KEGG   MODULE: M00898
Entry
M00898            Pathway   Module                                 

Name
Thiamine biosynthesis, pyridoxal-5P => TMP/thiamine/TPP
Definition
K03146
K18278 K00877 K14154 -- K00949
Diagram
M00898

Orthology
K03146  
THI4; cysteine-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.60] [RN:R10685]
K18278  
THI5; pyrimidine precursor biosynthesis enzyme [RN:R10686]
K00877  
THI20; phosphomethylpyrimidine kinase [EC:2.7.4.7] [RN:R04509]
K14154  
THI6; thiamine-phosphate diphosphorylase [EC:2.5.1.3] [RN:R10712]
K00949  
THI80; thiamine pyrophosphokinase [EC:2.7.6.2] [RN:R00619]
Class
Pathway modules; Metabolism of cofactors and vitamins; Cofactor and vitamin metabolism
Pathway
map00730  Thiamine metabolism
map01240  Biosynthesis of cofactors
map01100  Metabolic pathways
Reaction
Compound
C00037  Glycine
C00003  NAD+
C20784  ADP-5-ethyl-4-methylthiazole-2-carboxylate
C20247  2-(2-Carboxy-4-methylthiazol-5-yl)ethyl phosphate
C00018  Pyridoxal phosphate
C04556  4-Amino-2-methyl-5-(phosphooxymethyl)pyrimidine
C04752  4-Amino-5-hydroxymethyl-2-methylpyrimidine diphosphate
C01081  Thiamin monophosphate
C00378  Thiamine
C00068  Thiamin diphosphate
Reference
  Authors
Kowalska E, Kozik A
  Title
The genes and enzymes involved in the biosynthesis of thiamin and thiamin diphosphate in yeasts.
  Journal
Cell Mol Biol Lett 13:271-82 (2008)
DOI:10.2478/s11658-007-0055-5
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