KEGG   NETWORK: N00355
Entry
N00355                      Network                                

Name
PP2A-AKT signaling pathway
Definition
PP2A -| AKT
  Expanded
((5515,5516)+(5518,5519)+(5520,5521,5522,55844,5523,28227,55012,5525,5526,5527,5528,5529)) -| (207,208,10000)
Class
nt06114 PI3K signaling (viruses)
nt06166 Human papillomavirus (HPV)
Type
Reference
Pathway
hsa04151  PI3K-Akt signaling pathway
Gene
5515  PPP2CA; protein phosphatase 2 catalytic subunit alpha
5516  PPP2CB; protein phosphatase 2 catalytic subunit beta
5518  PPP2R1A; protein phosphatase 2 scaffold subunit Aalpha
5519  PPP2R1B; protein phosphatase 2 scaffold subunit Abeta
5520  PPP2R2A; protein phosphatase 2 regulatory subunit Balpha
5521  PPP2R2B; protein phosphatase 2 regulatory subunit Bbeta
5522  PPP2R2C; protein phosphatase 2 regulatory subunit Bgamma
55844  PPP2R2D; protein phosphatase 2 regulatory subunit Bdelta
5523  PPP2R3A; protein phosphatase 2 regulatory subunit B''alpha
28227  PPP2R3B; protein phosphatase 2 regulatory subunit B''beta
55012  PPP2R3C; protein phosphatase 2 regulatory subunit B''gamma
5525  PPP2R5A; protein phosphatase 2 regulatory subunit B'alpha
5526  PPP2R5B; protein phosphatase 2 regulatory subunit B'beta
5527  PPP2R5C; protein phosphatase 2 regulatory subunit B'gamma
5528  PPP2R5D; protein phosphatase 2 regulatory subunit B'delta
5529  PPP2R5E; protein phosphatase 2 regulatory subunit B'epsilon
207  AKT1; AKT serine/threonine kinase 1
208  AKT2; AKT serine/threonine kinase 2
10000  AKT3; AKT serine/threonine kinase 3
Reference
  Authors
Li L, Ren CH, Tahir SA, Ren C, Thompson TC
  Title
Caveolin-1 maintains activated Akt in prostate cancer cells through scaffolding domain binding site interactions with and inhibition of serine/threonine protein  phosphatases PP1 and PP2A.
  Journal
Mol Cell Biol 23:9389-404 (2003)
DOI:10.1128/MCB.23.24.9389-9404.2003
Reference
  Authors
Ciccone M, Calin GA, Perrotti D
  Title
From the Biology of PP2A to the PADs for Therapy of Hematologic Malignancies.
  Journal
Front Oncol 5:21 (2015)
DOI:10.3389/fonc.2015.00021
Reference
  Authors
Seshacharyulu P, Pandey P, Datta K, Batra SK
  Title
Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancer.
  Journal
Cancer Lett 335:9-18 (2013)
DOI:10.1016/j.canlet.2013.02.036
Reference
  Authors
Sangodkar J, Farrington CC, McClinch K, Galsky MD, Kastrinsky DB, Narla G
  Title
All roads lead to PP2A: exploiting the therapeutic potential of this phosphatase.
  Journal
FEBS J 283:1004-24 (2016)
DOI:10.1111/febs.13573
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