KEGG   MODULE: M00787
Entry
M00787            Pathway   Module                                 

Name
Bacilysin biosynthesis, prephenate => bacilysin
Definition
K19546 K19547 K19550 K19549 K19548 K13037
Diagram
M00787

Orthology
K19546  
bacA; bacA; prephenate decarboxylase [EC:4.1.1.100] [RN:R10934]
K19547  
bacB; 3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate isomerase [EC:5.3.3.19] [RN:R11065]
K19550  
bacG; bacilysin biosynthesis oxidoreductase BacG [EC:1.3.1.-] [RN:R11067]
K19549  
bacF; bacilysin biosynthesis transaminase BacF [EC:2.6.1.-] [RN:R11068]
K19548  
bacC; dihydroanticapsin dehydrogenase [EC:1.1.1.385] [RN:R10917]
K13037  
bacD; L-alanine-L-anticapsin ligase [EC:6.3.2.49] [RN:R11064]
Class
Pathway modules; Biosynthesis of other secondary metabolites; Biosynthesis of other antibiotics
Pathway
map00998  Biosynthesis of various secondary metabolites - part 2
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Reaction
Compound
C00254  Prephenate
C20953  3-[(4R)-4-Hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate
C21085  3-[(1E,4R)-4-Hydroxycyclohex-2-en-1-ylidene]-2-oxopropanoate
C21086  Epoxy-3E-H2HPP
C21087  Epoxy-4S-H4HPP
C20940  L-Dihydroanticapsin
C20941  L-Anticapsin
C20942  Bacilysin
Reference
  Authors
Ozcengiz G, Ogulur I
  Title
Biochemistry, genetics and regulation of bacilysin biosynthesis and its significance more than an antibiotic.
  Journal
N Biotechnol 32:612-9 (2015)
DOI:10.1016/j.nbt.2015.01.006
Reference
  Authors
Mahlstedt SA, Walsh CT
  Title
Investigation of anticapsin biosynthesis reveals a four-enzyme pathway to tetrahydrotyrosine in Bacillus subtilis.
  Journal
Biochemistry 49:912-23 (2010)
DOI:10.1021/bi9021186
Reference
  Authors
Steinborn G, Hajirezaei MR, Hofemeister J
  Title
bac genes for recombinant bacilysin and anticapsin production in Bacillus host strains.
  Journal
Arch Microbiol 183:71-9 (2005)
DOI:10.1007/s00203-004-0743-8
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