KEGG   MODULE: M00785
Entry
M00785            Pathway   Module                                 

Name
Cycloserine biosynthesis, arginine/serine => cycloserine
Definition
K19741 K19723
K19726
K19725 K19724 K19727
Diagram
M00785

Orthology
K19741  
dcsA; Nomega-hydroxy-L-arginine synthase [EC1.14.-.-] [RN:R11033]
K19723  
dcsB; Nomega-hydroxy-L-arginine amidinohydrolase [EC:3.5.3.25] [RN:R10466]
K19726  
dcsE; serine/homoserine O-acetyltransferase [EC:2.3.1.30 2.3.1.31] [RN:R00586]
K19725  
dcsD; O-ureido-L-serine/cysteine synthase [EC:2.6.99.3 2.5.1.47] [RN:R10461]
K19724  
dcsC; O-ureido-serine racemase [EC:5.1.1.19] [RN:R10488]
K19727  
dcsG; O-ureido-D-serine cyclo-ligase [EC:6.3.3.5] [RN:R10470]
Class
Pathway modules; Biosynthesis of other secondary metabolites; Biosynthesis of other antibiotics
Pathway
map00997  Biosynthesis of various secondary metabolites - part 3
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Reaction
Compound
C00065  L-Serine
C00979  O-Acetyl-L-serine
C00062  L-Arginine
C05933  N(omega)-Hydroxyarginine
C07044  Hydroxyurea
C00077  L-Ornithine
C20639  O-Ureido-L-serine
C20651  O-Ureido-D-serine
C08057  Cycloserine
Reference
  Authors
Kumagai T, Koyama Y, Oda K, Noda M, Matoba Y, Sugiyama M
  Title
Molecular cloning and heterologous expression of a biosynthetic gene cluster for the antitubercular agent D-cycloserine produced by Streptomyces lavendulae.
  Journal
Antimicrob Agents Chemother 54:1132-9 (2010)
DOI:10.1128/AAC.01226-09
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