KEGG   NETWORK: N00388
Entry
N00388                      Network                                

Name
HCMV UL38 to MTOR signaling pathway
Definition
UL38 -| (TSC1+TSC2) -| RHEB -> MTOR -> S6K
  Expanded
K22776 -| (7248+7249) -| 6009 -> 2475 -> (6198,6199)
Class
nt06114 PI3K signaling (viruses)
nt06167 Human cytomegalovirus (HCMV)
Type
Pathogen
Pathway
hsa05163  Human cytomegalovirus infection
Disease
H00368  Cytomegalovirus infection
Gene
7248  TSC1; TSC complex subunit 1
7249  TSC2; TSC complex subunit 2
6009  RHEB; Ras homolog, mTORC1 binding
2475  MTOR; mechanistic target of rapamycin kinase
6198  RPS6KB1; ribosomal protein S6 kinase B1
6199  RPS6KB2; ribosomal protein S6 kinase B2
Perturbant
K22776 (UL38)  UL38; Cytomegalovirus apoptosis inhibitor UL38
Reference
  Authors
Moorman NJ, Cristea IM, Terhune SS, Rout MP, Chait BT, Shenk T
  Title
Human cytomegalovirus protein UL38 inhibits host cell stress responses by antagonizing the tuberous sclerosis protein complex.
  Journal
Cell Host Microbe 3:253-62 (2008)
DOI:10.1016/j.chom.2008.03.002
Reference
  Authors
Shenk T, Alwine JC
  Title
Human Cytomegalovirus: Coordinating Cellular Stress, Signaling, and Metabolic Pathways.
  Journal
Annu Rev Virol 1:355-74 (2014)
DOI:10.1146/annurev-virology-031413-085425
Reference
  Authors
Roy S, Arav-Boger R
  Title
New cell-signaling pathways for controlling cytomegalovirus replication.
  Journal
Am J Transplant 14:1249-58 (2014)
DOI:10.1111/ajt.12725
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