KEGG   MODULE: M00763
Entry
M00763            Pathway   Module                                 

Name
Ornithine biosynthesis, mediated by LysW, glutamate => ornithine
Definition
K05826
K19412 K05828 K05829 K05830 K05831
Diagram
M00763

Orthology
K05826  
glutamate carrier protein LysW
K19412  
glutamate--LysW ligase ArgX [EC:6.3.2.-] [RN:R10929]
K05828  
LysW-L-glutamate kinase [EC:2.7.2.-] [RN:R10930]
K05829  
LysW-L-glutamyl-5-phosphate reductase [EC:1.2.1.-] [RN:R10931]
K05830  
LysW-L-ornithine aminotransferase [EC:2.6.1.-] [RN:R10932]
K05831  
LysW-L-ornithine hydrolase [EC:3.5.1.132] [RN:R10933]
Class
Pathway modules; Amino acid metabolism; Arginine and proline metabolism
Pathway
map00220  Arginine biosynthesis
map01210  2-Oxocarboxylic acid metabolism
map01230  Biosynthesis of amino acids
map01100  Metabolic pathways
Reaction
Compound
C00025  L-Glutamate
C20948  LysW-L-glutamate
C20949  LysW-L-glutamyl 5-phosphate
C20950  LysW-L-glutamate 5-semialdehyde
C20951  LysW-L-ornithine
C00077  L-Ornithine
RModule
RM002  Carboxyl to amino conversion using protective N-acetyl group (basic amino acid synthesis)
Reference
  Authors
Ouchi T, Tomita T, Horie A, Yoshida A, Takahashi K, Nishida H, Lassak K, Taka H, Mineki R, Fujimura T, Kosono S, Nishiyama C, Masui R, Kuramitsu S, Albers SV, Kuzuyama T, Nishiyama M
  Title
Lysine and arginine biosyntheses mediated by a common carrier protein in Sulfolobus.
  Journal
Nat Chem Biol 9:277-83 (2013)
DOI:10.1038/nchembio.1200
LinkDB

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