KEGG   MODULE: M00356
Entry
M00356            Pathway   Module                                 

Name
Methanogenesis, methanol => methane
Definition
K14080+K04480+K14081 K00399+K00401+K00402 (K22480+K22481+K22482,K03388+K03389+K03390,K08264+K08265,K03388+K03389+K03390+K14127+(K14126+K14128,K22516+K00125))
Diagram
M00356

Orthology
K14080  
[methyl-Co(III) methanol-specific corrinoid protein]:coenzyme M methyltransferase [EC:2.1.1.246] [RN:R09098]
K04480  
methanol---5-hydroxybenzimidazolylcobamide Co-methyltransferase [EC:2.1.1.90] [RN:R09098]
K14081  
methanol corrinoid protein [RN:R09098]
methyl-coenzyme M reductase [EC:2.8.4.1] [RN:R04541]
heterodisulfide reductase 1 [EC:1.8.7.3] [RN:R11931]
heterodisulfide reductase 2 [EC:1.8.7.3 1.8.98.4 1.8.98.5 1.8.98.6] [RN:R11928 R11931 R11943 R11944]
heterodisulfide reductase [EC:1.8.98.1] [RN:R04540]
F420-non-reducing hydrogenase [EC:1.8.98.5] [RN:R11943]
K14127  
F420-non-reducing hydrogenase iron-sulfur subunit [EC:1.8.98.5 1.8.98.6] [RN:R11943 R11944]
formate dehydrogenase (coenzyme F420) [EC:1.8.98.6] [RN:R11944]
Class
Pathway modules; Energy metabolism; Methane metabolism
Pathway
map00680  Methane metabolism
map01200  Carbon metabolism
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
Reaction
Compound
C00132  Methanol
C03920  2-(Methylthio)ethanesulfonate
C04628  Coenzyme B
C01438  Methane
C04832  Coenzyme M 7-mercaptoheptanoylthreonine-phosphate heterodisulfide
Comment
Organism group: methanogenic archaea
Reference
  Authors
Liu Y, Whitman WB
  Title
Metabolic, phylogenetic, and ecological diversity of the methanogenic archaea.
  Journal
Ann N Y Acad Sci 1125:171-89 (2008)
DOI:10.1196/annals.1419.019
Reference
  Authors
Sauer K, Thauer RK
  Title
Methanol:coenzyme M methyltransferase from Methanosarcina barkeri -- substitution of the corrinoid harbouring subunit MtaC by free cob(I)alamin.
  Journal
Eur J Biochem 261:674-81 (1999)
DOI:10.1046/j.1432-1327.1999.00355.x
Reference
  Authors
Pritchett MA, Metcalf WW
  Title
Genetic, physiological and biochemical characterization of multiple methanol methyltransferase isozymes in Methanosarcina acetivorans C2A.
  Journal
Mol Microbiol 56:1183-94 (2005)
DOI:10.1111/j.1365-2958.2005.04616.x
Reference
  Authors
Rother M, Krzycki JA
  Title
Selenocysteine, pyrrolysine, and the unique energy metabolism of methanogenic archaea.
  Journal
Archaea 2010:453642 (2010)
DOI:10.1155/2010/453642
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