KEGG   MODULE: M00895
Entry
M00895            Pathway   Module                                 

Name
Thiamine biosynthesis, prokaryotes, AIR (+ DXP/glycine) => TMP/TPP
Definition
K03148+K03154 K03151
K03153 K03149 K10810
K03147 K00941 K00788 K00946
Diagram
M00895

Orthology
K03148  
thiF; sulfur carrier protein ThiS adenylyltransferase [EC:2.7.7.73] [RN:R07459]
K03154  
thiS; sulfur carrier protein
K03151  
thiI; tRNA uracil 4-sulfurtransferase [EC:2.8.1.4] [RN:R07461]
K03153  
thiO; glycine oxidase [EC:1.4.3.19] [RN:R07463]
K03149  
thiG; thiazole synthase [EC:2.8.1.10] [RN:R10247]
K10810  
tenI; thiazole tautomerase (transcriptional regulator TenI) [EC:5.3.99.10] [RN:R09977]
K03147  
thiC; phosphomethylpyrimidine synthase [EC:4.1.99.17] [RN:R03472]
K00941  
thiD; phosphomethylpyrimidine kinase [EC:2.7.4.7] [RN:R04509]
K00788  
thiE; thiamine-phosphate pyrophosphorylase [EC:2.5.1.3] [RN:R10712]
K00946  
thiL; thiamine-monophosphate kinase [EC:2.7.4.16] [RN:R00617]
Class
Pathway modules; Metabolism of cofactors and vitamins; Cofactor and vitamin metabolism
Pathway
map00730  Thiamine metabolism
map01240  Biosynthesis of cofactors
map01100  Metabolic pathways
Reaction
Compound
C15810  Sulfur-carrier protein
C15813  Adenylyl-[sulfur-carrier protein]
C15814  Thiocarboxy-[sulfur-carrier protein]
C00037  Glycine
C15809  Iminoglycine
C11437  1-Deoxy-D-xylulose 5-phosphate
C20246  2-[(2R,5Z)-2-Carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate
C20247  2-(2-Carboxy-4-methylthiazol-5-yl)ethyl phosphate
C03373  Aminoimidazole ribotide
C04556  4-Amino-2-methyl-5-(phosphooxymethyl)pyrimidine
C04752  4-Amino-5-hydroxymethyl-2-methylpyrimidine diphosphate
C01081  Thiamin monophosphate
C00068  Thiamin diphosphate
Reference
  Authors
Begley TP, Downs DM, Ealick SE, McLafferty FW, Van Loon AP, Taylor S, Campobasso N, Chiu HJ, Kinsland C, Reddick JJ, Xi J
  Title
Thiamin biosynthesis in prokaryotes.
  Journal
Arch Microbiol 171:293-300 (1999)
DOI:10.1007/s002030050713
Reference
  Authors
Jurgenson CT, Begley TP, Ealick SE
  Title
The structural and biochemical foundations of thiamin biosynthesis.
  Journal
Annu Rev Biochem 78:569-603 (2009)
DOI:10.1146/annurev.biochem.78.072407.102340
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