KEGG   MODULE: M00882
Entry
M00882            Pathway   Module                                 

Name
Lipoic acid biosynthesis, eukaryotes, octanoyl-ACP => dihydrolipoyl-H
Definition
K23735 K03644
Diagram
M00882

Orthology
K23735  
LIP2; lipoyl(octanoyl) transferase 2 [EC:2.3.1.181] [RN:R12428]
K03644  
LIP5; lipoyl synthase [EC:2.8.1.8] [RN:R12424]
Class
Pathway modules; Metabolism of cofactors and vitamins; Cofactor and vitamin metabolism
Pathway
map00785  Lipoic acid metabolism
map01240  Biosynthesis of cofactors
map01100  Metabolic pathways
Reaction
Compound
C05752  Octanoyl-[acp]
C22159  [Glycine cleavage system H]-N6-octanoyl-L-lysine
C02972  [Glycine cleavage system H]-N6-[(R)-dihydrolipoyl]-L-lysine
Reference
  Authors
Cronan JE
  Title
Assembly of Lipoic Acid on Its Cognate Enzymes: an Extraordinary and Essential Biosynthetic Pathway.
  Journal
Microbiol Mol Biol Rev 80:429-50 (2016)
DOI:10.1128/MMBR.00073-15
Reference
  Authors
Solmonson A, DeBerardinis RJ
  Title
Lipoic acid metabolism and mitochondrial redox regulation.
  Journal
J Biol Chem 293:7522-7530 (2018)
DOI:10.1074/jbc.TM117.000259
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