KEGG   MODULE: M00915
Entry
M00915            Pathway   Module                                 

Name
Caffeine degradation, caffeine => xanthine
Definition
K21722 K21723 K21724
Diagram
M00915

Orthology
K21722  
ndmA; methylxanthine N1-demethylase [EC:1.14.13.178] [RN:R07957 R07958 R07955 R07956]
K21723  
ndmB; methylxanthine N3-demethylase [EC:1.14.13.179] [RN:R07954 R07939 R07961 R07962]
K21724  
ndmC; 7-methylxanthine demethylase [EC:1.14.13.128] [RN:R07965 R07966]
Class
Pathway modules; Xenobiotics biodegradation; Aromatics degradation
Pathway
map00232  Caffeine metabolism
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
Reaction
Compound
C07481  Caffeine
C13747  1,7-Dimethylxanthine
C16353  7-Methylxanthine
C07480  Theobromine
C00385  Xanthine
Reference
  Authors
Summers RM, Louie TM, Yu CL, Gakhar L, Louie KC, Subramanian M
  Title
Novel, highly specific N-demethylases enable bacteria to live on caffeine and related purine alkaloids.
  Journal
J Bacteriol 194:2041-9 (2012)
DOI:10.1128/JB.06637-11
Reference
  Authors
Yu CL, Louie TM, Summers R, Kale Y, Gopishetty S, Subramanian M
  Title
Two distinct pathways for metabolism of theophylline and caffeine are coexpressed in Pseudomonas putida CBB5.
  Journal
J Bacteriol 191:4624-32 (2009)
DOI:10.1128/JB.00409-09
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