KEGG   NETWORK: N00286
Entry
N00286                      Network                                

Name
Nuclear-initiated estrogen signaling pathway
Definition
E2 -- ((ESR1/2)+(NCOA1/2/3)) => (BCL2,EBAG9,KRT19,CTSD,TFF1,PGR)
  Expanded
C00951 -- ((2099,2100)+(8648,10499,8202)) => (596,9166,3880,1509,7031,5241)
Class
nt06227 Nuclear receptor signaling
nt06270 Breast cancer
nt06323 KISS1-GnRH-LH/FSH-E2 signaling
Type
Reference
Pathway
hsa04915  Estrogen signaling pathway
Gene
2099  ESR1; estrogen receptor 1
2100  ESR2; estrogen receptor 2
8648  NCOA1; nuclear receptor coactivator 1
10499  NCOA2; nuclear receptor coactivator 2
8202  NCOA3; nuclear receptor coactivator 3
596  BCL2; BCL2, apoptosis regulator
9166  EBAG9; estrogen receptor binding site associated, antigen, 9
3880  KRT19; keratin 19
1509  CTSD; cathepsin D
7031  TFF1; trefoil factor 1
5241  PGR; progesterone receptor
Metabolite
C00951  Estradiol-17beta
Reference
  Authors
Ascenzi P, Bocedi A, Marino M
  Title
Structure-function relationship of estrogen receptor alpha and beta: impact on human health.
  Journal
Mol Aspects Med 27:299-402 (2006)
DOI:10.1016/j.mam.2006.07.001
Reference
  Authors
Egeland NG, Lunde S, Jonsdottir K, Lende TH, Cronin-Fenton D, Gilje B, Janssen EA, Soiland H
  Title
The Role of MicroRNAs as Predictors of Response to Tamoxifen Treatment in Breast Cancer Patients.
  Journal
Int J Mol Sci 16:24243-75 (2015)
DOI:10.3390/ijms161024243
Reference
  Authors
McDonnell DP, Norris JD
  Title
Connections and regulation of the human estrogen receptor.
  Journal
Science 296:1642-4 (2002)
DOI:10.1126/science.1071884
Reference
  Authors
Welboren WJ, Sweep FC, Span PN, Stunnenberg HG
  Title
Genomic actions of estrogen receptor alpha: what are the targets and how are they regulated?
  Journal
Endocr Relat Cancer 16:1073-89 (2009)
DOI:10.1677/ERC-09-0086
Reference
  Authors
Carroll JS, Meyer CA, Song J, Li W, Geistlinger TR, Eeckhoute J, Brodsky AS, Keeton EK, Fertuck KC, Hall GF, Wang Q, Bekiranov S, Sementchenko V, Fox EA, Silver PA, Gingeras TR, Liu XS, Brown M
  Title
Genome-wide analysis of estrogen receptor binding sites.
  Journal
Nat Genet 38:1289-97 (2006)
DOI:10.1038/ng1901
Reference
  Authors
O'Lone R, Frith MC, Karlsson EK, Hansen U
  Title
Genomic targets of nuclear estrogen receptors.
  Journal
Mol Endocrinol 18:1859-75 (2004)
DOI:10.1210/me.2003-0044
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