KEGG   MODULE: M00896
Entry
M00896            Pathway   Module                                 

Name
Thiamine biosynthesis, archaea, AIR (+ NAD+) => TMP/TPP
Definition
K22699
K03147 (K00941 (K00788,K21220),K21219) K00946
Diagram
M00896

Orthology
K22699  
thi4; sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59] [RN:R12026]
K03147  
thiC; phosphomethylpyrimidine synthase [EC:4.1.99.17] [RN:R03472]
K00941  
thiD; phosphomethylpyrimidine kinase [EC:2.7.4.7] [RN:R04509]
thiE,thiN; thiamine-phosphate diphosphorylase [EC:2.5.1.3] [RN:R10712]
K21219  
thiDN; phosphomethylpyrimidine kinase / thiamine-phosphate diphosphorylase [EC:2.7.4.7 2.5.1.3] [RN:R04509 R10712]
K00946  
thiL; thiamine-monophosphate kinase [EC:2.7.4.16] [RN:R00617]
Class
Pathway modules; Metabolism of cofactors and vitamins; Cofactor and vitamin metabolism
Pathway
map00730  Thiamine metabolism
map01240  Biosynthesis of cofactors
map01100  Metabolic pathways
Reaction
Compound
C00037  Glycine
C00003  NAD+
C20784  ADP-5-ethyl-4-methylthiazole-2-carboxylate
C20247  2-(2-Carboxy-4-methylthiazol-5-yl)ethyl phosphate
C03373  Aminoimidazole ribotide
C04556  4-Amino-2-methyl-5-(phosphooxymethyl)pyrimidine
C04752  4-Amino-5-hydroxymethyl-2-methylpyrimidine diphosphate
C01081  Thiamin monophosphate
C00068  Thiamin diphosphate
Reference
  Authors
Hayashi M, Kijima Y, Tazuya-Murayama K, Yamada K
  Title
The Biosynthesis of the Thiazole Moiety of Thiamin in the Archaeon Halobacterium salinarum.
  Journal
J Nutr Sci Vitaminol (Tokyo) 61:270-4 (2015)
DOI:10.3177/jnsv.61.270
Reference
  Authors
Kijima Y, Hayashi M, Yamada K, Tazuya-Murayama K
  Title
The Biosynthesis of the Pyrimidine Moiety of Thiamin in Halobacterium salinarum.
  Journal
J Nutr Sci Vitaminol (Tokyo) 62:130-3 (2016)
DOI:10.3177/jnsv.62.130
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