KEGG   NETWORK: N00008
Entry
N00008                      Network                                

Name
RET fusion kinase to RAS-ERK signaling pathway
Definition
RET* -> RAS -> RAF -> MEK -> ERK
  Expanded
5979v1 -> (3265,3845,4893) -> (369,673,5894) -> (5604,5605) -> (5594,5595)
Class
nt06210 ERK signaling
nt06266 Non-small cell lung cancer
nt06274 Thyroid cancer
Type
Variant
Pathway
hsa05216  Thyroid cancer
hsa05223  Non-small cell lung cancer
Disease
H00032  Thyroid cancer
H00014  Non-small cell lung cancer
Gene
5979  RET; ret proto-oncogene
3265  HRAS; HRas proto-oncogene, GTPase
3845  KRAS; KRAS proto-oncogene, GTPase
4893  NRAS; NRAS proto-oncogene, GTPase
369  ARAF; A-Raf proto-oncogene, serine/threonine kinase
673  BRAF; B-Raf proto-oncogene, serine/threonine kinase
5894  RAF1; Raf-1 proto-oncogene, serine/threonine kinase
5604  MAP2K1; mitogen-activated protein kinase kinase 1
5605  MAP2K2; mitogen-activated protein kinase kinase 2
5594  MAPK1; mitogen-activated protein kinase 1
5595  MAPK3; mitogen-activated protein kinase 3
Variant
5979v1 (RET*)  RET fusion
Reference
  Authors
TirrĂ² E, Martorana F, Romano C, Vitale SR, Motta G, Di Gregorio S, Massimino M, Pennisi MS, Stella S, Puma A, Gianì F, Russo M, Manzella L, Vigneri P
  Title
Molecular Alterations in Thyroid Cancer: From Bench to Clinical Practice.
  Journal
Genes (Basel) 10:genes10090709 (2019)
DOI:10.3390/genes10090709
Reference
  Authors
Ferrara R, Auger N, Auclin E, Besse B
  Title
Clinical and Translational Implications of RET Rearrangements in Non-Small Cell Lung Cancer.
  Journal
J Thorac Oncol 13:27-45 (2018)
DOI:10.1016/j.jtho.2017.10.021
Reference
  Authors
Santoro M, Moccia M, Federico G, Carlomagno F
  Title
RET Gene Fusions in Malignancies of the Thyroid and Other Tissues.
  Journal
Genes (Basel) 11:genes11040424 (2020)
DOI:10.3390/genes11040424
Reference
  Authors
Al-Jundi M, Thakur S, Gubbi S, Klubo-Gwiezdzinska J
  Title
Novel Targeted Therapies for Metastatic Thyroid Cancer-A Comprehensive Review.
  Journal
Cancers (Basel) 12:cancers12082104 (2020)
DOI:10.3390/cancers12082104
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