KEGG   NETWORK: N00401
Entry
N00401                      Network                                

Name
CXCR4-GNAQ-PLCB/G-calcineurin signaling pathway
Definition
CXCL12 -> CXCR4 -> GNAQ -> (PLCB,PLCG) -> IP3 -> Ca2+ -> CALM -- CN -> NFAT
  Expanded
6387 -> 7852 -> 2776 -> (23236,5330,5331,5332,5335,5336) -> C01245 -> C00076 -> (801,805,808) -- (5530,5532,5533,5534,5535) -> (4772,4773,4775,4776)
Class
nt06124 Chemokine signaling (viruses)
nt06150 Cytokine-cytokine receptor interaction (viruses)
nt06161 Human immunodeficiency virus type 1 (HIV-1)
nt06167 Human cytomegalovirus (HCMV)
Type
Reference
Pathway
hsa04062  Chemokine signaling pathway
hsa04020  Calcium signaling pathway
Gene
6387  CXCL12; C-X-C motif chemokine ligand 12
7852  CXCR4; C-X-C motif chemokine receptor 4
2776  GNAQ; G protein subunit alpha q
23236  PLCB1; phospholipase C beta 1
5330  PLCB2; phospholipase C beta 2
5331  PLCB3; phospholipase C beta 3
5332  PLCB4; phospholipase C beta 4
5335  PLCG1; phospholipase C gamma 1
5336  PLCG2; phospholipase C gamma 2
801  CALM1; calmodulin 1
805  CALM2; calmodulin 2
808  CALM3; calmodulin 3
5530  PPP3CA; protein phosphatase 3 catalytic subunit alpha
5532  PPP3CB; protein phosphatase 3 catalytic subunit beta
5533  PPP3CC; protein phosphatase 3 catalytic subunit gamma
5534  PPP3R1; protein phosphatase 3 regulatory subunit B, alpha
5535  PPP3R2; protein phosphatase 3 regulatory subunit B, beta
4772  NFATC1; nuclear factor of activated T cells 1
4773  NFATC2; nuclear factor of activated T cells 2
4775  NFATC3; nuclear factor of activated T cells 3
4776  NFATC4; nuclear factor of activated T cells 4
Metabolite
C01245  D-myo-Inositol 1,4,5-trisphosphate
C00076  Calcium cation
Reference
  Authors
Wu Y, Yoder A
  Title
Chemokine coreceptor signaling in HIV-1 infection and pathogenesis.
  Journal
PLoS Pathog 5:e1000520 (2009)
DOI:10.1371/journal.ppat.1000520
Reference
  Authors
Knopf A, Fritsche MK, Li Y
  Title
CXCR4: A New Player in an Old Scene?
  Journal
ORL J Otorhinolaryngol Relat Spec 79:34-42 (2017)
DOI:10.1159/000455706
Reference
  Authors
Scala S
  Title
Molecular Pathways: Targeting the CXCR4-CXCL12 Axis--Untapped Potential in the Tumor Microenvironment.
  Journal
Clin Cancer Res 21:4278-85 (2015)
DOI:10.1158/1078-0432.CCR-14-0914
Reference
  Authors
Barbieri F, Bajetto A, Florio T
  Title
Role of chemokine network in the development and progression of ovarian cancer: a potential novel pharmacological target.
  Journal
J Oncol 2010:426956 (2010)
DOI:10.1155/2010/426956
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