
CGE: 100767739
NGI: 103742763(Acsm1)
HGL: 101712893(Acsm1)
CCAN: 109696824(Acsm1)
OCU: 100352247(ACSM1)
TUP: 102480423(ACSM1)
AML: 100474845(ACSM1)
UMR: 103668661(ACSM1)
UAH: 113270722
ORO: 101367835(ACSM1)
ELK: 111156117
FCA: 101083474
PTG: 102954003
PPAD: 109278419
AJU: 106970530
BTA: 282576(ACSM1)
BOM: 102271152(ACSM1)
BIU: 109578603(ACSM1)
BBUB: 102400565(ACSM1)
CHX: 102182274(ACSM1)
OAS: 101120375(ACSM1)
CFR: 102504896(ACSM1)
CDK: 105091129(ACSM1)
LVE: 103089263
OOR: 101287714
DLE: 111171037
PCAD: 112064828
EAI: 106839008(ACSM1) 106841738
MYB: 102260013
MYD: 102762433
MNA: 107544731
HAI: 109386530(ACSM1)
RAY: 107516833
MJV: 108400240(ACSM1)
LAV: 100668576(ACSM1)
TMU: 101348158
MDO: 100619197
SHR: 100932766
PCW: 110193490
 » show all
Reference
  Authors
Fujiwara K, Takeuchi S, Okamura-Ikeda K, Motokawa Y.
  Title
Purification, characterization, and cDNA cloning of lipoate-activating enzyme from bovine liver.
  Journal
J Biol Chem 276:28819-23 (2001)
DOI:10.1074/jbc.M101748200
  Sequence
[bta:282576]
Reference
  Authors
Kasuya F, Tatsuki T, Ohta M, Kawai Y, Igarashi K
  Title
Purification, characterization, and mass spectrometric sequencing of a medium chain acyl-CoA synthetase from mouse liver mitochondria and comparisons with the homologues of rat and bovine.
  Journal
Protein Expr Purif 47:405-14 (2006)
DOI:10.1016/j.pep.2005.11.006
LinkDB

KEGG   ORTHOLOGY: K01896
Entry
K01896                      KO                                     

Name
ACSM
Definition
medium-chain acyl-CoA synthetase [EC:6.2.1.2]
Pathway
ko00650  Butanoate metabolism
ko01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00650 Butanoate metabolism
    K01896  ACSM; medium-chain acyl-CoA synthetase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01004 Lipid biosynthesis proteins
    K01896  ACSM; medium-chain acyl-CoA synthetase
Enzymes [BR:ko01000]
 6. Ligases
  6.2  Forming carbon-sulfur bonds
   6.2.1  Acid-thiol ligases
    6.2.1.2  medium-chain acyl-CoA ligase
     K01896  ACSM; medium-chain acyl-CoA synthetase
Lipid biosynthesis proteins [BR:ko01004]
 Acyl-CoA synthetase
  Short/medium chain acyl-CoA synthetase
   K01896  ACSM; medium-chain acyl-CoA synthetase
Other DBs
RN: R00389 R01176
GO: 0047760
Genes
HSA: 123876(ACSM2A) 142827(ACSM6) 341392(ACSM4) 348158(ACSM2B) 54988(ACSM5) 6296(ACSM3)
PTR: 107968805(ACSM5) 107973209 451813(ACSM4) 453974(ACSM2A) 467918(ACSM2B) 741543(ACSM6) 742192(ACSM3)
PPS: 100968187(ACSM6) 100984659(ACSM5) 100992481(ACSM4) 100994660(ACSM2A) 100994985(ACSM2B) 100995253(ACSM3)
GGO: 101142919(ACSM6) 101148413(ACSM5) 101149125 101149339(ACSM4) 101149481 101151788(ACSM3) 115932803
PON: 100171624(ACSM3) 100442712 100449779(ACSM6) 100452655(ACSM5) 100459933(ACSM4)
NLE: 100584025(ACSM5) 100591808(ACSM6) 100599336(ACSM3) 100601481 100604255(ACSM4)
MCC: 696124(ACSM5) 696244 696622(ACSM3) 722167(ACSM4)
MCF: 102120589(ACSM5) 102121480(ACSM2B) 102126505(ACSM3) 102142462(ACSM4)
CSAB: 103218505(ACSM4) 103229269(ACSM5) 103229287(ACSM2B) 103229351(ACSM3) 103231985(ACSM6)
RRO: 104682073(ACSM5) 104682074(ACSM2B) 104682078(ACSM3)
RBB: 108513900(ACSM5) 108513927 108514016(ACSM3)
CJC: 100385629(ACSM5) 100385986(ACSM2B) 100386695(ACSM3) 100390897(ACSM4) 100392977(ACSM6)
SBQ: 101039328(ACSM6) 101048755 101049288 101050441(ACSM3) 101050654(ACSM4)
MMU: 20216(Acsm3) 233799(Acsm2) 233801(Acsm4) 272428(Acsm5)
MCAL: 110297662(Acsm5) 110297791(Acsm2b) 110298435(Acsm4) 110298807(Acsm3)
MPAH: 110316032(Acsm3) 110323274(Acsm5) 110324507(Acsm4) 110325118(Acsm2b)
RNO: 246263(Acsm2) 24763(Acsm3) 353317(Acsm4) 361637(Acsm5)
NGI: 103742760(Acsm3) 103742762(Acsm4) 103742764(Acsm2a) 103742767(Acsm5)
HGL: 101698533(Acsm4) 101703873(Acsm3) 101711830(Acsm5) 101712192(Acsm2a)
CCAN: 109678356(Acsm3) 109696818(Acsm2b) 109696819(Acsm5) 109699471(Acsm4)
OCU: 100342192(ACSM2B) 100345414(ACSM3) 100350992(ACSM4) 100352493(ACSM5) 100354024
TUP: 102475928(ACSM4) 102478447(ACSM3) 102480846(ACSM5)
CFA: 479821 479822 608888(ACSM3) 609009(ACSM5)
AML: 100465944(ACSM3) 100466940(ACSM4) 100475101 100476094(ACSM5)
UMR: 103668660(ACSM5) 103668662
ORO: 101366672 101376361(ACSM5) 101382988(ACSM3) 101384131(ACSM4)
FCA: 101082455(ACSM3) 101083228 101092980(ACSM5)
PTG: 102954285(ACSM5) 102957684(ACSM4) 102968571(ACSM3)
PPAD: 109255539(ACSM3) 109255541 109278418(ACSM5)
AJU: 106970464 106970521(ACSM3) 106970531(ACSM5)
BTA: 100298888(ACSM5) 100299006(ACSM4) 512227(ACSM2B) 533798(ACSM3)
BOM: 102269733(ACSM3) 102270868(ACSM4) 102271620(ACSM2B) 102273415(ACSM5)
BIU: 109578487(ACSM3) 109578666(ACSM2B) 109578712(ACSM5)
CHX: 102180366(ACSM5) 102181180(ACSM2B) 102183382(ACSM4) 102185052(ACSM3)
OAS: 101112785(ACSM5) 101120131 101120794(ACSM4) 101121307(ACSM3)
SSC: 100510957(ACSM2B) 100511318(ACSM5) 100512220(ACSM3) 100512595(ACSM4)
CFR: 102504377(ACSM5) 102504633 102505166(ACSM4) 102505419(ACSM3)
CDK: 105091128(ACSM3) 105091130(ACSM2B) 105091131(ACSM5) 105091161(ACSM4)
BACU: 103017973(ACSM3) 103018256
LVE: 103073448(ACSM3) 103077137(ACSM5)
OOR: 101271827 101288721(ACSM3)
DLE: 111182281(ACSM3) 111182306
PCAD: 102985736(ACSM5) 102988009
ECB: 100068270 100068672(ACSM3) 100068752(ACSM4)
MYD: 102755299(ACSM2A) 102755589(ACSM3) 102760086(ACSM4)
HAI: 109386545 109386559(ACSM3) 109386584(ACSM2B) 109386585
DRO: 112304836 112304838(ACSM2B)
PALE: 102878400(ACSM3)
LAV: 100668288 100669418(ACSM3)
MDO: 100026263(ACSM5) 100026277(ACSM2A) 100026318 100026355(ACSM3)
SHR: 100927836(ACSM5) 100932504
GGA: 426991(ACSM4L) 426992(ACSM5) 426999(ACSM3)
CPIC: 101938767(ACSM3) 101939672 101939958 101940230(ACSM4)
XLA: 444799(acsm3.L)
XTR: 100491087(acsm3)
NPR: 108791737(ACSM3)
DRE: 100002035(acsm3)
SANH: 107660274
SGH: 107600064
CCAR: 109111417(acsm3)
IPU: 108280839(acsm3)
PHYP: 113533609
AMEX: 103031662
EEE: 113568123
SASA: 106569657
OTW: 112235672
SALP: 111956980(acsm3)
ELS: 105024576(acsm3)
SFM: 108926102(acsm3)
PKI: 111845537(acsm3)
LCM: 102348417(ACSM3)
CMK: 103188271(acsm3)
RTP: 109914823(acsm3) 109914830
APLC: 110980284
FCD: 110849507
PVM: 113806957
PCAN: 112571982
CRG: 105339855
MYI: 110441499
OBI: 106869167
LAK: 106166148
EPA: 110244766
AMIL: 114961120
HMG: 100203680
DML: Dmul_11310(acsA1)
DAL: Dalk_0007
SMAZ: LH19_18430
SWI: Swit_4371
SMIC: SmB9_03750
HMO: HM1_0898
SAY: TPY_0169(acs)
CTHM: CFE_1747
 » show all
Reference
  Authors
Vessey DA, Lau E, Kelley M, Warren RS
  Title
Isolation, sequencing, and expression of a cDNA for the HXM-A form of xenobiotic/medium-chain fatty acid:CoA ligase from human liver mitochondria.
  Journal
J Biochem Mol Toxicol 17:1-6 (2003)
DOI:10.1002/jbt.10056
  Sequence
[hsa:348158]
Reference
  Authors
Oka Y, Kobayakawa K, Nishizumi H, Miyamichi K, Hirose S, Tsuboi A, Sakano H
  Title
O-MACS, a novel member of the medium-chain acyl-CoA synthetase family, specifically expressed in the olfactory epithelium in a zone-specific manner.
  Journal
Eur J Biochem 270:1995-2004 (2003)
DOI:10.1046/j.1432-1033.2003.03571.x
  Sequence
[rno:353317]
Reference
  Authors
Kasuya F, Tatsuki T, Ohta M, Kawai Y, Igarashi K
  Title
Purification, characterization, and mass spectrometric sequencing of a medium chain acyl-CoA synthetase from mouse liver mitochondria and comparisons with the homologues of rat and bovine.
  Journal
Protein Expr Purif 47:405-14 (2006)
DOI:10.1016/j.pep.2005.11.006
LinkDB

KEGG   ORTHOLOGY: K01913
Entry
K01913                      KO                                     

Name
AAE7, ACN1
Definition
acetate/butyrate---CoA ligase [EC:6.2.1.1 6.2.1.2]
Pathway
ko00010  Glycolysis / Gluconeogenesis
ko00620  Pyruvate metabolism
ko00630  Glyoxylate and dicarboxylate metabolism
ko00650  Butanoate metabolism
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko01120  Microbial metabolism in diverse environments
ko01200  Carbon metabolism
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00010 Glycolysis / Gluconeogenesis
    K01913  AAE7, ACN1; acetate/butyrate---CoA ligase
   00620 Pyruvate metabolism
    K01913  AAE7, ACN1; acetate/butyrate---CoA ligase
   00630 Glyoxylate and dicarboxylate metabolism
    K01913  AAE7, ACN1; acetate/butyrate---CoA ligase
   00650 Butanoate metabolism
    K01913  AAE7, ACN1; acetate/butyrate---CoA ligase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01004 Lipid biosynthesis proteins
    K01913  AAE7, ACN1; acetate/butyrate---CoA ligase
Enzymes [BR:ko01000]
 6. Ligases
  6.2  Forming carbon-sulfur bonds
   6.2.1  Acid-thiol ligases
    6.2.1.1  acetate---CoA ligase
     K01913  AAE7, ACN1; acetate/butyrate---CoA ligase
    6.2.1.2  medium-chain acyl-CoA ligase
     K01913  AAE7, ACN1; acetate/butyrate---CoA ligase
Lipid biosynthesis proteins [BR:ko01004]
 Acyl-CoA synthetase
  Short/medium chain acyl-CoA synthetase
   K01913  AAE7, ACN1; acetate/butyrate---CoA ligase
Other DBs
RN: R00235 R00236 R00316 R01176
GO: 0003987 0047760
Genes
ATH: AT3G16910(AAE7)
ALY: 9319100
CRB: 17893002
CSAT: 104746027 104765534
EUS: EUTSA_v10020385mg
BRP: 103869727
BNA: 106401277 106452074
BOE: 106295493
RSZ: 108834635
THJ: 104802600 104820274 104820275
CPAP: 110813640
TCC: 18603611
VAR: 108347898
CCAJ: 109811435
CAM: 101508595
LJA: Lj4g3v2269810.1(Lj4g3v2269810.1) Lj4g3v2270890.1(Lj4g3v2270890.1) Lj6g3v1549210.1(Lj6g3v1549210.1)
ADU: 107463059
AIP: 107639048
FVE: 101314929
RCN: 112197158
PPER: 18789170
PMUM: 103323121
PAVI: 110763740
ZJU: 107433245
CSV: 101209903
CMO: 103483883
MCHA: 111009333
POP: 7471118
PEU: 105122780
JRE: 108982505
QSU: 112007287
INI: 109176096
OEU: 111393404
LSV: 111915365
CCAV: 112519787
BVG: 104888403
SOE: 110774740
DOSA: Os03t0305000-01(Os03g0305000) Os03t0305100-01(Os03g0305100)
ATS: 109737755(LOC109737755) 109737766(LOC109737766) 109767198(LOC109767198)
ZMA: 100191849 100281089(IDP708)
DCT: 110115861
PEQ: 110030858
AOF: 109848028
ATR: 18445085
PPP: 112286775
 » show all
Reference
  Authors
Shockey JM, Fulda MS, Browse J
  Title
Arabidopsis contains a large superfamily of acyl-activating enzymes. Phylogenetic and biochemical analysis reveals a new class of acyl-coenzyme a synthetases.
  Journal
Plant Physiol 132:1065-76 (2003)
DOI:10.1104/pp.103.020552
  Sequence
[ath:AT3G16910]
Reference
  Authors
Allen E, Moing A, Wattis JA, Larson T, Maucourt M, Graham IA, Rolin D, Hooks MA
  Title
Evidence that ACN1 (acetate non-utilizing 1) prevents carbon leakage from peroxisomes during lipid mobilization in Arabidopsis seedlings.
  Journal
Biochem J 437:505-13 (2011)
DOI:10.1042/BJ20101764
  Sequence
[ath:AT3G16910]
LinkDB

KEGG   ENZYME: 6.2.1.2
Entry
EC 6.2.1.2                  Enzyme                                 

Name
medium-chain acyl-CoA ligase;
fadK (gene name);
lvaE (gene name);
butyryl-CoA synthetase;
fatty acid thiokinase (medium chain);
acyl-activating enzyme;
fatty acid elongase;
fatty acid activating enzyme;
fatty acyl coenzyme A synthetase;
butyrate---CoA ligase;
butyryl-coenzyme A synthetase;
L-(+)-3-hydroxybutyryl CoA ligase;
short-chain acyl-CoA synthetase;
medium-chain acyl-CoA synthetase;
butanoate:CoA ligase (AMP-forming)
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
Sysname
medium-chain fatty acid:CoA ligase (AMP-forming)
Reaction(IUBMB)
ATP + a medium-chain fatty acid + CoA = AMP + diphosphate + a medium-chain acyl-CoA [RN:R00389]
Reaction(KEGG)
R00389 > R01176
Substrate
ATP [CPD:C00002];
medium-chain fatty acid [CPD:C21925];
CoA [CPD:C00010]
Product
AMP [CPD:C00020];
diphosphate [CPD:C00013];
medium-chain acyl-CoA [CPD:C21926]
Comment
Acts on fatty acids from C4 to C11 and on the corresponding 3-hydroxy and 2,3- or 3,4-unsaturated acids. The enzyme from the bacterium Pseudomonas putida also acts on 4-oxo and 4-hydroxy derivatives.
History
EC 6.2.1.2 created 1961, modified 2011, modified 2018
Pathway
ec00650  Butanoate metabolism
ec01100  Metabolic pathways
Orthology
K01896  medium-chain acyl-CoA synthetase
K01913  acetate/butyrate---CoA ligase
K23617  medium-chain acyl-CoA ligase, mitochondrial
K23618  acyl-activating enzyme 11/12
K23756  medium-chain acyl-CoA ligase / lipoate-activating enzyme
Genes
HSA: 116285(ACSM1) 123876(ACSM2A) 142827(ACSM6) 341392(ACSM4) 348158(ACSM2B) 54988(ACSM5) 6296(ACSM3) 80221(ACSF2)
PTR: 101058263(ACSM1) 107968805(ACSM5) 107973209 451813(ACSM4) 453974(ACSM2A) 455121(ACSF2) 467918(ACSM2B) 741543(ACSM6) 742192(ACSM3)
PPS: 100968187(ACSM6) 100972336(ACSM1) 100984659(ACSM5) 100986228(ACSF2) 100992481(ACSM4) 100994660(ACSM2A) 100994985(ACSM2B) 100995253(ACSM3)
GGO: 101142919(ACSM6) 101148413(ACSM5) 101149125 101149339(ACSM4) 101149481 101151788(ACSM3) 101151901(ACSF2) 101153106(ACSM1) 115932803
PON: 100171624(ACSM3) 100172872(ACSF2) 100442712 100444065 100444423 100449779(ACSM6) 100452655(ACSM5) 100459933(ACSM4)
NLE: 100583035(ACSF2) 100584025(ACSM5) 100591808(ACSM6) 100599336(ACSM3) 100601481 100604255(ACSM4) 101178788 115833719 115833922
MCC: 696124(ACSM5) 696244 696498(ACSM1) 696622(ACSM3) 702474(ACSF2) 722167(ACSM4)
MCF: 101864763(ACSF2) 102120589(ACSM5) 102121480(ACSM2B) 102123380(ACSM1) 102126505(ACSM3) 102142462(ACSM4)
CSAB: 103218505(ACSM4) 103229269(ACSM5) 103229287(ACSM2B) 103229298(ACSM1) 103229351(ACSM3) 103231985(ACSM6) 103242934(ACSF2)
RRO: 104680277(ACSF2) 104682073(ACSM5) 104682074(ACSM2B) 104682075(ACSM1) 104682078(ACSM3)
RBB: 108513900(ACSM5) 108513927 108513946(ACSM1) 108514016(ACSM3) 108516427(ACSF2)
CJC: 100385335(ACSF2) 100385629(ACSM5) 100385986(ACSM2B) 100386695(ACSM3) 100390897(ACSM4) 100392977(ACSM6)
SBQ: 101039328(ACSM6) 101048755 101049288 101050441(ACSM3) 101050654(ACSM4) 101054189(ACSF2)
MMU: 117147(Acsm1) 20216(Acsm3) 233799(Acsm2) 233801(Acsm4) 264895(Acsf2) 272428(Acsm5)
MCAL: 110297662(Acsm5) 110297667(Acsm1) 110297791(Acsm2b) 110298435(Acsm4) 110298807(Acsm3) 110304550(Acsf2)
MPAH: 110316032(Acsm3) 110323274(Acsm5) 110324507(Acsm4) 110325118(Acsm2b) 110326344(Acsm1) 110331605(Acsf2)
RNO: 246263(Acsm2) 24763(Acsm3) 353317(Acsm4) 361637(Acsm5) 361638(Acsm1) 619561(Acsf2)
NGI: 103738389(Acsf2) 103742760(Acsm3) 103742762(Acsm4) 103742763(Acsm1) 103742764(Acsm2a) 103742767(Acsm5)
HGL: 101698533(Acsm4) 101703873(Acsm3) 101706188(Acsf2) 101711830(Acsm5) 101712192(Acsm2a) 101712893(Acsm1)
CCAN: 109678356(Acsm3) 109681504(Acsf2) 109696818(Acsm2b) 109696819(Acsm5) 109696824(Acsm1) 109699471(Acsm4)
OCU: 100340861(ACSF2) 100342192(ACSM2B) 100345414(ACSM3) 100350992(ACSM4) 100352247(ACSM1) 100352493(ACSM5) 100354024
TUP: 102472841(ACSF2) 102475928(ACSM4) 102478447(ACSM3) 102480423(ACSM1) 102480846(ACSM5)
CFA: 479821 479822 480551(ACSF2) 608888(ACSM3) 609009(ACSM5)
VVP: 112917860(ACSF2) 112923250 112923378(ACSM5) 112923379 112923386(ACSM3)
AML: 100465944(ACSM3) 100466940(ACSM4) 100474727(ACSF2) 100474845(ACSM1) 100475101 100476094(ACSM5)
UMR: 103660404(ACSF2) 103668660(ACSM5) 103668661(ACSM1) 103668662
ORO: 101366672 101367835(ACSM1) 101370381(ACSF2) 101376361(ACSM5) 101382988(ACSM3) 101384131(ACSM4)
FCA: 101082455(ACSM3) 101083228 101083474 101090661(ACSF2) 101092980(ACSM5)
PTG: 102954003 102954285(ACSM5) 102957684(ACSM4) 102965614(ACSF2) 102968571(ACSM3)
PPAD: 109247289(ACSF2) 109255539(ACSM3) 109255541 109278418(ACSM5) 109278419
AJU: 106970464 106970521(ACSM3) 106970530 106970531(ACSM5) 106985171(ACSF2)
BTA: 100298888(ACSM5) 100299006(ACSM4) 282576(ACSM1) 512227(ACSM2B) 533798(ACSM3) 768237(ACSF2)
BOM: 102269733(ACSM3) 102270868(ACSM4) 102271152(ACSM1) 102271620(ACSM2B) 102273415(ACSM5) 102286919(ACSF2)
BIU: 109574170(ACSF2) 109578487(ACSM3) 109578603(ACSM1) 109578666(ACSM2B) 109578712(ACSM5)
BBUB: 102394278(ACSF2) 102400565(ACSM1) 102403896(ACSM3) 102412341 102413115
CHX: 102180366(ACSM5) 102181180(ACSM2B) 102182065(ACSF2) 102182274(ACSM1) 102183382(ACSM4) 102185052(ACSM3)
OAS: 101105582(ACSF2) 101112785(ACSM5) 101120131 101120375(ACSM1) 101120794(ACSM4) 101121307(ACSM3)
SSC: 100510957(ACSM2B) 100511318(ACSM5) 100512220(ACSM3) 100512595(ACSM4) 100512859(ACSF2)
CFR: 102504377(ACSM5) 102504633 102504896(ACSM1) 102505166(ACSM4) 102505419(ACSM3) 102521532(ACSF2)
CDK: 105091128(ACSM3) 105091129(ACSM1) 105091130(ACSM2B) 105091131(ACSM5) 105091161(ACSM4) 105097727(ACSF2)
LVE: 103069868(ACSF2) 103073448(ACSM3) 103077137(ACSM5) 103089263
PCAD: 102985736(ACSM5) 102988009 102995241(ACSF2) 112064828
MYD: 102755299(ACSM2A) 102755589(ACSM3) 102760086(ACSM4) 102762433 102773394(ACSF2)
HAI: 109380753(ACSF2) 109386530(ACSM1) 109386545 109386559(ACSM3) 109386584(ACSM2B) 109386585
DRO: 112304836 112304838(ACSM2B) 112316241(ACSF2)
PALE: 102878400(ACSM3) 102887888(ACSF2)
LAV: 100668288 100668576(ACSM1) 100669114(ACSF2) 100669418(ACSM3)
GGA: 422102(ACSF2) 426991(ACSM4L) 426992(ACSM5) 426999(ACSM3)
CPIC: 101938767(ACSM3) 101939672 101939958 101940230(ACSM4) 101946772(ACSF2)
XLA: 108701096(acsf2.L) 108702792(acsf2.S) 444799(acsm3.L)
XTR: 100491087(acsm3) 100497121(acsf2)
NPR: 108791737(ACSM3) 108796400(ACSF2)
DRE: 100002035(acsm3) 751707(acsf2)
CCAR: 109099152 109099931(acsf2) 109111417(acsm3)
IPU: 108258929 108273869(acsf2) 108280839(acsm3)
AMEX: 103031662 103037666(acsf2)
EEE: 113568123 113579428(acsf2)
NCC: 104944427 104960330(acsf2)
MZE: 101484291(acsf2) 101486716
OLA: 101165265(acsf2)
XMA: 102237186
PRET: 103468809(acsf2) 103481746
ALIM: 106529911(acsf2) 106535991
LCF: 108892016
HCQ: 109518556(acsf2) 109524735
SALP: 111956980(acsm3) 111977493(acsf2)
ELS: 105006992(acsf2) 105024576(acsm3)
SFM: 108926102(acsm3) 108935721(acsf2)
PKI: 111845537(acsm3) 111849153 111849182(acsf2)
LCM: 102348417(ACSM3) 102361353(ACSF2)
CMK: 103175647(acsf2) 103188271(acsm3)
RTP: 109914823(acsm3) 109914830 109930172(acsf2)
CIN: 100181179
DME: Dmel_CG12512(CG12512)
DSE: 6613476
DSI: Dsimw501_GD22652(Dsim_GD22652)
DAN: 6498321
DPE: 6593305
DMN: 108162311
DWI: 6642228
DAZ: 108610068
DNV: 115562762
DHE: 111599074
DVI: 6628125
MDE: 101893361
AME: 552475(ACSF2)
BIM: 100747755
BTER: 100648190
CCAL: 108623646
OBB: 114872080
SOC: 105205760
MPHA: 105841057
AEC: 105150500
ACEP: 105625916
PBAR: 105422241
VEM: 105568201
HST: 105188587
DQU: 106744856
LHU: 105671936
PGC: 109857104
OBO: 105274909
PCF: 106786684
NVI: 100122351
CSOL: 105364123
MDL: 103575983
TCA: 662861
ATD: 109593924
NVL: 108566415
BMOR: 101742019
BMAN: 114250555
PRAP: 111002740
HAW: 110384428
TNL: 113497778
CLEC: 106664881
CBR: CBG18597(Cbr-acs-2) CBG18959
BMY: Bm1_29700
TSP: Tsp_12645
ATH: AT1G65890(AAE12) AT1G66120(AAE11) AT3G16910(AAE7)
LJA: Lj0g3v0112059.1(Lj0g3v0112059.1) Lj0g3v0188849.1(Lj0g3v0188849.1) Lj4g3v2269810.1(Lj4g3v2269810.1) Lj4g3v2270890.1(Lj4g3v2270890.1) Lj6g3v0378000.1(Lj6g3v0378000.1) Lj6g3v1549210.1(Lj6g3v1549210.1)
MCHA: 111009333
DOSA: Os03t0130100-01(Os03g0130100) Os03t0305000-01(Os03g0305000) Os03t0305100-01(Os03g0305100) Os09t0555800-00(Os09g0555800)
ATS: 109737755(LOC109737755) 109737766(LOC109737766) 109750389(LOC109750389) 109759498(LOC109759498) 109759510(LOC109759510) 109759513(LOC109759513) 109761099(LOC109761099) 109767198(LOC109767198) 109774603(LOC109774603)
PPP: 112286775
CMT: CCM_05307
DML: Dmul_11310(acsA1)
DAL: Dalk_0007
DALK: DSCA_36750
SMAZ: LH19_18430
SWI: Swit_4371
SMIC: SmB9_03750
HMO: HM1_0898
SAY: TPY_0169(acs)
CTHM: CFE_1747
 » show all
Reference
1  [PMID:13084616]
  Authors
MAHLER HR, WAKIL SJ, BOCK RM.
  Title
Studies on fatty acid oxidation. I. Enzymatic activation of fatty acids.
  Journal
J Biol Chem 204:453-68 (1953)
Reference
2  [PMID:14285249]
  Authors
MASSARO EJ, LENNARZ WJ.
  Title
THE PARTIAL PURIFICATION AND CHARACTERIZATION OF A BACTERIAL FATTY ACYL COENZYME A SYNTHETASE.
  Journal
Biochemistry 4:85-90 (1965)
DOI:10.1021/bi00877a015
Reference
3  [PMID:14253428]
  Authors
WEBSTER LT Jr, GEROWIN LD, RAKITA L.
  Title
PURIFICATION AND CHARACTERISTICS OF A BUTYRYL COENZYME A SYNTHETASE FROM BOVINE HEART MITOCHONDRIA.
  Journal
J Biol Chem 240:29-33 (1965)
Reference
4  [PMID:15213221]
  Authors
Morgan-Kiss RM, Cronan JE
  Title
The Escherichia coli fadK (ydiD) gene encodes an anerobically regulated short chain acyl-CoA synthetase.
  Journal
J Biol Chem 279:37324-33 (2004)
DOI:10.1074/jbc.M405233200
Reference
5  [PMID:28947739]
  Authors
Rand JM, Pisithkul T, Clark RL, Thiede JM, Mehrer CR, Agnew DE, Campbell CE, Markley AL, Price MN, Ray J, Wetmore KM, Suh Y, Arkin AP, Deutschbauer AM, Amador-Noguez D, Pfleger BF
  Title
A metabolic pathway for catabolizing levulinic acid in bacteria.
  Journal
Nat Microbiol 2:1624-1634 (2017)
DOI:10.1038/s41564-017-0028-z
Other DBs
ExplorEnz - The Enzyme Database: 6.2.1.2
IUBMB Enzyme Nomenclature: 6.2.1.2
ExPASy - ENZYME nomenclature database: 6.2.1.2
BRENDA, the Enzyme Database: 6.2.1.2
CAS: 9080-51-7
LinkDB

KEGG   REACTION: R01176
Entry
R01176                      Reaction                               

Name
Butanoate:CoA ligase (AMP-forming)
Definition
ATP + Butanoic acid + CoA <=> AMP + Diphosphate + Butanoyl-CoA
Equation
Reaction class
RC00004  C00010_C00136
RC00014  C00136_C00246
Enzyme
Pathway
rn00650  Butanoate metabolism
rn01100  Metabolic pathways
Orthology
K01896  medium-chain acyl-CoA synthetase [EC:6.2.1.2]
K01913  acetate/butyrate---CoA ligase [EC:6.2.1.1 6.2.1.2]
K23756  medium-chain acyl-CoA ligase / lipoate-activating enzyme [EC:6.2.1.2]
LinkDB

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