KEGG   NETWORK: N00056
Entry
N00056                      Network                                

Name
Wnt signaling pathway
Definition
WNT -> (FZD+LRP5/6) -> (DVL+FRAT) -| (GSK3B+AXIN+APC) -| CTNNB1 -> TCF/LEF => (MYC,CCND1)
  Expanded
(7471,7472,7482,7473,89780,54361,7474,81029,7475,7476,7477,7478,7479,7483,7484,80326,7480,51384) -> ((8321,2535,7976,8322,7855,8323,8324,8325,8326,11211)+(4041,4040)) -> ((1855,1856,1857)+(10023,23401)) -| (2932+(8312,8313)+324) -| 1499 -> (6932,83439,6934,51176) => (4609,595)
Class
nt06215 WNT signaling
nt06260 Colorectal cancer
nt06261 Gastric cancer
nt06263 Hepatocellular carcinoma
nt06270 Breast cancer
nt06271 Endometrial cancer
nt06274 Thyroid cancer
nt06115 WNT signaling (viruses and bacteria)
nt06164 Kaposi sarcoma-associated herpesvirus (KSHV)
Type
Reference
Pathway
hsa04310  Wnt signaling pathway
Gene
7471  WNT1; Wnt family member 1
7472  WNT2; Wnt family member 2
7482  WNT2B; Wnt family member 2B
7473  WNT3; Wnt family member 3
89780  WNT3A; Wnt family member 3A
54361  WNT4; Wnt family member 4
7474  WNT5A; Wnt family member 5A
81029  WNT5B; Wnt family member 5B
7475  WNT6; Wnt family member 6
7476  WNT7A; Wnt family member 7A
7477  WNT7B; Wnt family member 7B
7478  WNT8A; Wnt family member 8A
7479  WNT8B; Wnt family member 8B
7483  WNT9A; Wnt family member 9A
7484  WNT9B; Wnt family member 9B
80326  WNT10A; Wnt family member 10A
7480  WNT10B; Wnt family member 10B
51384  WNT16; Wnt family member 16
8321  FZD1; frizzled class receptor 1
2535  FZD2; frizzled class receptor 2
7976  FZD3; frizzled class receptor 3
8322  FZD4; frizzled class receptor 4
7855  FZD5; frizzled class receptor 5
8323  FZD6; frizzled class receptor 6
8324  FZD7; frizzled class receptor 7
8325  FZD8; frizzled class receptor 8
8326  FZD9; frizzled class receptor 9
11211  FZD10; frizzled class receptor 10
4041  LRP5; LDL receptor related protein 5
4040  LRP6; LDL receptor related protein 6
1855  DVL1; dishevelled segment polarity protein 1
1856  DVL2; dishevelled segment polarity protein 2
1857  DVL3; dishevelled segment polarity protein 3
10023  FRAT1; FRAT1, WNT signaling pathway regulator
23401  FRAT2; FRAT2, WNT signaling pathway regulator
2932  GSK3B; glycogen synthase kinase 3 beta
8312  AXIN1; axin 1
8313  AXIN2; axin 2
324  APC; APC, WNT signaling pathway regulator
1499  CTNNB1; catenin beta 1
6932  TCF7; transcription factor 7
83439  TCF7L1; transcription factor 7 like 1
6934  TCF7L2; transcription factor 7 like 2
51176  LEF1; lymphoid enhancer binding factor 1
4609  MYC; MYC proto-oncogene, bHLH transcription factor
595  CCND1; cyclin D1
Reference
  Authors
Reya T, Clevers H
  Title
Wnt signalling in stem cells and cancer.
  Journal
Nature 434:843-50 (2005)
DOI:10.1038/nature03319
Reference
  Authors
Duchartre Y, Kim YM, Kahn M
  Title
The Wnt signaling pathway in cancer.
  Journal
Crit Rev Oncol Hematol 99:141-9 (2016)
DOI:10.1016/j.critrevonc.2015.12.005
Reference
  Authors
Luo J, Chen J, Deng ZL, Luo X, Song WX, Sharff KA, Tang N, Haydon RC, Luu HH, He TC
  Title
Wnt signaling and human diseases: what are the therapeutic implications?
  Journal
Lab Invest 87:97-103 (2007)
DOI:10.1038/labinvest.3700509
Reference
  Authors
Yang Y.
  Title
Wnts and wing: Wnt signaling in vertebrate limb development and musculoskeletal morphogenesis.
  Journal
Birth Defects Res Part C Embryo Today 69:305-17 (2003)
DOI:10.1002/bdrc.10026
Reference
  Authors
Baron R, Kneissel M
  Title
WNT signaling in bone homeostasis and disease: from human mutations to treatments.
  Journal
Nat Med 19:179-92 (2013)
DOI:10.1038/nm.3074
Reference
  Authors
Staal FJ, Clevers HC
  Title
WNT signalling and haematopoiesis: a WNT-WNT situation.
  Journal
Nat Rev Immunol 5:21-30 (2005)
DOI:10.1038/nri1529
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