KEGG   NETWORK: N00024
Entry
N00024                      Network                                

Name
Mutation-activated EGFR to PLCG-ERK signaling pathway
Definition
EGFR* -> PLCG -> (Ca2+,DAG) -> PKC -> RAF -> MEK -> ERK -> CCND1
  Expanded
(1956v2,1956v3) -> (5335,5336) -> (C00076,C00165) -> (5578,5579,5582) -> (369,673,5894) -> (5604,5605) -> (5594,5595) -> 595
Class
nt06220 Calcium signaling
nt06266 Non-small cell lung cancer
Type
Variant
Pathway
hsa05223  Non-small cell lung cancer
Disease
H00014  Non-small cell lung cancer
Gene
1956  EGFR; epidermal growth factor receptor
5335  PLCG1; phospholipase C gamma 1
5336  PLCG2; phospholipase C gamma 2
5578  PRKCA; protein kinase C alpha
5579  PRKCB; protein kinase C beta
5582  PRKCG; protein kinase C gamma
369  ARAF; A-Raf proto-oncogene, serine/threonine kinase
673  BRAF; B-Raf proto-oncogene, serine/threonine kinase
5894  RAF1; Raf-1 proto-oncogene, serine/threonine kinase
5604  MAP2K1; mitogen-activated protein kinase kinase 1
5605  MAP2K2; mitogen-activated protein kinase kinase 2
5594  MAPK1; mitogen-activated protein kinase 1
5595  MAPK3; mitogen-activated protein kinase 3
595  CCND1; cyclin D1
Variant
1956v2 (EGFR*)  EGFR mutation in non-small cell lung cancer
1956v3 (EGFR*)  First generation TKI-resistant EGFR mutation
Metabolite
C00076  Calcium cation
C00165  Diacylglycerol
Reference
  Authors
Osada H, Takahashi T.
  Title
Genetic alterations of multiple tumor suppressors and oncogenes in the carcinogenesis and progression of lung cancer.
  Journal
Oncogene 21:7421-34 (2002)
DOI:10.1038/sj.onc.1205802
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