KEGG   MODULE: M00740
Entry
M00740            Pathway   Module                                 

Name
Methylaspartate cycle
Definition
K01647 K01681 K00031 K00261 K19268+K01846 K04835 K19280 K14449 K19281 K19282 K00024
Diagram
M00740

Orthology
K01647  
citrate synthase [EC:2.3.3.1] [RN:R00351]
K01681  
aconitate hydratase [EC:4.2.1.3] [RN:R01325 R01900]
K00031  
isocitrate dehydrogenase [EC:1.1.1.42] [RN:R01899 R00268]
K00261  
glutamate dehydrogenase (NAD(P)+) [EC:1.4.1.3] [RN:R00248]
methylaspartate mutase epsilon subunit [EC:5.4.99.1] [RN:R00262]
K04835  
methylaspartate ammonia-lyase [EC:4.3.1.2] [RN:R03696]
K19280  
succinyl-CoA:mesaconate CoA transferase [EC:2.8.3.26] [RN:R10904]
K14449  
2-methylfumaryl-CoA hydratase [EC:4.2.1.148] [RN:R05076]
K19281  
beta-methylmalyl-CoA/(S)-malyl-CoA lyase [EC:4.1.3.24] [RN:R00934]
K19282  
bifunctional (S)-malyl-CoA lyase/thioesterase [EC:4.1.3.24 3.1.2.30] [RN:R00473 R10612]
K00024  
malate dehydrogenase [EC:1.1.1.37] [RN:R00342]
Class
Pathway modules; Carbohydrate metabolism; Other carbohydrate metabolism
Pathway
map00020  Citrate cycle (TCA cycle)
map00250  Alanine, aspartate and glutamate metabolism
map00630  Glyoxylate and dicarboxylate metabolism
map01200  Carbon metabolism
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
Reaction
Compound
C00036  Oxaloacetate
C00024  Acetyl-CoA
C00158  Citrate
C00417  cis-Aconitate
C00311  Isocitrate
C05379  Oxalosuccinate
C00026  2-Oxoglutarate
C00025  L-Glutamate
C03618  L-threo-3-Methylaspartate
C01732  Mesaconate
C06028  2-Methylfumaryl-CoA
C06027  L-erythro-3-Methylmalyl-CoA
C00048  Glyoxylate
C04348  L-Malyl-CoA
C00149  (S)-Malate
Comment
Acetyl-CoA assimilation via the methylaspartate cycle: M00740+M00741
Organism group: haloarchaea (halobacteria)
Reference
  Authors
Khomyakova M, Bukmez O, Thomas LK, Erb TJ, Berg IA
  Title
A methylaspartate cycle in haloarchaea.
  Journal
Science 331:334-7 (2011)
DOI:10.1126/science.1196544
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