KEGG   NETWORK: N00092
Entry
N00092                      Network                                

Name
Amplified MYC to p27-cell cycle G1/S
Definition
(MYC*+MAX) => CKS1B -> (SCF+SKP2) -| CDKN1B -| (CCNE+CDK2) -> RB1 // E2F
  Expanded
(4609v1+4149) => 1163 -> (6500+8454+9978+6502) -| 1027 -| ((898,9134)+1017) -> 5925 // (1869,1870,1871)
Class
nt06230 Cell cycle G1/S
nt06267 Small cell lung cancer
Type
Variant
Pathway
hsa05222  Small cell lung cancer
Disease
H00013  Small cell lung cancer
Gene
4609  MYC; MYC proto-oncogene, bHLH transcription factor
4149  MAX; MYC associated factor X
1163  CKS1B; CDC28 protein kinase regulatory subunit 1B
6500  SKP1; S-phase kinase associated protein 1
8454  CUL1; cullin 1
9978  RBX1; ring-box 1
6502  SKP2; S-phase kinase associated protein 2
1027  CDKN1B; cyclin dependent kinase inhibitor 1B
898  CCNE1; cyclin E1
9134  CCNE2; cyclin E2
1017  CDK2; cyclin dependent kinase 2
5925  RB1; RB transcriptional corepressor 1
1869  E2F1; E2F transcription factor 1
1870  E2F2; E2F transcription factor 2
1871  E2F3; E2F transcription factor 3
Variant
4609v1 (MYC*)  MYC amplification
Reference
  Authors
Osada H, Takahashi T.
  Title
Genetic alterations of multiple tumor suppressors and oncogenes in the carcinogenesis and progression of lung cancer.
  Journal
Oncogene 21:7421-34 (2002)
DOI:10.1038/sj.onc.1205802
Reference
  Authors
Spruck C, Strohmaier H, Watson M, Smith AP, Ryan A, Krek TW, Reed SI.
  Title
A CDK-independent function of mammalian Cks1: targeting of SCF(Skp2) to the CDK inhibitor p27Kip1.
  Journal
Mol Cell 7:639-50 (2001)
DOI:10.1016/S1097-2765(01)00210-6
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