KEGG   MODULE: M00378
Entry
M00378            Pathway   Module                                 
Name
F420 biosynthesis, archaea
Definition
K11780+K11781
K14941
K11212 K12234
Diagram
M00378

Orthology
K11781  
5-amino-6-(D-ribitylamino)uracil---L-tyrosine 4-hydroxyphenyl transferase [EC:2.5.1.147] [RN:R12161]
K11780  
7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase [EC:4.3.1.32] [RN:R12162]
K14941  
2-phospho-L-lactate guanylyltransferase [EC:2.7.7.68] [RN:R09397]
K11212  
LPPG:FO 2-phospho-L-lactate transferase [EC:2.7.8.28] [RN:R09398]
K12234  
coenzyme F420-0:L-glutamate ligase / coenzyme F420-1:gamma-L-glutamate ligase [EC:6.3.2.31 6.3.2.34] [RN:R09399 R09400]
Class
Pathway modules; Energy metabolism; Methane metabolism
Pathway
map00680  Methane metabolism
map01240  Biosynthesis of cofactors
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
Reaction
Compound
C04732  5-Amino-6-(1-D-ribitylamino)uracil
C21971  5-Amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil
C19154  7,8-Didemethyl-8-hydroxy-5-deazariboflavin
C19156  (2S)-2-Phospholactate
C19155  (2S)-Lactyl-2-diphospho-5'-guanosine
C19153  Coenzyme F420-0
C19152  Coenzyme F420-1
C00876  Coenzyme F420
Reference
  Authors
Graham DE, Xu H, White RH
  Title
Identification of the 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase required for coenzyme F(420) biosynthesis.
  Journal
Arch Microbiol 180:455-64 (2003)
DOI:10.1007/s00203-003-0614-8
Reference
  Authors
Grochowski LL, Xu H, White RH
  Title
Identification and characterization of the 2-phospho-L-lactate guanylyltransferase involved in coenzyme F420 biosynthesis.
  Journal
Biochemistry 47:3033-7 (2008)
DOI:10.1021/bi702475t
Reference
  Authors
Graupner M, Xu H, White RH
  Title
Characterization of the 2-phospho-L-lactate transferase enzyme involved in coenzyme F(420) biosynthesis in Methanococcus jannaschii.
  Journal
Biochemistry 41:3754-61 (2002)
DOI:10.1021/bi011937v
Reference
  Authors
Li H, Graupner M, Xu H, White RH
  Title
CofE catalyzes the addition of two glutamates to F420-0 in F420 coenzyme biosynthesis in Methanococcus jannaschii.
  Journal
Biochemistry 42:9771-8 (2003)
DOI:10.1021/bi034779b
Reference
  Authors
Li H, Xu H, Graham DE, White RH
  Title
Glutathione synthetase homologs encode alpha-L-glutamate ligases for methanogenic coenzyme F420 and tetrahydrosarcinapterin biosyntheses.
  Journal
Proc Natl Acad Sci U S A 100:9785-90 (2003)
DOI:10.1073/pnas.1733391100
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