KEGG   MODULE: M00036
Entry
M00036            Pathway   Module                                 

Name
Leucine degradation, leucine => acetoacetate + acetyl-CoA
Definition
K00826 ((K00166+K00167,K11381)+K09699+K00382) (K00253,K00249) (K01968+K01969) (K05607,K13766) K01640
Diagram
M00036

Orthology
K00826  
branched-chain amino acid aminotransferase [EC:2.6.1.42] [RN:R01090]
2-oxoisovalerate dehydrogenase [EC:1.2.4.4] [RN:R07601 R07602]
K09699  
2-oxoisovalerate dehydrogenase [EC:2.3.1.168] [RN:R04097]
K00382  
dihydrolipoamide dehydrogenase [EC:1.8.1.4] [RN:R07618]
K00253  
isovaleryl-CoA dehydrogenase [EC:1.3.99.10] [RN:R04095]
K00249  
acyl-CoA dehydrogenase [EC:1.3.8.7] [RN:R04095]
3-methylcrotonyl-CoA carboxylase [EC:6.4.1.4] [RN:R04138]
methylglutaconyl-CoA hydratase [EC:4.2.1.18] [RN:R02085]
K01640  
hydroxymethylglutaryl-CoA lyase [EC:4.1.3.4] [RN:R01360]
Class
Pathway modules; Amino acid metabolism; Branched-chain amino acid metabolism
Pathway
map00280  Valine, leucine and isoleucine degradation
map01100  Metabolic pathways
Reaction
Compound
C00123  L-Leucine
C00233  4-Methyl-2-oxopentanoate
C15972  Enzyme N6-(lipoyl)lysine
C15975  [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(3-methylbutanoyl)dihydrolipoyllysine
C02939  3-Methylbutanoyl-CoA
C15973  Enzyme N6-(dihydrolipoyl)lysine
C03069  3-Methylcrotonyl-CoA
C03231  3-Methylglutaconyl-CoA
C00356  (S)-3-Hydroxy-3-methylglutaryl-CoA
C00164  Acetoacetate
LinkDB

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