KEGG   ORTHOLOGY: K24287
Entry
K24287                      KO                                     

Name
lmbB2
Definition
L-tyrosine peroxygenase [EC:1.11.2.6]
Pathway
ko00350  Tyrosine metabolism
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00350 Tyrosine metabolism
    K24287  lmbB2; L-tyrosine peroxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.11  Acting on a peroxide as acceptor
   1.11.2  Peroxygenases
    1.11.2.6  L-tyrosine peroxygenase
     K24287  lmbB2; L-tyrosine peroxygenase
Other DBs
RN: R12611
Genes
NBR: O3I_021195
NOZ: DMB37_35910
NAH: F5544_09850
SHY: SHJG_8632
SHO: SHJGH_8392
SLS: SLINC_0235
SNZ: DC008_26540
KAB: B7C62_33400
SACG: FDZ84_04225
AMD: AMED_5527
AMN: RAM_28170
AMM: AMES_5460
AMZ: B737_5460
AOI: AORI_5444
AMYY: YIM_25150
AORI: SD37_10250
KAL: KALB_5794
 » show all
Reference
PMID:8577249
  Authors
Peschke U, Schmidt H, Zhang HZ, Piepersberg W
  Title
Molecular characterization of the lincomycin-production gene cluster of Streptomyces lincolnensis 78-11.
  Journal
Mol Microbiol 16:1137-56 (1995)
DOI:10.1111/j.1365-2958.1995.tb02338.x
  Sequence
Reference
PMID:9531633
  Authors
Neusser D, Schmidt H, Spizek J, Novotna J, Peschke U, Kaschabeck S, Tichy P, Piepersberg W
  Title
The genes lmbB1 and lmbB2 of Streptomyces lincolnensis encode enzymes involved in the conversion of L-tyrosine to propylproline during the biosynthesis of the antibiotic lincomycin A.
  Journal
Arch Microbiol 169:322-32 (1998)
DOI:10.1007/s002030050578
LinkDB

KEGG   ENZYME: 1.11.2.6
Entry
EC 1.11.2.6                 Enzyme                                 

Name
L-tyrosine peroxygenase
Class
Oxidoreductases;
Acting on a peroxide as acceptor;
Peroxygenases
Sysname
L-tyrosine:hydrogen-peroxide oxidoreductase (L-dopa-forming)
Reaction(IUBMB)
L-tyrosine + H2O2 = L-dopa + H2O [RN:R12611]
Reaction(KEGG)
R12611
Substrate
L-tyrosine [CPD:C00082];
H2O2 [CPD:C00027]
Product
L-dopa [CPD:C00355];
H2O [CPD:C00001]
Comment
The enzyme from the bacterium Streptomyces lincolnensis participates in the biosynthesis of the antibiotic lincomycin A, while that from Streptomyces refuineus is involved in anthramycin biosynthesis. The enzyme, which contains a heme b cofactor, is rapidly inactivated in the presence of hydrogen peroxide, but the presence of L-tyrosine protects it. cf. EC 1.11.2.5, 3-methyl-L-tyrosine peroxygenase.
History
EC 1.11.2.6 created 2020
Pathway
ec00350  Tyrosine metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K24287  L-tyrosine peroxygenase
Genes
NBR: O3I_021195
NOZ: DMB37_35910
NAH: F5544_09850
SHY: SHJG_8632
SHO: SHJGH_8392
SLS: SLINC_0235
SNZ: DC008_26540
KAB: B7C62_33400
SACG: FDZ84_04225
AMD: AMED_5527
AMN: RAM_28170
AMM: AMES_5460
AMZ: B737_5460
AOI: AORI_5444
AMYY: YIM_25150
AORI: SD37_10250
KAL: KALB_5794
 » show all
Reference
1  [PMID:9531633]
  Authors
Neusser D, Schmidt H, Spizek J, Novotna J, Peschke U, Kaschabeck S, Tichy P, Piepersberg W
  Title
The genes lmbB1 and lmbB2 of Streptomyces lincolnensis encode enzymes involved in the conversion of L-tyrosine to propylproline during the biosynthesis of the antibiotic lincomycin A.
  Journal
Arch Microbiol 169:322-32 (1998)
DOI:10.1007/s002030050578
Reference
2  [PMID:21919439]
  Authors
Connor KL, Colabroy KL, Gerratana B
  Title
A heme peroxidase with a functional role as an L-tyrosine hydroxylase in the biosynthesis of anthramycin.
  Journal
Biochemistry 50:8926-36 (2011)
DOI:10.1021/bi201148a
Other DBs
ExplorEnz - The Enzyme Database: 1.11.2.6
IUBMB Enzyme Nomenclature: 1.11.2.6
ExPASy - ENZYME nomenclature database: 1.11.2.6
BRENDA, the Enzyme Database: 1.11.2.6
LinkDB

KEGG   REACTION: R12611
Entry
R12611                      Reaction                               

Name
L-tyrosine:hydrogen-peroxide oxidoreductase (L-dopa-forming)
Definition
L-Tyrosine + Hydrogen peroxide <=> 3,4-Dihydroxy-L-phenylalanine + H2O
Equation
Reaction class
RC00046  C00082_C00355
Enzyme
Pathway
rn00350  Tyrosine metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K24287  L-tyrosine peroxygenase [EC:1.11.2.6]
LinkDB

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