KEGG   NETWORK: N00075
Entry
N00075                      Network                                

Name
Mutation-inactivated RB1 to cell cycle G1/S
Definition
RB1* // E2F
  Expanded
5925v2 // (1869,1870,1871)
Class
nt06230 Cell cycle G1/S
nt06265 Bladder cancer
nt06267 Small cell lung cancer
Type
Variant
Pathway
hsa05219  Bladder cancer
hsa05222  Small cell lung cancer
Disease
H00022  Bladder cancer
H00013  Small cell lung cancer
Gene
5925  RB1; RB transcriptional corepressor 1
1869  E2F1; E2F transcription factor 1
1870  E2F2; E2F transcription factor 2
1871  E2F3; E2F transcription factor 3
Variant
5925v2 (RB1*)  RB1 mutation
Reference
  Authors
Mitra AP, Datar RH, Cote RJ.
  Title
Molecular pathways in invasive bladder cancer: new insights into mechanisms, progression, and target identification.
  Journal
J Clin Oncol 24:5552-64 (2006)
DOI:10.1200/JCO.2006.08.2073
Reference
  Authors
Osada H, Takahashi T.
  Title
Genetic alterations of multiple tumor suppressors and oncogenes in the carcinogenesis and progression of lung cancer.
  Journal
Oncogene 21:7421-34 (2002)
DOI:10.1038/sj.onc.1205802
LinkDB

DBGET integrated database retrieval system