KEGG   MODULE: M00815
Entry
M00815            Pathway   Module                                 

Name
Validamycin A biosynthesis, sedoheptulopyranose-7P => validamycin A
Definition
K19969 K20431 K20432 K20433 K20434 K20435 K20436 K20437 K20438
Diagram
M00815

Orthology
K19969  
valA; 2-epi-5-epi-valiolone synthase [EC:4.2.3.152] [RN:R10937]
K20431  
valD; 2-epi-5-epi-valiolone epimerase [EC:5.1.3.33] [RN:R11079]
K20432  
valK; 5-epi-valiolone dehydratase [EC:4.2.1.-] [RN:R11233]
K20433  
valC; C7-cyclitol kinase [EC:2.7.1.-] [RN:R11234]
K20434  
valN; cyclitol reductase [RN:R11236]
K20435  
valM; validone 7-phosphate aminotransferase [EC2.6.1.-] [RN:R11238]
K20436  
valL; validoxylamine A 7'-phosphate synthase [EC:2.4.1.-] [RN:R11497]
K20437  
vldH; validoxylamine A 7'-phosphate phosphatase [EC:3.1.3.101] [RN:R11240]
K20438  
valG; validoxylamine A glucosyltransferase [EC:2.4.1.338] [RN:R11241]
Class
Pathway modules; Biosynthesis of other secondary metabolites; Biosynthesis of other antibiotics
Pathway
map00525  Acarbose and validamycin biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Reaction
Compound
C20956  alpha-D-Sedoheptulopyranose 7-phosphate
C17691  2-epi-5-epi-Valiolone
C17694  5-epi-Valiolone
C17696  Valienone
C17697  Valienone 7-phosphate
C21218  Validone 7-phosphate
C21216  Validamine 7-phosphate
C21368  GDP-valienol
C21219  Validoxylamine A 7'-phosphate
C17700  Validoxylamine A
C12112  Validamycin A
Reference
  Authors
Bai L, Li L, Xu H, Minagawa K, Yu Y, Zhang Y, Zhou X, Floss HG, Mahmud T, Deng Z
  Title
Functional analysis of the validamycin biosynthetic gene cluster and engineered production of validoxylamine A.
  Journal
Chem Biol 13:387-97 (2006)
DOI:10.1016/j.chembiol.2006.02.002
Reference
  Authors
Singh D, Seo MJ, Kwon HJ, Rajkarnikar A, Kim KR, Kim SO, Suh JW
  Title
Genetic localization and heterologous expression of validamycin biosynthetic gene cluster isolated from Streptomyces hygroscopicus var. limoneus KCCM 11405 (IFO 12704).
  Journal
Gene 376:13-23 (2006)
DOI:10.1016/j.gene.2005.12.035
Reference
  Authors
Deng Z, Bai L
  Title
Antibiotic biosynthetic pathways and pathway engineering--a growing research field in China.
  Journal
Nat Prod Rep 23:811-27 (2006)
DOI:10.1039/b611140h
Reference
  Authors
Asamizu S, Yang J, Almabruk KH, Mahmud T
  Title
Pseudoglycosyltransferase catalyzes nonglycosidic C-N coupling in validamycin a biosynthesis.
  Journal
J Am Chem Soc 133:12124-35 (2011)
DOI:10.1021/ja203574u
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