KEGG   MODULE: M00572
Entry
M00572            Pathway   Module                                 

Name
Pimeloyl-ACP biosynthesis, BioC-BioH pathway, malonyl-ACP => pimeloyl-ACP
Definition
K02169 (K00647,K09458) K00059 K02372 K00208 (K02170,K09789,K19560,K19561)
Diagram
M00572

Orthology
K02169 malonyl-CoA O-methyltransferase [EC:2.1.1.197] [RN:R09543]  
 
3-oxoacyl-[acyl-carrier-protein] synthase [EC:2.3.1.41 2.3.1.179] [RN:R10115 R10119]
K00059  
3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100] [RN:R10116 R10120]
K02372  
3-hydroxyacyl-[acyl-carrier-protein] dehydratase [EC:4.2.1.59] [RN:R10117 R10121]
K00208  
enoyl-[acyl-carrier protein] reductase [EC:1.3.1.10] [RN:R10118 R10122]
K02170,K09789,K19560,K19561 pimelyl-[acyl-carrier protein] methyl ester esterase [EC:3.1.1.85] [RN:R09725]  
 
Class
Pathway modules; Metabolism of cofactors and vitamins; Cofactor and vitamin metabolism
Pathway
map00780  Biotin metabolism
map01240  Biosynthesis of cofactors
map01100  Metabolic pathways
Reaction
Compound
C01209  Malonyl-[acp]
C19673  Malonyl-[acp] methyl ester
C20372  3-Ketoglutaryl-[acp] methyl ester
C20373  3-Hydroxyglutaryl-[acp] methyl ester
C20374  Enoylglutaryl-[acp] methyl ester
C20375  Glutaryl-[acp] methyl ester
C20376  3-Ketopimeloyl-[acp] methyl ester
C20377  3-Hydroxypimeloyl-[acp] methyl ester
C20378  Enoylpimeloyl-[acp] methyl ester
C19846  Pimelyl-[acp] methyl ester
C19845  Pimelyl-[acp]
Reference
  Authors
Lin S, Cronan JE
  Title
Closing in on complete pathways of biotin biosynthesis.
  Journal
Mol Biosyst 7:1811-21 (2011)
DOI:10.1039/c1mb05022b
Reference
  Authors
Lin S, Cronan JE
  Title
The BioC O-methyltransferase catalyzes methyl esterification of malonyl-acyl carrier protein, an essential step in biotin synthesis.
  Journal
J Biol Chem 287:37010-20 (2012)
DOI:10.1074/jbc.M112.410290
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