KEGG   NETWORK: N00404
Entry
N00404                      Network                                

Name
HCMV US28 to GNAI-AC-PKA signaling pathway
Definition
US28 -> (GNAI,GNAO) -| ADCY -> cAMP -> PKA
  Expanded
K22781 -> (2770,2771,2773,2775) -| (107,108,109,196883,111,112,113,114,115) -> C00575 -> (5566+5567+5568)
Class
nt06124 Chemokine signaling (viruses)
nt06150 Cytokine-cytokine receptor interaction (viruses)
nt06167 Human cytomegalovirus (HCMV)
Type
Pathogen
Pathway
hsa05163  Human cytomegalovirus infection
Disease
H00368  Cytomegalovirus infection
Gene
2770  GNAI1; G protein subunit alpha i1
2771  GNAI2; G protein subunit alpha i2
2773  GNAI3; G protein subunit alpha i3
2775  GNAO1; G protein subunit alpha o1
107  ADCY1; adenylate cyclase 1
108  ADCY2; adenylate cyclase 2
109  ADCY3; adenylate cyclase 3
196883  ADCY4; adenylate cyclase 4
111  ADCY5; adenylate cyclase 5
112  ADCY6; adenylate cyclase 6
113  ADCY7; adenylate cyclase 7
114  ADCY8; adenylate cyclase 8
115  ADCY9; adenylate cyclase 9
5566  PRKACA; protein kinase cAMP-activated catalytic subunit alpha
5567  PRKACB; protein kinase cAMP-activated catalytic subunit beta
5568  PRKACG; protein kinase cAMP-activated catalytic subunit gamma
Perturbant
K22781 (US28)  US28; HCMV envelope protein US28
Metabolite
C00575  3',5'-Cyclic AMP
Reference
  Authors
Couty JP, Gershengorn MC
  Title
G-protein-coupled receptors encoded by human herpesviruses.
  Journal
Trends Pharmacol Sci 26:405-11 (2005)
DOI:10.1016/j.tips.2005.06.004
Reference
  Authors
Lee S, Chung YH, Lee C
  Title
US28, a Virally-Encoded GPCR as an Antiviral Target for Human Cytomegalovirus Infection.
  Journal
Biomol Ther (Seoul) 25:69-79 (2017)
DOI:10.4062/biomolther.2016.208
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