KEGG   MODULE: M00373
Entry
M00373            Pathway   Module                                 

Name
Ethylmalonyl pathway
Definition
K00626 K00023 K17865 K14446 K14447 K14448 K14449 K08691 K14451
K01965+K01966 K05606 K01847
Diagram
M00373

Orthology
K00626  
acetyl-CoA C-acetyltransferase [EC:2.3.1.9] [RN:R00238]
K00023  
acetoacetyl-CoA reductase [EC:1.1.1.36] [RN:R01977]
K17865  
3-hydroxybutyryl-CoA dehydratase [EC:4.2.1.55] [RN:R03027]
K14446  
crotonyl-CoA carboxylase/reductase [EC:1.3.1.85] [RN:R09291]
K14447  
ethylmalonyl-CoA mutase [EC:5.4.99.63] [RN:R09292]
K14448  
(2S)-methylsuccinyl-CoA dehydrogenase [EC:1.3.8.12] [RN:R09293]
K14449  
2-methylfumaryl-CoA hydratase [EC:4.2.1.148] [RN:R05076]
K08691  
malyl-CoA lyase [EC:4.1.3.24] [RN:R00934 R00473]
K14451  
(3S)-malyl-CoA thioesterase [RN:R10612]
propionyl-CoA carboxylase [EC:6.4.1.3] [RN:R01859]
K05606  
methylmalonyl-CoA/ethylmalonyl-CoA epimerase [EC:5.1.99.1] [RN:R02765 R09979]
K01847  
methylmalonyl-CoA mutase [EC:5.4.99.2] [RN:R00833]
Class
Pathway modules; Carbohydrate metabolism; Other carbohydrate metabolism
Pathway
map00630  Glyoxylate and dicarboxylate metabolism
map01200  Carbon metabolism
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
Reaction
Compound
C00024  Acetyl-CoA
C00332  Acetoacetyl-CoA
C03561  (R)-3-Hydroxybutanoyl-CoA
C00877  Crotonoyl-CoA
C18026  (2S)-Ethylmalonyl-CoA
C20238  (2R)-Ethylmalonyl-CoA
C18324  (2S)-Methylsuccinyl-CoA
C06028  2-Methylfumaryl-CoA
C06027  L-erythro-3-Methylmalyl-CoA
C00100  Propanoyl-CoA
C00048  Glyoxylate
C04348  L-Malyl-CoA
C00149  (S)-Malate
C00683  (S)-Methylmalonyl-CoA
C01213  (R)-Methylmalonyl-CoA
C00091  Succinyl-CoA
Reference
  Authors
Zarzycki J, Schlichting A, Strychalsky N, Muller M, Alber BE, Fuchs G
  Title
Mesaconyl-coenzyme A hydratase, a new enzyme of two central carbon metabolic pathways in bacteria.
  Journal
J Bacteriol 190:1366-74 (2008)
DOI:10.1128/JB.01621-07
Reference
  Authors
Erb TJ, Retey J, Fuchs G, Alber BE
  Title
Ethylmalonyl-CoA mutase from Rhodobacter sphaeroides defines a new subclade of coenzyme B12-dependent acyl-CoA mutases.
  Journal
J Biol Chem 283:32283-93 (2008)
DOI:10.1074/jbc.M805527200
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