KEGG   MODULE: M00841
Entry
M00841            Pathway   Module                                 

Name
Tetrahydrofolate biosynthesis, mediated by PTPS, GTP => THF
Definition
K01495 K22101 K13941 K11754 K13998
Diagram
M00841

Orthology
K01495  
GTP cyclohydrolase IA [EC:3.5.4.16] [RN:R00428 R05046 R05048 R04639]
K22101  
dihydroneopterin triphosphate aldolase (PTPS-III) [EC:4.1.2.60] [RN:R11719]
K13941  
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase / dihydropteroate synthase [EC:2.7.6.3 2.5.1.15] [RN:R03503 R03067 R03066]
K11754  
dihydrofolate synthase [EC:6.3.2.12] [RN:R02237]
K13998  
dihydrofolate reductase [EC:1.5.1.3] [RN:R00936 R00939]
Class
Pathway modules; Metabolism of cofactors and vitamins; Cofactor and vitamin metabolism
Pathway
map00790  Folate biosynthesis
map01240  Biosynthesis of cofactors
map01100  Metabolic pathways
Reaction
Compound
C00044  GTP
C05922  Formamidopyrimidine nucleoside triphosphate
C05923  2,5-Diaminopyrimidine nucleoside triphosphate
C06148  2,5-Diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine
C04895  7,8-Dihydroneopterin 3'-triphosphate
C01300  6-(Hydroxymethyl)-7,8-dihydropterin
C04807  6-Hydroxymethyl-7,8-dihydropterin diphosphate
C00921  Dihydropteroate
C00415  Dihydrofolate
C00101  Tetrahydrofolate
Reference
  Authors
Dittrich S, Mitchell SL, Blagborough AM, Wang Q, Wang P, Sims PF, Hyde JE
  Title
An atypical orthologue of 6-pyruvoyltetrahydropterin synthase can provide the missing link in the folate biosynthesis pathway of malaria parasites.
  Journal
Mol Microbiol 67:609-18 (2008)
DOI:10.1111/j.1365-2958.2007.06073.x
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